Nonhematologic toxicity during induction therapy classified by risk group
| Adverse event . | Good risk (n = 79) . | Poor risk (n = 54) . | ||||||
|---|---|---|---|---|---|---|---|---|
| Grade . | Grade . | |||||||
| ≤2 | 3 | 4 | 5 | ≤2 | 3 | 4 | 5 | |
| Cardiac arrhythmia | 78 | 0 | 1 | 0 | 54 | 0 | 0 | 0 |
| Cardiac general | 76 | 1 | 1 | 1 | 50 | 3 | 1 | 0 |
| Cardiovascular pain | 77 | 2 | 0 | 0 | 54 | 0 | 0 | 0 |
| Conduction abnormality | 79 | 0 | 0 | 0 | 53 | 1 | 0 | 0 |
| Death | 76 | 0 | 0 | 3 | 52 | 0 | 0 | 2 |
| Dermatologic/skin | 78 | 1 | 0 | 0 | 54 | 0 | 0 | 0 |
| Eye infection, Gr. 3-4 ANC | 78 | 1 | 0 | 0 | 54 | 0 | 0 | 0 |
| Flu-like symptoms | 71 | 8 | 0 | 0 | 44 | 9 | 1 | 0 |
| GI hemorrhage | 78 | 1 | 0 | 0 | 53 | 1 | 0 | 0 |
| GI infection, Gr. 3-4 ANC | 75 | 4 | 0 | 0 | 53 | 1 | 0 | 0 |
| GU infection, Gr. 3-4 ANC | 77 | 2 | 0 | 0 | 53 | 0 | 1 | 0 |
| Gastrointestinal | 72 | 6 | 1 | 0 | 51 | 3 | 0 | 0 |
| Hematologic | 15 | 4 | 60 | 0 | 12 | 4 | 38 | 0 |
| Hemorrhage | 77 | 2 | 0 | 0 | 53 | 1 | 0 | 0 |
| Hepatobiliary/pancreas | 78 | 1 | 0 | 0 | 54 | 0 | 0 | 0 |
| Infection | 48 | 28 | 3 | 0 | 35 | 15 | 3 | 1 |
| Infection, Gr. 0-2 ANC | 78 | 1 | 0 | 0 | 53 | 0 | 1 | 0 |
| Infection, Gr. 3-4 ANC | 67 | 12 | 0 | 0 | 49 | 2 | 2 | 1 |
| Infection, Unk ANC | 79 | 0 | 0 | 0 | 53 | 0 | 0 | 1 |
| Lung | 73 | 5 | 1 | 0 | 49 | 3 | 1 | 1 |
| Lung infection, Gr. 3-4 ANC | 73 | 4 | 1 | 1 | 50 | 3 | 0 | 1 |
| Lung infection, Unk ANC | 79 | 0 | 0 | 0 | 53 | 0 | 0 | 1 |
| Lymphatics | 78 | 1 | 0 | 0 | 54 | 0 | 0 | 0 |
| Metabolic/laboratory | 62 | 15 | 2 | 0 | 45 | 8 | 1 | 0 |
| Mood alteration | 79 | 0 | 0 | 0 | 52 | 2 | 0 | 0 |
| Mucositis, functional | 78 | 1 | 0 | 0 | 54 | 0 | 0 | 0 |
| Muscle weakness | 76 | 2 | 1 | 0 | 53 | 0 | 1 | 0 |
| Neurologic | 78 | 1 | 0 | 0 | 54 | 0 | 0 | 0 |
| Skin infection, Gr. 0-2 ANC | 78 | 1 | 0 | 0 | 54 | 0 | 0 | 0 |
| Skin infection, Gr. 3-4 ANC | 74 | 5 | 0 | 0 | 53 | 1 | 0 | 0 |
| Skin infection, Unk ANC | 78 | 1 | 0 | 0 | 54 | 0 | 0 | 0 |
| Supraventricular arrhythmia | 78 | 1 | 0 | 0 | 52 | 0 | 2 | 0 |
| Syndromes | 79 | 0 | 0 | 0 | 53 | 1 | 0 | 0 |
| Vascular | 77 | 0 | 2 | 0 | 54 | 0 | 0 | 0 |
| Maximum grade any adverse event | ||||||||
| No. | 5 | 12 | 58 | 4 | 4 | 10 | 35 | 5 |
| Adverse event . | Good risk (n = 79) . | Poor risk (n = 54) . | ||||||
|---|---|---|---|---|---|---|---|---|
| Grade . | Grade . | |||||||
| ≤2 | 3 | 4 | 5 | ≤2 | 3 | 4 | 5 | |
| Cardiac arrhythmia | 78 | 0 | 1 | 0 | 54 | 0 | 0 | 0 |
| Cardiac general | 76 | 1 | 1 | 1 | 50 | 3 | 1 | 0 |
| Cardiovascular pain | 77 | 2 | 0 | 0 | 54 | 0 | 0 | 0 |
| Conduction abnormality | 79 | 0 | 0 | 0 | 53 | 1 | 0 | 0 |
| Death | 76 | 0 | 0 | 3 | 52 | 0 | 0 | 2 |
| Dermatologic/skin | 78 | 1 | 0 | 0 | 54 | 0 | 0 | 0 |
| Eye infection, Gr. 3-4 ANC | 78 | 1 | 0 | 0 | 54 | 0 | 0 | 0 |
| Flu-like symptoms | 71 | 8 | 0 | 0 | 44 | 9 | 1 | 0 |
| GI hemorrhage | 78 | 1 | 0 | 0 | 53 | 1 | 0 | 0 |
| GI infection, Gr. 3-4 ANC | 75 | 4 | 0 | 0 | 53 | 1 | 0 | 0 |
| GU infection, Gr. 3-4 ANC | 77 | 2 | 0 | 0 | 53 | 0 | 1 | 0 |
| Gastrointestinal | 72 | 6 | 1 | 0 | 51 | 3 | 0 | 0 |
| Hematologic | 15 | 4 | 60 | 0 | 12 | 4 | 38 | 0 |
| Hemorrhage | 77 | 2 | 0 | 0 | 53 | 1 | 0 | 0 |
| Hepatobiliary/pancreas | 78 | 1 | 0 | 0 | 54 | 0 | 0 | 0 |
| Infection | 48 | 28 | 3 | 0 | 35 | 15 | 3 | 1 |
| Infection, Gr. 0-2 ANC | 78 | 1 | 0 | 0 | 53 | 0 | 1 | 0 |
| Infection, Gr. 3-4 ANC | 67 | 12 | 0 | 0 | 49 | 2 | 2 | 1 |
| Infection, Unk ANC | 79 | 0 | 0 | 0 | 53 | 0 | 0 | 1 |
| Lung | 73 | 5 | 1 | 0 | 49 | 3 | 1 | 1 |
| Lung infection, Gr. 3-4 ANC | 73 | 4 | 1 | 1 | 50 | 3 | 0 | 1 |
| Lung infection, Unk ANC | 79 | 0 | 0 | 0 | 53 | 0 | 0 | 1 |
| Lymphatics | 78 | 1 | 0 | 0 | 54 | 0 | 0 | 0 |
| Metabolic/laboratory | 62 | 15 | 2 | 0 | 45 | 8 | 1 | 0 |
| Mood alteration | 79 | 0 | 0 | 0 | 52 | 2 | 0 | 0 |
| Mucositis, functional | 78 | 1 | 0 | 0 | 54 | 0 | 0 | 0 |
| Muscle weakness | 76 | 2 | 1 | 0 | 53 | 0 | 1 | 0 |
| Neurologic | 78 | 1 | 0 | 0 | 54 | 0 | 0 | 0 |
| Skin infection, Gr. 0-2 ANC | 78 | 1 | 0 | 0 | 54 | 0 | 0 | 0 |
| Skin infection, Gr. 3-4 ANC | 74 | 5 | 0 | 0 | 53 | 1 | 0 | 0 |
| Skin infection, Unk ANC | 78 | 1 | 0 | 0 | 54 | 0 | 0 | 0 |
| Supraventricular arrhythmia | 78 | 1 | 0 | 0 | 52 | 0 | 2 | 0 |
| Syndromes | 79 | 0 | 0 | 0 | 53 | 1 | 0 | 0 |
| Vascular | 77 | 0 | 2 | 0 | 54 | 0 | 0 | 0 |
| Maximum grade any adverse event | ||||||||
| No. | 5 | 12 | 58 | 4 | 4 | 10 | 35 | 5 |
Adverse events unlikely or not related to treatment have been excluded, and adverse events with no entries for grades 3 to 5 have been suppressed.
GI, gastrointestinal; Gr., grade; GU, genitourinary; Unk, unknown.