MDS cytogenetic scoring system: prognostic relevance of cytogenetic abnormalities in 7012 patients included in the International Working Group for Prognosis in MDS (IWG-PM) database
| Prognostic cytogenetic subgroup . | Cytogenetic abnormalities . | Proportion of MDS patients, % . | Median overall survival, years . | Median time to 25% AML evolution, years . |
|---|---|---|---|---|
| Very good | −Y, del(11q) | 4 | 5.4 | Not reached |
| Good | Normal karyotype, del(5q), del(12p), del(20q), double abnormality including del(5q) | 72 | 4.8 | 9.4 |
| Intermediate | del(7q), +8, +19, i(17q), any other single or double independent clones | 13 | 2.7 | 2.5 |
| High | −7, inv(3)/t(3q)/del(3q), double including −7/del(7q), complex: 3 abnormalities | 4 | 1.5 | 1.7 |
| Very high | Complex karyotype: >3 abnormalities | 7 | 0.7 | 0.7 |
| Prognostic cytogenetic subgroup . | Cytogenetic abnormalities . | Proportion of MDS patients, % . | Median overall survival, years . | Median time to 25% AML evolution, years . |
|---|---|---|---|---|
| Very good | −Y, del(11q) | 4 | 5.4 | Not reached |
| Good | Normal karyotype, del(5q), del(12p), del(20q), double abnormality including del(5q) | 72 | 4.8 | 9.4 |
| Intermediate | del(7q), +8, +19, i(17q), any other single or double independent clones | 13 | 2.7 | 2.5 |
| High | −7, inv(3)/t(3q)/del(3q), double including −7/del(7q), complex: 3 abnormalities | 4 | 1.5 | 1.7 |
| Very high | Complex karyotype: >3 abnormalities | 7 | 0.7 | 0.7 |
Reproduced from Greenberg et al.26