Exposure to UVR and risk of HL by histologic subtype and by tumor EBV status
UVR exposure . | Histology . | Tumor EBV status . | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nodular sclerosis . | Mixed cellularity . | Positive . | Negative . | |||||||||||||
Cases (n = 928) . | Controls (n = 6381) . | OR . | 95% CI . | Cases (n = 242) . | Controls (n = 6381) . | OR . | 95% CI . | Cases (n = 208) . | Controls (n = 5964) . | OR . | 95% CI . | Cases (n = 526) . | Controls (n = 5964) . | OR . | 95% CI . | |
Overall* | ||||||||||||||||
Low | 182 | 1323 | 1.00 | 55 | 1323 | 1.00 | 56 | 1323 | 1.00 | 121 | 1323 | 1.00 | ||||
Low-mid | 218 | 1432 | 1.00 | 0.78-1.28 | 49 | 1432 | 0.77 | 0.50-1.18 | 55 | 1432 | 0.80 | 0.51-1.26 | 132 | 1432 | 0.96 | 0.70-1.32 |
Mid-high | 214 | 1397 | 0.97 | 0.75-1.26 | 53 | 1397 | 0.83 | 0.54-1.27 | 46 | 1397 | 0.60† | 0.36-0.98 | 135 | 1397 | 0.93 | 0.67-1.28 |
High | 202 | 1683 | 0.88 | 0.68-1.14 | 65 | 1683 | 0.85 | 0.56-1.29 | 51 | 1683 | 0.56† | 0.35-0.91 | 138 | 1683 | 0.86 | 0.63-1.19 |
Ptrend‡ | 0.14 | 0.52 | 0.03 | 0,02 | ||||||||||||
P§ | 0.40 | 0.28 | 0.09 | 0.36 | ||||||||||||
Childhood | ||||||||||||||||
Low | 186 | 1373 | 1.00 | 42 | 1373 | 1.00 | 50 | 1373 | 1.00 | 109 | 1373 | 1.00 | ||||
Low-mid | 212 | 1543 | 0.73† | 0.59-0.90 | 50 | 1543 | 0.91 | 0.63-1.31 | 52 | 1543 | 0.60† | 0.37-0.97 | 143 | 1543 | 0.75 | 0.54-1.03 |
Mid-high | 149 | 1090 | 0.84 | 0.75-1.07 | 39 | 1090 | 1.03 | 0.60-1.77 | 30 | 1090 | 0.62 | 0.35-1.07 | 77 | 1090 | 0.70 | 0.48-1.02 |
High | 166 | 1608 | 0.79 | 0.63-1.00 | 52 | 1608 | 0.90 | 0.61-1.31 | 49 | 1608 | 0.36 | 0.10-1.34 | 129 | 1608 | 0.85 | 0.60-1.21 |
Ptrend | 0.28 | 0.59 | 0.06 | 0.55 | ||||||||||||
P§ | 0.20 | 0.16 | 0.14 | 0.11 | ||||||||||||
Adult | ||||||||||||||||
Low | 231 | 1453 | 1.00 | 57 | 1453 | 1.00 | 58 | 1247 | 1.00 | 107 | 1247 | 1.00 | ||||
Low-mid | 172 | 1492 | 0.77 | 0.55-1.08 | 47 | 1492 | 0.77 | 0.49-1.20 | 30 | 1420 | 0.43† | 0.26-0.73 | 93 | 1420 | 0.69† | 0.48-0.98 |
Mid-high | 191 | 1425 | 0.87 | 0.68-1.12 | 38 | 1425 | 0.63 | 0.40-1.01 | 33 | 1354 | 0.37† | 0.21-0.65 | 101 | 1354 | 0.90 | 0.63-1.27 |
High | 168 | 1633 | 0.75† | 0.58-0.98 | 68 | 1633 | 1.03 | 0.68-1.56 | 45 | 1565 | 0.59† | 0.36-0.96 | 104 | 1565 | 0.92 | 0.65-1.29 |
Ptrend | 0.11 | 0.94 | 0.49 | 0.99 | ||||||||||||
P§ | 0.34 | 0.44 | 0.10 | 0.53 | ||||||||||||
History of sunburn | ||||||||||||||||
No | 242 | 1548 | 1.00 | 65 | 1548 | 1.00 | 61 | 1548 | 1.00 | 132 | 1548 | 1.00 | ||||
Yes | 488 | 3681 | 0.67† | 0.53-0.84 | 127 | 3681 | 0.92 | 0.59-1.43 | 132 | 3681 | 0.81 | 0.51-1.29 | 335 | 3681 | 0.65† | 0.48-0.89 |
P§ | 0.56 | 0.98 | 0.27 | 0.44 | ||||||||||||
History of sunlamp use | ||||||||||||||||
No | 361 | 3428 | 1.00 | 120 | 3428 | 1.00 | 97 | 3428 | 1.00 | 187 | 3428 | 1.00 | ||||
Yes | 455 | 2501 | 0.85 | 0.70-1.03 | 103 | 2501 | 0.80 | 0.58-1.10 | 111 | 2501 | 0.69 | 0.47-1.02 | 338 | 2501 | 0.88 | 0.68-1.13 |
P§ | 0.32 | 0.72 | 0.10 | 0.98 |
UVR exposure . | Histology . | Tumor EBV status . | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nodular sclerosis . | Mixed cellularity . | Positive . | Negative . | |||||||||||||
Cases (n = 928) . | Controls (n = 6381) . | OR . | 95% CI . | Cases (n = 242) . | Controls (n = 6381) . | OR . | 95% CI . | Cases (n = 208) . | Controls (n = 5964) . | OR . | 95% CI . | Cases (n = 526) . | Controls (n = 5964) . | OR . | 95% CI . | |
Overall* | ||||||||||||||||
Low | 182 | 1323 | 1.00 | 55 | 1323 | 1.00 | 56 | 1323 | 1.00 | 121 | 1323 | 1.00 | ||||
Low-mid | 218 | 1432 | 1.00 | 0.78-1.28 | 49 | 1432 | 0.77 | 0.50-1.18 | 55 | 1432 | 0.80 | 0.51-1.26 | 132 | 1432 | 0.96 | 0.70-1.32 |
Mid-high | 214 | 1397 | 0.97 | 0.75-1.26 | 53 | 1397 | 0.83 | 0.54-1.27 | 46 | 1397 | 0.60† | 0.36-0.98 | 135 | 1397 | 0.93 | 0.67-1.28 |
High | 202 | 1683 | 0.88 | 0.68-1.14 | 65 | 1683 | 0.85 | 0.56-1.29 | 51 | 1683 | 0.56† | 0.35-0.91 | 138 | 1683 | 0.86 | 0.63-1.19 |
Ptrend‡ | 0.14 | 0.52 | 0.03 | 0,02 | ||||||||||||
P§ | 0.40 | 0.28 | 0.09 | 0.36 | ||||||||||||
Childhood | ||||||||||||||||
Low | 186 | 1373 | 1.00 | 42 | 1373 | 1.00 | 50 | 1373 | 1.00 | 109 | 1373 | 1.00 | ||||
Low-mid | 212 | 1543 | 0.73† | 0.59-0.90 | 50 | 1543 | 0.91 | 0.63-1.31 | 52 | 1543 | 0.60† | 0.37-0.97 | 143 | 1543 | 0.75 | 0.54-1.03 |
Mid-high | 149 | 1090 | 0.84 | 0.75-1.07 | 39 | 1090 | 1.03 | 0.60-1.77 | 30 | 1090 | 0.62 | 0.35-1.07 | 77 | 1090 | 0.70 | 0.48-1.02 |
High | 166 | 1608 | 0.79 | 0.63-1.00 | 52 | 1608 | 0.90 | 0.61-1.31 | 49 | 1608 | 0.36 | 0.10-1.34 | 129 | 1608 | 0.85 | 0.60-1.21 |
Ptrend | 0.28 | 0.59 | 0.06 | 0.55 | ||||||||||||
P§ | 0.20 | 0.16 | 0.14 | 0.11 | ||||||||||||
Adult | ||||||||||||||||
Low | 231 | 1453 | 1.00 | 57 | 1453 | 1.00 | 58 | 1247 | 1.00 | 107 | 1247 | 1.00 | ||||
Low-mid | 172 | 1492 | 0.77 | 0.55-1.08 | 47 | 1492 | 0.77 | 0.49-1.20 | 30 | 1420 | 0.43† | 0.26-0.73 | 93 | 1420 | 0.69† | 0.48-0.98 |
Mid-high | 191 | 1425 | 0.87 | 0.68-1.12 | 38 | 1425 | 0.63 | 0.40-1.01 | 33 | 1354 | 0.37† | 0.21-0.65 | 101 | 1354 | 0.90 | 0.63-1.27 |
High | 168 | 1633 | 0.75† | 0.58-0.98 | 68 | 1633 | 1.03 | 0.68-1.56 | 45 | 1565 | 0.59† | 0.36-0.96 | 104 | 1565 | 0.92 | 0.65-1.29 |
Ptrend | 0.11 | 0.94 | 0.49 | 0.99 | ||||||||||||
P§ | 0.34 | 0.44 | 0.10 | 0.53 | ||||||||||||
History of sunburn | ||||||||||||||||
No | 242 | 1548 | 1.00 | 65 | 1548 | 1.00 | 61 | 1548 | 1.00 | 132 | 1548 | 1.00 | ||||
Yes | 488 | 3681 | 0.67† | 0.53-0.84 | 127 | 3681 | 0.92 | 0.59-1.43 | 132 | 3681 | 0.81 | 0.51-1.29 | 335 | 3681 | 0.65† | 0.48-0.89 |
P§ | 0.56 | 0.98 | 0.27 | 0.44 | ||||||||||||
History of sunlamp use | ||||||||||||||||
No | 361 | 3428 | 1.00 | 120 | 3428 | 1.00 | 97 | 3428 | 1.00 | 187 | 3428 | 1.00 | ||||
Yes | 455 | 2501 | 0.85 | 0.70-1.03 | 103 | 2501 | 0.80 | 0.58-1.10 | 111 | 2501 | 0.69 | 0.47-1.02 | 338 | 2501 | 0.88 | 0.68-1.13 |
P§ | 0.32 | 0.72 | 0.10 | 0.98 |