Exposure to UVR and risk of HL by sex and age group
UVR exposure . | Overall . | Sex . | Age group at diagnosis (years) . | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Male . | Female . | <40 . | 40+ . | |||||||||||||||||
Cases (n = 1320) . | Controls (n = 6381) . | OR . | 95% CI . | Cases (n = 722) . | Controls (n = 3518) . | OR . | 95% CI . | Cases (n = 598) . | Controls (n = 2863) . | OR . | 95% CI . | Cases (n = 793) . | Controls (n = 1162) . | OR . | 95% CI . | Cases (n = 527) . | Controls (n = 5219) . | OR . | 95% CI . | |
Overall* | ||||||||||||||||||||
Low | 281 | 1323 | 1.00 | 155 | 682 | 1.00 | 126 | 641 | 1.00 | 154 | 188 | 1.00 | 127 | 1135 | 1.00 | |||||
Low-mid | 316 | 1432 | 0.94 | 0.76-1.16 | 167 | 737 | 0.95 | 0.71-1.26 | 149 | 695 | 0.91 | 0.66-1.25 | 201 | 251 | 1.03 | 0.75-1.41 | 115 | 1181 | 0.89 | 0.59-1.34 |
Mid-high | 309 | 1397 | 0.87 | 0.70-1.08 | 159 | 795 | 0.81 | 0.61-1.09 | 150 | 602 | 0.94 | 0.68-1.30 | 189 | 275 | 0.81 | 0.59-1.11 | 120 | 1122 | 0.93 | 0.69-1.26 |
High | 312 | 1683 | 0.84 | 0.67-1.04 | 192 | 982 | 0.90 | 0.68-1.20 | 120 | 701 | 0.77 | 0.55-1.07 | 182 | 292 | 0.77 | 0.56-1.05 | 130 | 1391 | 0.91 | 0.67-1.22 |
Ptrend† | .01 | .33 | .14 | .09 | .39 | |||||||||||||||
P‡ | .58 | .28 | .07 | .74 | .21 | |||||||||||||||
Childhood | ||||||||||||||||||||
Low | 271 | 1373 | 1.00 | 133 | 610 | 1.00 | 138 | 763 | 1.00 | 166 | 217 | 1.00 | 105 | 1156 | 1.00 | |||||
Low-mid | 306 | 1543 | 0.73§ | 0.59-0.91 | 157 | 861 | 0.61§ | 0.45-0.83 | 149 | 682 | 0.87 | 0.64-1.18 | 228 | 294 | 0.84 | 0.61-1.17 | 78 | 1249 | 0.89 | 0.68-1.18 |
Mid-high | 215 | 1090 | 0.72 | 0.48-1.07 | 109 | 614 | 0.62§ | 0.41-0.95 | 106 | 476 | 0.93 | 0.66-1.29 | 161 | 229 | 0.96 | 0.68-1.36 | 54 | 861 | 0.75§ | 0.55-1.00 |
High | 265 | 1608 | 0.80§ | 0.63-1.00 | 163 | 984 | 0.75 | 0.55-1.01 | 102 | 624 | 0.85 | 0.60-1.20 | 150 | 241 | 0.73 | 0.51-1.06 | 115 | 1367 | 1.04 | 0.79-1.37 |
Ptrend | .41 | .51 | .22 | .25 | .90 | |||||||||||||||
P‡ | .17 | .31 | .07 | .17 | .16 | |||||||||||||||
Adulthood | ||||||||||||||||||||
Low | 339 | 1453 | 1.00 | 191 | 813 | 1.00 | 148 | 942 | 1.00 | 180 | 210 | 1.00 | 159 | 1243 | 1.00 | |||||
Low-mid | 266 | 1492 | 0.80§ | 0.64-1.00 | 142 | 777 | 0.82 | 0.60-1.12 | 124 | 715 | 0.77 | 0.56-1.06 | 137 | 236 | 0.66 | 0.43-1.01 | 129 | 1256 | 0.60§ | 0.44-0.82 |
Mid-high | 260 | 1425 | 0.76§ | 0.61-0.95 | 147 | 798 | 0.73§ | 0.55-0.97 | 113 | 627 | 0.82 | 0.58-1.15 | 147 | 230 | 0.76§ | 0.61-0.95 | 113 | 1195 | 0.67 | 0.39-1.15 |
High | 289 | 1633 | 0.87 | 0.70-1.08 | 176 | 942 | 0.94 | 0.71-1.24 | 113 | 691 | 0.81 | 0.58-1.14 | 134 | 239 | 0.65§ | 0.46-0.93 | 155 | 1394 | 0.90 | 0.67-1.22 |
Ptrend | .51 | .72 | .35 | .26 | .95 | |||||||||||||||
P‡ | .43 | .34 | .22 | .31 | .50 | |||||||||||||||
History of sunburn | ||||||||||||||||||||
No | 356 | 1548 | 1.00 | 210 | 801 | 1.00 | 146 | 747 | 1.00 | 141 | 182 | 1.00 | 215 | 1366 | 1.00 | |||||
Yes | 714 | 3681 | 0.77§ | 0.63-0.95 | 390 | 2077 | 0.77 | 0.57-1.03 | 324 | 1604 | 0.79 | 0.59-1.06 | 459 | 678 | 0.79 | 0.55-1.12 | 255 | 3003 | 0.75§ | 0.58-0.97 |
P‡ | .36 | .26 | .95 | .09 | .26 | |||||||||||||||
History of sunlamp use | ||||||||||||||||||||
No | 588 | 3428 | 1.00 | 391 | 2095 | 1.00 | 197 | 1333 | 1.00 | 302 | 434 | 1.00 | 286 | 2994 | 1.00 | |||||
Yes | 633 | 2501 | 0.81§ | 0.69-0.96 | 285 | 1139 | 0.89 | 0.65-1.23 | 348 | 1362 | 0.81 | 0.63-1.04 | 428 | 586 | 0.79§ | 0.62-1.00 | 205 | 1915 | 0.83 | 0.66-1.04 |
P‡ | .37 | .37 | .45 | .82 | .25 |
UVR exposure . | Overall . | Sex . | Age group at diagnosis (years) . | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Male . | Female . | <40 . | 40+ . | |||||||||||||||||
Cases (n = 1320) . | Controls (n = 6381) . | OR . | 95% CI . | Cases (n = 722) . | Controls (n = 3518) . | OR . | 95% CI . | Cases (n = 598) . | Controls (n = 2863) . | OR . | 95% CI . | Cases (n = 793) . | Controls (n = 1162) . | OR . | 95% CI . | Cases (n = 527) . | Controls (n = 5219) . | OR . | 95% CI . | |
Overall* | ||||||||||||||||||||
Low | 281 | 1323 | 1.00 | 155 | 682 | 1.00 | 126 | 641 | 1.00 | 154 | 188 | 1.00 | 127 | 1135 | 1.00 | |||||
Low-mid | 316 | 1432 | 0.94 | 0.76-1.16 | 167 | 737 | 0.95 | 0.71-1.26 | 149 | 695 | 0.91 | 0.66-1.25 | 201 | 251 | 1.03 | 0.75-1.41 | 115 | 1181 | 0.89 | 0.59-1.34 |
Mid-high | 309 | 1397 | 0.87 | 0.70-1.08 | 159 | 795 | 0.81 | 0.61-1.09 | 150 | 602 | 0.94 | 0.68-1.30 | 189 | 275 | 0.81 | 0.59-1.11 | 120 | 1122 | 0.93 | 0.69-1.26 |
High | 312 | 1683 | 0.84 | 0.67-1.04 | 192 | 982 | 0.90 | 0.68-1.20 | 120 | 701 | 0.77 | 0.55-1.07 | 182 | 292 | 0.77 | 0.56-1.05 | 130 | 1391 | 0.91 | 0.67-1.22 |
Ptrend† | .01 | .33 | .14 | .09 | .39 | |||||||||||||||
P‡ | .58 | .28 | .07 | .74 | .21 | |||||||||||||||
Childhood | ||||||||||||||||||||
Low | 271 | 1373 | 1.00 | 133 | 610 | 1.00 | 138 | 763 | 1.00 | 166 | 217 | 1.00 | 105 | 1156 | 1.00 | |||||
Low-mid | 306 | 1543 | 0.73§ | 0.59-0.91 | 157 | 861 | 0.61§ | 0.45-0.83 | 149 | 682 | 0.87 | 0.64-1.18 | 228 | 294 | 0.84 | 0.61-1.17 | 78 | 1249 | 0.89 | 0.68-1.18 |
Mid-high | 215 | 1090 | 0.72 | 0.48-1.07 | 109 | 614 | 0.62§ | 0.41-0.95 | 106 | 476 | 0.93 | 0.66-1.29 | 161 | 229 | 0.96 | 0.68-1.36 | 54 | 861 | 0.75§ | 0.55-1.00 |
High | 265 | 1608 | 0.80§ | 0.63-1.00 | 163 | 984 | 0.75 | 0.55-1.01 | 102 | 624 | 0.85 | 0.60-1.20 | 150 | 241 | 0.73 | 0.51-1.06 | 115 | 1367 | 1.04 | 0.79-1.37 |
Ptrend | .41 | .51 | .22 | .25 | .90 | |||||||||||||||
P‡ | .17 | .31 | .07 | .17 | .16 | |||||||||||||||
Adulthood | ||||||||||||||||||||
Low | 339 | 1453 | 1.00 | 191 | 813 | 1.00 | 148 | 942 | 1.00 | 180 | 210 | 1.00 | 159 | 1243 | 1.00 | |||||
Low-mid | 266 | 1492 | 0.80§ | 0.64-1.00 | 142 | 777 | 0.82 | 0.60-1.12 | 124 | 715 | 0.77 | 0.56-1.06 | 137 | 236 | 0.66 | 0.43-1.01 | 129 | 1256 | 0.60§ | 0.44-0.82 |
Mid-high | 260 | 1425 | 0.76§ | 0.61-0.95 | 147 | 798 | 0.73§ | 0.55-0.97 | 113 | 627 | 0.82 | 0.58-1.15 | 147 | 230 | 0.76§ | 0.61-0.95 | 113 | 1195 | 0.67 | 0.39-1.15 |
High | 289 | 1633 | 0.87 | 0.70-1.08 | 176 | 942 | 0.94 | 0.71-1.24 | 113 | 691 | 0.81 | 0.58-1.14 | 134 | 239 | 0.65§ | 0.46-0.93 | 155 | 1394 | 0.90 | 0.67-1.22 |
Ptrend | .51 | .72 | .35 | .26 | .95 | |||||||||||||||
P‡ | .43 | .34 | .22 | .31 | .50 | |||||||||||||||
History of sunburn | ||||||||||||||||||||
No | 356 | 1548 | 1.00 | 210 | 801 | 1.00 | 146 | 747 | 1.00 | 141 | 182 | 1.00 | 215 | 1366 | 1.00 | |||||
Yes | 714 | 3681 | 0.77§ | 0.63-0.95 | 390 | 2077 | 0.77 | 0.57-1.03 | 324 | 1604 | 0.79 | 0.59-1.06 | 459 | 678 | 0.79 | 0.55-1.12 | 255 | 3003 | 0.75§ | 0.58-0.97 |
P‡ | .36 | .26 | .95 | .09 | .26 | |||||||||||||||
History of sunlamp use | ||||||||||||||||||||
No | 588 | 3428 | 1.00 | 391 | 2095 | 1.00 | 197 | 1333 | 1.00 | 302 | 434 | 1.00 | 286 | 2994 | 1.00 | |||||
Yes | 633 | 2501 | 0.81§ | 0.69-0.96 | 285 | 1139 | 0.89 | 0.65-1.23 | 348 | 1362 | 0.81 | 0.63-1.04 | 428 | 586 | 0.79§ | 0.62-1.00 | 205 | 1915 | 0.83 | 0.66-1.04 |
P‡ | .37 | .37 | .45 | .82 | .25 |