Cox regression analysis for the estimation of risk prediction of aGVHD in the training phase and validation phase
| . | Training phase . | Validation phase . | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis . | Multivariate analysis . | Univariate analysis . | Multivariate analysis . | |||||
| Hazard ratio . | P . | Hazard ratio . | P . | Hazard ratio . | P . | Hazard ratio . | P . | |
| Age | 1.004 | .720 | 1.007 | .590 | 1.022 | .083 | 1.013 | .327 |
| Malignant (yes/no) | 0.342 | .137 | 0.590 | .516 | 1.069 | .869 | 1.065 | .894 |
| Risk score (low/high) | 0.495 | .019 | 0.670 | .209 | 1.014 | .960 | 1.300 | .384 |
| Donor type (related/unrelated) | 0.630 | .134 | 0.609 | .126 | 0.835 | .504 | 0.971 | .919 |
| Regimen type (nonmyeloablative/myeloablative) | 0.585 | .073 | 0.772 | .469 | 1.385 | .229 | 1.236 | .494 |
| miRNA signature | 1.534 | .001 | 1.524 | .004 | 1.481 | <.001 | 1.478 | <.001 |
| . | Training phase . | Validation phase . | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis . | Multivariate analysis . | Univariate analysis . | Multivariate analysis . | |||||
| Hazard ratio . | P . | Hazard ratio . | P . | Hazard ratio . | P . | Hazard ratio . | P . | |
| Age | 1.004 | .720 | 1.007 | .590 | 1.022 | .083 | 1.013 | .327 |
| Malignant (yes/no) | 0.342 | .137 | 0.590 | .516 | 1.069 | .869 | 1.065 | .894 |
| Risk score (low/high) | 0.495 | .019 | 0.670 | .209 | 1.014 | .960 | 1.300 | .384 |
| Donor type (related/unrelated) | 0.630 | .134 | 0.609 | .126 | 0.835 | .504 | 0.971 | .919 |
| Regimen type (nonmyeloablative/myeloablative) | 0.585 | .073 | 0.772 | .469 | 1.385 | .229 | 1.236 | .494 |
| miRNA signature | 1.534 | .001 | 1.524 | .004 | 1.481 | <.001 | 1.478 | <.001 |
For Cox regression analysis, the reference group is the group that is coded as “0.” For example, for the variable of malignant (Y/N), we code “malignant patients (yes)” as “1” and “no malignant patients (no) as “0.” The group with lower classification is the reference group. “Risk score (low), donor type (related), regimen type (nonmyeloablative)” are reference groups for their variables.