Risk of venous thrombosis for low levels of protein S, stratified analysis with common thrombophilias
| . | . | Patients n (%) . | Controls n (%) . | OR (95% CI)* . |
|---|---|---|---|---|
| Free protein S antigen | Blood group non-O | |||
| 97.5th-2.5th percentile (53-139 U/dL) | Absent | 556 (28.1) | 1270 (45.9) | Reference |
| <2.5th percentile (<53 U/dL) | Absent | 13 (0.7) | 30 (1.1) | 0.93 (0.48-1.79) |
| 97.5th-2.5th percentile (53-139 U/dL) | Present | 1378 (69.7) | 1429 (51.6) | 2.21 (1.95-2.50) |
| <2.5th percentile (<53 U/dL) | Present | 31 (1.6) | 39 (1.4) | 1.71 (1.05-2.78) |
| Total protein S antigen | Blood group non-O | |||
| 97.5th-2.5th percentile (68-146 U/dL) | Absent | 575 (28.1) | 1300 (45.9) | Reference |
| <2.5th percentile (<68 U/dL) | Absent | 13 (0.6) | 32 (1.1) | 0.86 (0.45-1.65) |
| 97.5th-2.5th percentile (68-146 U/dL) | Present | 1418 (69.4) | 1459 (51.5) | 2.20 (1.95-2.49) |
| <2.5th percentile (<68 U/dL) | Present | 37 (1.8) | 40 (1.4) | 2.00 (1.27-3.18) |
| Free protein S antigen | Factor V Leiden | |||
| 97.5th-2.5th percentile (53-139 U/dL) | Absent | 1633 (82.5) | 2578 (92.9) | Reference |
| <2.5th percentile (<53 U/dL) | Absent | 42 (2.1) | 66 (2.4) | 0.94 (0.63-1.40) |
| 97.5th-2.5th percentile (53-139 U/dL) | Present | 303 (15.3) | 127 (4.6) | 3.79 (3.05-4.71) |
| <2.5th percentile (<53 U/dL) | Present | 2 (0.1) | 4 (0.1) | 0.79 (0.14-4.33) |
| Total protein S antigen | Factor V Leiden | |||
| 97.5th-2.5th percentile (68-146 U/dL) | Absent | 1689 (82.6) | 2630 (92.7) | Reference |
| <2.5th percentile (<68 U/dL) | Absent | 44 (2.2) | 69 (2.4) | 0.94 (0.64-1.39) |
| 97.5th-2.5th percentile (68-146 U/dL) | Present | 307 (15.0) | 136 (4.8) | 3.35 (2.86-4.37) |
| <2.5th percentile (<68 U/dL) | Present | 6 (0.3) | 3 (0.1) | 2.99 (0.75-12.0) |
| Free protein S antigen | Prothrombin G20210A | |||
| 97.5th-2.5th percentile (53-139 U/dL) | Absent | 1843 (93.0) | 2658 (958) | Reference |
| <2.5th percentile (<53 U/dL) | Absent | 42 (2.2) | 69 (2.5) | 0.84 (0.57-1.24) |
| 97.5th-2.5th percentile (53-139 U/dL) | Present | 94 (4.7) | 47 (1.7) | 2.87 (2.01-4.09) |
| <2.5th percentile (<53 U/dL) | Present | 1 (0.1) | 1 (0.0) | 1.46 (0.09-23.4) |
| Total protein S antigen | Prothrombin G20210A | |||
| 97.5th-2.5th percentile (68-146 U/dL) | Absent | 1905 (93.1) | 2718 (95.8) | Reference |
| <2.5th percentile (<68 U/dL) | Absent | 48 (2.3) | 70 (2.5) | 0.93 (0.61-1.35) |
| 97.5th-2.5th percentile (68-146 U/dL) | Present | 92 (4.5) | 48 (1.7) | 2.73 (1.92-3.89) |
| <2.5th percentile (<68 U/dL) | Present | 2 (0.1) | 2 (0.1) | 1.37 (0.19-9.78) |
| . | . | Patients n (%) . | Controls n (%) . | OR (95% CI)* . |
|---|---|---|---|---|
| Free protein S antigen | Blood group non-O | |||
| 97.5th-2.5th percentile (53-139 U/dL) | Absent | 556 (28.1) | 1270 (45.9) | Reference |
| <2.5th percentile (<53 U/dL) | Absent | 13 (0.7) | 30 (1.1) | 0.93 (0.48-1.79) |
| 97.5th-2.5th percentile (53-139 U/dL) | Present | 1378 (69.7) | 1429 (51.6) | 2.21 (1.95-2.50) |
| <2.5th percentile (<53 U/dL) | Present | 31 (1.6) | 39 (1.4) | 1.71 (1.05-2.78) |
| Total protein S antigen | Blood group non-O | |||
| 97.5th-2.5th percentile (68-146 U/dL) | Absent | 575 (28.1) | 1300 (45.9) | Reference |
| <2.5th percentile (<68 U/dL) | Absent | 13 (0.6) | 32 (1.1) | 0.86 (0.45-1.65) |
| 97.5th-2.5th percentile (68-146 U/dL) | Present | 1418 (69.4) | 1459 (51.5) | 2.20 (1.95-2.49) |
| <2.5th percentile (<68 U/dL) | Present | 37 (1.8) | 40 (1.4) | 2.00 (1.27-3.18) |
| Free protein S antigen | Factor V Leiden | |||
| 97.5th-2.5th percentile (53-139 U/dL) | Absent | 1633 (82.5) | 2578 (92.9) | Reference |
| <2.5th percentile (<53 U/dL) | Absent | 42 (2.1) | 66 (2.4) | 0.94 (0.63-1.40) |
| 97.5th-2.5th percentile (53-139 U/dL) | Present | 303 (15.3) | 127 (4.6) | 3.79 (3.05-4.71) |
| <2.5th percentile (<53 U/dL) | Present | 2 (0.1) | 4 (0.1) | 0.79 (0.14-4.33) |
| Total protein S antigen | Factor V Leiden | |||
| 97.5th-2.5th percentile (68-146 U/dL) | Absent | 1689 (82.6) | 2630 (92.7) | Reference |
| <2.5th percentile (<68 U/dL) | Absent | 44 (2.2) | 69 (2.4) | 0.94 (0.64-1.39) |
| 97.5th-2.5th percentile (68-146 U/dL) | Present | 307 (15.0) | 136 (4.8) | 3.35 (2.86-4.37) |
| <2.5th percentile (<68 U/dL) | Present | 6 (0.3) | 3 (0.1) | 2.99 (0.75-12.0) |
| Free protein S antigen | Prothrombin G20210A | |||
| 97.5th-2.5th percentile (53-139 U/dL) | Absent | 1843 (93.0) | 2658 (958) | Reference |
| <2.5th percentile (<53 U/dL) | Absent | 42 (2.2) | 69 (2.5) | 0.84 (0.57-1.24) |
| 97.5th-2.5th percentile (53-139 U/dL) | Present | 94 (4.7) | 47 (1.7) | 2.87 (2.01-4.09) |
| <2.5th percentile (<53 U/dL) | Present | 1 (0.1) | 1 (0.0) | 1.46 (0.09-23.4) |
| Total protein S antigen | Prothrombin G20210A | |||
| 97.5th-2.5th percentile (68-146 U/dL) | Absent | 1905 (93.1) | 2718 (95.8) | Reference |
| <2.5th percentile (<68 U/dL) | Absent | 48 (2.3) | 70 (2.5) | 0.93 (0.61-1.35) |
| 97.5th-2.5th percentile (68-146 U/dL) | Present | 92 (4.5) | 48 (1.7) | 2.73 (1.92-3.89) |
| <2.5th percentile (<68 U/dL) | Present | 2 (0.1) | 2 (0.1) | 1.37 (0.19-9.78) |
Adjusted for age and gender.