Risk of venous thrombosis for strata of protein S levels
| Measurement . | Patients n (%) . | Controls n (%) . | Total OR (95% CI)* . | |
|---|---|---|---|---|
| Overall . | Overall minus† . | |||
| Free protein S antigen | ||||
| 97.5th-75th percentile (105-139 U/dL) | 511 (25.8) | 617 (22.2) | Reference | Reference |
| 50th-75th percentile (91-105 U/dL) | 528 (26.7) | 692 (25.0) | 0.85 (0.72-1.00) | 0.77 (0.64-0.92) |
| 25th-50th percentile (77-91 U/dL) | 507 (25.6) | 738 (26.6) | 0.81 (0.69-0.96) | 0.70 (0.57-0.85) |
| 10-25th percentile (77-66 U/dL) | 291 (14.7) | 449 (16.1) | 0.75 (0.61-0.92) | 0.55 (0.43-0.72) |
| <10th percentile (<66 U/dL) | 144 (7.2) | 279 (10.0) | 0.61 (0.45-0.85) | 0.53 (0.33-0.83) |
| Total protein S antigen | ||||
| 97.5th-75th percentile (115-146 U/dL) | 498 (24.3) | 653 (23.0) | Reference | Reference |
| 50th-75th percentile (101-115 U/dL) | 573 (28.0) | 720 (25.4) | 1.02 (0.86-1.19) | 0.99 (0.82-1.19) |
| 25th-50th percentile (89-101 U/dL) | 500 (24.4) | 723 (25.5) | 0.85 (0.72-1.01) | 0.73 (0.60-0.89) |
| 10-25th percentile (78-89 U/dL) | 296 (14.5) | 470 (16.6) | 0.79 (0.65-0.97) | 0.68 (0.53-0.88) |
| <10th percentile (<78 U/dL) | 180 (8.8) | 272 (9.6) | 0.86 (0.63-1.16) | 0.78 (0.51-1.20) |
| Measurement . | Patients n (%) . | Controls n (%) . | Total OR (95% CI)* . | |
|---|---|---|---|---|
| Overall . | Overall minus† . | |||
| Free protein S antigen | ||||
| 97.5th-75th percentile (105-139 U/dL) | 511 (25.8) | 617 (22.2) | Reference | Reference |
| 50th-75th percentile (91-105 U/dL) | 528 (26.7) | 692 (25.0) | 0.85 (0.72-1.00) | 0.77 (0.64-0.92) |
| 25th-50th percentile (77-91 U/dL) | 507 (25.6) | 738 (26.6) | 0.81 (0.69-0.96) | 0.70 (0.57-0.85) |
| 10-25th percentile (77-66 U/dL) | 291 (14.7) | 449 (16.1) | 0.75 (0.61-0.92) | 0.55 (0.43-0.72) |
| <10th percentile (<66 U/dL) | 144 (7.2) | 279 (10.0) | 0.61 (0.45-0.85) | 0.53 (0.33-0.83) |
| Total protein S antigen | ||||
| 97.5th-75th percentile (115-146 U/dL) | 498 (24.3) | 653 (23.0) | Reference | Reference |
| 50th-75th percentile (101-115 U/dL) | 573 (28.0) | 720 (25.4) | 1.02 (0.86-1.19) | 0.99 (0.82-1.19) |
| 25th-50th percentile (89-101 U/dL) | 500 (24.4) | 723 (25.5) | 0.85 (0.72-1.01) | 0.73 (0.60-0.89) |
| 10-25th percentile (78-89 U/dL) | 296 (14.5) | 470 (16.6) | 0.79 (0.65-0.97) | 0.68 (0.53-0.88) |
| <10th percentile (<78 U/dL) | 180 (8.8) | 272 (9.6) | 0.86 (0.63-1.16) | 0.78 (0.51-1.20) |