Clinical characteristics
| . | Patients in MEGA (n = 4956) . | Patients tested (n = 2377)* . | Controls in MEGA (n = 6297) . | Controls tested (n = 2940) . |
|---|---|---|---|---|
| Male | 2274 (46) | 1083 (46) | 2914 (46) | 1393 (47) |
| Age at enrollment | 49 (13) | 48 (13) | 47 (13) | 48 (12) |
| Vitamin K antagonist use† | 294 (6) | 288 (12) | 34 (0.5) | 30 (1.0) |
| Estrogen use (women) | 1384 (54) | 739 (58) | 934 (29) | 412 (27) |
| Pregnancy/puerperium (women) | 183 (7) | 94 (7) | 87 (3) | 29 (2) |
| Normal weight (BMI 18.5-25 kg/m2) | 1634 (37) | 818 (37) | 2805 (49) | 1354 (48) |
| Overweight (BMI 25-30 kg/m2) | 1834 (42) | 965 (43) | 2112 (37) | 1109 (39) |
| Obesity (BMI ≥ 30 kg/m2) | 907 (21) | 456 (20) | 763 (13) | 365 (13) |
| . | Patients in MEGA (n = 4956) . | Patients tested (n = 2377)* . | Controls in MEGA (n = 6297) . | Controls tested (n = 2940) . |
|---|---|---|---|---|
| Male | 2274 (46) | 1083 (46) | 2914 (46) | 1393 (47) |
| Age at enrollment | 49 (13) | 48 (13) | 47 (13) | 48 (12) |
| Vitamin K antagonist use† | 294 (6) | 288 (12) | 34 (0.5) | 30 (1.0) |
| Estrogen use (women) | 1384 (54) | 739 (58) | 934 (29) | 412 (27) |
| Pregnancy/puerperium (women) | 183 (7) | 94 (7) | 87 (3) | 29 (2) |
| Normal weight (BMI 18.5-25 kg/m2) | 1634 (37) | 818 (37) | 2805 (49) | 1354 (48) |
| Overweight (BMI 25-30 kg/m2) | 1834 (42) | 965 (43) | 2112 (37) | 1109 (39) |
| Obesity (BMI ≥ 30 kg/m2) | 907 (21) | 456 (20) | 763 (13) | 365 (13) |
Continuous variables denoted as mean (standard deviation), categorical data as count (%). Data were missing for some participants in some subgroups.
BMI, body mass index.
There were slightly less patients (n = 2331) and controls (n = 2872) tested on free protein S due to sampling errors.
At time of blood draw.