Subanalysis of double HLA mismatch combinations after multivariate modeling
| Mismatch combination . | n . | HR . | 95% CI . | P . |
|---|---|---|---|---|
| OS | ||||
| Complete match | 1511 | 1.00 | ||
| Double MM HLA class I+II | 67 | 2.20 | 1.60-3.03 | <.001 |
| Double MM only HLA class I | 162 | 1.68 | 1.27-2.22 | <.001 |
| Double MM only HLA class II | 18 | 1.83 | 1.04-3.22 | .036 |
| DFS | ||||
| Complete match | 1511 | 1.00 | ||
| Double MM HLA class I+II | 67 | 2.03 | 1.50-2.74 | <.001 |
| Double MM only HLA class I | 162 | 1.55 | 1.19-2.02 | .001 |
| Double MM only HLA class II | 18 | 1.57 | 0.89-2.75 | .120 |
| TRM | ||||
| Complete match | 1509 | 1.00 | ||
| Double MM HLA class I+II | 67 | 2.69 | 1.75-4.14 | <.001 |
| Double MM only HLA class I | 162 | 1.90 | 1.39-2.61 | <.001 |
| Double MM only HLA class II | 18 | 1.52 | 0.63-3.67 | .360 |
| Mismatch combination . | n . | HR . | 95% CI . | P . |
|---|---|---|---|---|
| OS | ||||
| Complete match | 1511 | 1.00 | ||
| Double MM HLA class I+II | 67 | 2.20 | 1.60-3.03 | <.001 |
| Double MM only HLA class I | 162 | 1.68 | 1.27-2.22 | <.001 |
| Double MM only HLA class II | 18 | 1.83 | 1.04-3.22 | .036 |
| DFS | ||||
| Complete match | 1511 | 1.00 | ||
| Double MM HLA class I+II | 67 | 2.03 | 1.50-2.74 | <.001 |
| Double MM only HLA class I | 162 | 1.55 | 1.19-2.02 | .001 |
| Double MM only HLA class II | 18 | 1.57 | 0.89-2.75 | .120 |
| TRM | ||||
| Complete match | 1509 | 1.00 | ||
| Double MM HLA class I+II | 67 | 2.69 | 1.75-4.14 | <.001 |
| Double MM only HLA class I | 162 | 1.90 | 1.39-2.61 | <.001 |
| Double MM only HLA class II | 18 | 1.52 | 0.63-3.67 | .360 |
Analysis of OS, DFS, and TRM in different mismatch groups. Significance level set to P < .01. Significant results are bold.