Subanalysis of mismatch combinations after multivariate modeling
| Mismatch combination . | n . | HR . | 95% CI . | P . |
|---|---|---|---|---|
| OS | ||||
| Complete match | 1511 | 1.00 | ||
| Single allele MM | 304 | 1.21 | 1.01-1.44 | .044 |
| Single antigen MM | 499 | 1.30 | 1.12-1.51 | <.001 |
| Double allele MM | 46 | 1.70 | 1.15-2.53 | .008 |
| Double MM allele + antigen | 139 | 2.04 | 1.54-2.69 | <.001 |
| Double antigen MM | 62 | 1.76 | 1.25-2.48 | .001 |
| Triple MM | 61 | 2.56 | 1.71-3.85 | <.001 |
| Multiple MM | 24 | 3.11 | 1.70-5.67 | <.001 |
| DFS | ||||
| Complete match | 1511 | 1.00 | ||
| Single allele MM | 304 | 1.11 | 0.93-1.31 | .240 |
| Single antigen MM | 499 | 1.21 | 1.05-1.39 | .009 |
| Double allele MM | 46 | 1.60 | 1.09-2.33 | .015 |
| Double MM allele + antigen | 139 | 1.75 | 1.34-2.27 | <.001 |
| Double antigen MM | 62 | 1.75 | 1.27-2.41 | <.001 |
| Triple MM | 61 | 2.03 | 1.37-3.03 | <.001 |
| Multiple MM | 24 | 2.17 | 1.22-3.88 | .009 |
| TRM | ||||
| Complete match | 1509 | 1.00 | ||
| Single allele MM | 304 | 1.46 | 1.14-1.87 | .003 |
| Single antigen MM | 499 | 1.34 | 1.08-1.66 | .007 |
| Double allele MM | 46 | 2.08 | 1.21-3.57 | .008 |
| Double MM allele + antigen | 139 | 2.16 | 1.57-2.99 | <.001 |
| Double antigen MM | 62 | 1.90 | 1.18-3.07 | .009 |
| Triple MM | 61 | 2.94 | 1.91-4.51 | <.001 |
| Multiple MM | 24 | 2.93 | 1.66-5.16 | <.001 |
| Mismatch combination . | n . | HR . | 95% CI . | P . |
|---|---|---|---|---|
| OS | ||||
| Complete match | 1511 | 1.00 | ||
| Single allele MM | 304 | 1.21 | 1.01-1.44 | .044 |
| Single antigen MM | 499 | 1.30 | 1.12-1.51 | <.001 |
| Double allele MM | 46 | 1.70 | 1.15-2.53 | .008 |
| Double MM allele + antigen | 139 | 2.04 | 1.54-2.69 | <.001 |
| Double antigen MM | 62 | 1.76 | 1.25-2.48 | .001 |
| Triple MM | 61 | 2.56 | 1.71-3.85 | <.001 |
| Multiple MM | 24 | 3.11 | 1.70-5.67 | <.001 |
| DFS | ||||
| Complete match | 1511 | 1.00 | ||
| Single allele MM | 304 | 1.11 | 0.93-1.31 | .240 |
| Single antigen MM | 499 | 1.21 | 1.05-1.39 | .009 |
| Double allele MM | 46 | 1.60 | 1.09-2.33 | .015 |
| Double MM allele + antigen | 139 | 1.75 | 1.34-2.27 | <.001 |
| Double antigen MM | 62 | 1.75 | 1.27-2.41 | <.001 |
| Triple MM | 61 | 2.03 | 1.37-3.03 | <.001 |
| Multiple MM | 24 | 2.17 | 1.22-3.88 | .009 |
| TRM | ||||
| Complete match | 1509 | 1.00 | ||
| Single allele MM | 304 | 1.46 | 1.14-1.87 | .003 |
| Single antigen MM | 499 | 1.34 | 1.08-1.66 | .007 |
| Double allele MM | 46 | 2.08 | 1.21-3.57 | .008 |
| Double MM allele + antigen | 139 | 2.16 | 1.57-2.99 | <.001 |
| Double antigen MM | 62 | 1.90 | 1.18-3.07 | .009 |
| Triple MM | 61 | 2.94 | 1.91-4.51 | <.001 |
| Multiple MM | 24 | 2.93 | 1.66-5.16 | <.001 |
Analysis of OS, DFS, and TRM in different mismatch groups. Multiple mismatches, >3 HLA mismatches. Significance level set to P < .01. Significant results are bold.