Analysis of the impact of HLA mismatches in all transplantations after multivariate modeling
| Locus . | n . | HR . | 95% CI . | P . |
|---|---|---|---|---|
| OS | ||||
| Complete match | 1511 | 1.00 | ||
| HLA-A allele MM | 121 | 1.37 | 1.04-1.80 | .026 |
| HLA-A antigen MM | 164 | 1.41 | 1.12-1.77 | .003 |
| HLA-B allele MM | 237 | 1.48 | 1.15-1.91 | .003 |
| HLA-B-antigen MM | 50 | 1.48 | 1.00-2.20 | .052 |
| HLA-C allele MM | 106 | 1.28 | 0.98-1.67 | .072 |
| HLA-C antigen MM | 528 | 1.34 | 1.15-1.57 | <.001 |
| HLA-DRB1 allele MM | 108 | 1.46 | 1.12-1.90 | .005 |
| HLA-DRB1 antigen MM | 18 | 1.12 | 0.57-2.17 | .750 |
| HLA-DQB1 allele MM | 107 | 1.10 | 0.84-1.45 | .480 |
| HLA-DQB1 antigen MM | 85 | 1.39 | 1.04-1.85 | .028 |
| DFS | ||||
| Complete match | 1511 | 1.00 | ||
| HLA-A allele MM | 121 | 1.22 | 0.94-1.59 | .140 |
| HLA-A antigen MM | 164 | 1.23 | 0.98-1.53 | .070 |
| HLA-B allele MM | 237 | 1.33 | 1.04-1.69 | .024 |
| HLA-B-antigen MM | 50 | 1.20 | 0.81-1.77 | .370 |
| HLA-C allele MM | 106 | 1.20 | 0.93-1.55 | .150 |
| HLA-C antigen MM | 528 | 1.32 | 1.14-1.52 | <.001 |
| HLA-DRB1 allele MM | 108 | 1.38 | 1.07-1.77 | .014 |
| HLA-DRB1 antigen MM | 18 | 0.87 | 0.45-1.69 | .670 |
| HLA-DQB1 allele MM | 107 | 1.06 | 0.81-1.37 | .690 |
| HLA-DQB1 antigen MM | 85 | 1.34 | 1.02-1.77 | .036 |
| TRM | ||||
| Complete match | 1509 | 1.00 | ||
| HLA-A allele MM | 121 | 1.22 | 0.80-1.86 | .360 |
| HLA-A antigen MM | 164 | 1.64 | 1.21-2.22 | .002 |
| HLA-B allele MM | 237 | 1.62 | 1.26-2.08 | <.001 |
| HLA-B-antigen MM | 50 | 1.07 | 0.61-1.89 | .810 |
| HLA-C allele MM | 106 | 1.55 | 1.09-2.21 | .015 |
| HLA-C antigen MM | 528 | 1.38 | 1.12-1.69 | .002 |
| HLA-DRB1 allele MM | 108 | 1.68 | 1.17-2.40 | .005 |
| HLA-DRB1 antigen MM | 18 | 0.71 | 0.22-2.30 | .570 |
| HLA-DQB1 allele MM | 107 | 1.27 | 0.88-1.82 | .200 |
| HLA-DQB1 antigen MM | 85 | 1.25 | 0.82-1.89 | .300 |
| Locus . | n . | HR . | 95% CI . | P . |
|---|---|---|---|---|
| OS | ||||
| Complete match | 1511 | 1.00 | ||
| HLA-A allele MM | 121 | 1.37 | 1.04-1.80 | .026 |
| HLA-A antigen MM | 164 | 1.41 | 1.12-1.77 | .003 |
| HLA-B allele MM | 237 | 1.48 | 1.15-1.91 | .003 |
| HLA-B-antigen MM | 50 | 1.48 | 1.00-2.20 | .052 |
| HLA-C allele MM | 106 | 1.28 | 0.98-1.67 | .072 |
| HLA-C antigen MM | 528 | 1.34 | 1.15-1.57 | <.001 |
| HLA-DRB1 allele MM | 108 | 1.46 | 1.12-1.90 | .005 |
| HLA-DRB1 antigen MM | 18 | 1.12 | 0.57-2.17 | .750 |
| HLA-DQB1 allele MM | 107 | 1.10 | 0.84-1.45 | .480 |
| HLA-DQB1 antigen MM | 85 | 1.39 | 1.04-1.85 | .028 |
| DFS | ||||
| Complete match | 1511 | 1.00 | ||
| HLA-A allele MM | 121 | 1.22 | 0.94-1.59 | .140 |
| HLA-A antigen MM | 164 | 1.23 | 0.98-1.53 | .070 |
| HLA-B allele MM | 237 | 1.33 | 1.04-1.69 | .024 |
| HLA-B-antigen MM | 50 | 1.20 | 0.81-1.77 | .370 |
| HLA-C allele MM | 106 | 1.20 | 0.93-1.55 | .150 |
| HLA-C antigen MM | 528 | 1.32 | 1.14-1.52 | <.001 |
| HLA-DRB1 allele MM | 108 | 1.38 | 1.07-1.77 | .014 |
| HLA-DRB1 antigen MM | 18 | 0.87 | 0.45-1.69 | .670 |
| HLA-DQB1 allele MM | 107 | 1.06 | 0.81-1.37 | .690 |
| HLA-DQB1 antigen MM | 85 | 1.34 | 1.02-1.77 | .036 |
| TRM | ||||
| Complete match | 1509 | 1.00 | ||
| HLA-A allele MM | 121 | 1.22 | 0.80-1.86 | .360 |
| HLA-A antigen MM | 164 | 1.64 | 1.21-2.22 | .002 |
| HLA-B allele MM | 237 | 1.62 | 1.26-2.08 | <.001 |
| HLA-B-antigen MM | 50 | 1.07 | 0.61-1.89 | .810 |
| HLA-C allele MM | 106 | 1.55 | 1.09-2.21 | .015 |
| HLA-C antigen MM | 528 | 1.38 | 1.12-1.69 | .002 |
| HLA-DRB1 allele MM | 108 | 1.68 | 1.17-2.40 | .005 |
| HLA-DRB1 antigen MM | 18 | 0.71 | 0.22-2.30 | .570 |
| HLA-DQB1 allele MM | 107 | 1.27 | 0.88-1.82 | .200 |
| HLA-DQB1 antigen MM | 85 | 1.25 | 0.82-1.89 | .300 |
Analysis of OS, DFS, and TRM with allele and antigen mismatches separated. Significance level set to P < .01. Significant results are bold.
n, number of individuals within the respective category; MM, mismatch.