Analysis of the impact of HLA mismatches in all transplantations after multivariate modeling
| Locus . | n . | HR . | 95% CI . | P . |
|---|---|---|---|---|
| OS | ||||
| Complete match | 1511 | 1.00 | ||
| HLA-A MM | 282 | 1.43 | 1.19-1.72 | <.001 |
| HLA-B MM | 283 | 1.52 | 1.20-1.93 | <.001 |
| HLA-C MM | 620 | 1.35 | 1.17-1.56 | <.001 |
| HLA-DRB1 MM | 126 | 1.42 | 1.10-1.82 | .006 |
| HLA-DQB1 MM | 191 | 1.23 | 1.00-1.51 | .050 |
| DFS | ||||
| Complete match | 1511 | 1.00 | ||
| HLA-A MM | 282 | 1.25 | 1.05-1.50 | .014 |
| HLA-B MM | 283 | 1.32 | 1.05-1.66 | .016 |
| HLA-C MM | 620 | 1.32 | 1.15-1.51 | <.001 |
| HLA-DRB1 MM | 126 | 1.29 | 1.01-1.63 | .040 |
| HLA-DQB1 MM | 191 | 1.18 | 0.97-1.43 | .110 |
| TRM | ||||
| Complete match | 1509 | 1.00 | ||
| HLA-A MM | 282 | 1.51 | 1.16-1.98 | .003 |
| HLA-B MM | 283 | 1.50 | 1.19-1.89 | <.001 |
| HLA-C MM | 620 | 1.45 | 1.19-1.76 | <.001 |
| HLA-DRB1 MM | 126 | 1.57 | 1.12-2.21 | .009 |
| HLA-DQB1 MM | 191 | 1.28 | 0.96-1.71 | .091 |
| Locus . | n . | HR . | 95% CI . | P . |
|---|---|---|---|---|
| OS | ||||
| Complete match | 1511 | 1.00 | ||
| HLA-A MM | 282 | 1.43 | 1.19-1.72 | <.001 |
| HLA-B MM | 283 | 1.52 | 1.20-1.93 | <.001 |
| HLA-C MM | 620 | 1.35 | 1.17-1.56 | <.001 |
| HLA-DRB1 MM | 126 | 1.42 | 1.10-1.82 | .006 |
| HLA-DQB1 MM | 191 | 1.23 | 1.00-1.51 | .050 |
| DFS | ||||
| Complete match | 1511 | 1.00 | ||
| HLA-A MM | 282 | 1.25 | 1.05-1.50 | .014 |
| HLA-B MM | 283 | 1.32 | 1.05-1.66 | .016 |
| HLA-C MM | 620 | 1.32 | 1.15-1.51 | <.001 |
| HLA-DRB1 MM | 126 | 1.29 | 1.01-1.63 | .040 |
| HLA-DQB1 MM | 191 | 1.18 | 0.97-1.43 | .110 |
| TRM | ||||
| Complete match | 1509 | 1.00 | ||
| HLA-A MM | 282 | 1.51 | 1.16-1.98 | .003 |
| HLA-B MM | 283 | 1.50 | 1.19-1.89 | <.001 |
| HLA-C MM | 620 | 1.45 | 1.19-1.76 | <.001 |
| HLA-DRB1 MM | 126 | 1.57 | 1.12-2.21 | .009 |
| HLA-DQB1 MM | 191 | 1.28 | 0.96-1.71 | .091 |
Analysis of OS, DFS, and TRM for any mismatch at each locus. Significance level set to P < .01. Significant results are bold.