Significant risk factors for sexual function domains and sexual satisfaction at pre- and post-HCT in men
| Covariate* . | Percent change† (ES)‡ . | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Derogatis Index of Sexual Function domains . | Sexual satisfaction . | |||||||||||||
| Sexual cognition/fantasy . | Sexual arousal . | Sexual behavior/experience . | Orgasm . | Drive/Relationship . | Total sexual function . | |||||||||
| Pre . | Post . | Pre . | Post . | Pre . | Post . | Pre . | Post . | Pre . | Post . | Pre . | Post . | Pre . | Post . | |
| Age at referent HCT (per 10 y increase) | −18.4§ (.33) | −17.3§ (.33) | −25.0§ (.27) | −23.0§ (.26) | −19.7|| (.24) | −19.0|| (.27) | −15.6§ (.29) | −18.9§ (.32) | −16.1§ (.40) | −12.1§ (.35) | −16.3§ (.34) | −16.7§ (.36) | −16.7§ (.23) | −17.1§ (.31) |
| Non-Hispanic white (vs other) | – | – | – | – | – | – | – | – | – | – | – | – | – | 23.3|| (.38) |
| Married (vs not married) | – | −13.1¶ (.27) | −42.4|| (.67) | −34.0|| (.51) | – | – | – | – | – | – | −14.0¶ (.33) | – | – | – |
| Annual household income (per $10 000 increase) | – | – | 5.0|| (.05) | – | – | – | – | – | – | – | – | – | – | 2.5¶ (.04) |
| Highest education level at time of referent HCT (per year increase) | 4.1§ (.07) | – | – | – | – | – | – | – | – | – | 2.1¶ (.04) | – | – | – |
| BMI (kg/m2) at pre-HCT (per unit increase) | – | – | – | – | – | – | – | – | – | – | 1.7¶ (.03) | 1.7¶ (.04) | – | – |
| Change in BMI from pre-HCT level#** (per unit increase) | NA | 2.0¶ (.04) | NA | – | NA | 2.2¶ (.03) | NA | 2.9|| (.05) | NA | 1.9|| (.05) | NA | 2.7¶ (.06) | NA | 2.5¶ (.03) |
| Allogeneic stem cell source†† (vs autologous stem cell source) | – | −15.8¶ (.32) | – | – | – | – | – | −18.9|| (.32) | – | – | – | – | – | – |
| Chronic GVHD#‡‡ (vs no chronic GVHD) | NA | −21.2|| (.42) | NA | – | NA | – | NA | −24.4|| (.43) | NA | – | NA | – | NA | – |
| TBI (vs no TBI) | NA | −13.0¶ (.26) | NA | – | NA | −25.7¶ (.40) | NA | −26.1|| (.49) | NA | −17.1|| (.52) | NA | −17.5|| (.39) | NA | −31.5§ (.64) |
| Covariate* . | Percent change† (ES)‡ . | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Derogatis Index of Sexual Function domains . | Sexual satisfaction . | |||||||||||||
| Sexual cognition/fantasy . | Sexual arousal . | Sexual behavior/experience . | Orgasm . | Drive/Relationship . | Total sexual function . | |||||||||
| Pre . | Post . | Pre . | Post . | Pre . | Post . | Pre . | Post . | Pre . | Post . | Pre . | Post . | Pre . | Post . | |
| Age at referent HCT (per 10 y increase) | −18.4§ (.33) | −17.3§ (.33) | −25.0§ (.27) | −23.0§ (.26) | −19.7|| (.24) | −19.0|| (.27) | −15.6§ (.29) | −18.9§ (.32) | −16.1§ (.40) | −12.1§ (.35) | −16.3§ (.34) | −16.7§ (.36) | −16.7§ (.23) | −17.1§ (.31) |
| Non-Hispanic white (vs other) | – | – | – | – | – | – | – | – | – | – | – | – | – | 23.3|| (.38) |
| Married (vs not married) | – | −13.1¶ (.27) | −42.4|| (.67) | −34.0|| (.51) | – | – | – | – | – | – | −14.0¶ (.33) | – | – | – |
| Annual household income (per $10 000 increase) | – | – | 5.0|| (.05) | – | – | – | – | – | – | – | – | – | – | 2.5¶ (.04) |
| Highest education level at time of referent HCT (per year increase) | 4.1§ (.07) | – | – | – | – | – | – | – | – | – | 2.1¶ (.04) | – | – | – |
| BMI (kg/m2) at pre-HCT (per unit increase) | – | – | – | – | – | – | – | – | – | – | 1.7¶ (.03) | 1.7¶ (.04) | – | – |
| Change in BMI from pre-HCT level#** (per unit increase) | NA | 2.0¶ (.04) | NA | – | NA | 2.2¶ (.03) | NA | 2.9|| (.05) | NA | 1.9|| (.05) | NA | 2.7¶ (.06) | NA | 2.5¶ (.03) |
| Allogeneic stem cell source†† (vs autologous stem cell source) | – | −15.8¶ (.32) | – | – | – | – | – | −18.9|| (.32) | – | – | – | – | – | – |
| Chronic GVHD#‡‡ (vs no chronic GVHD) | NA | −21.2|| (.42) | NA | – | NA | – | NA | −24.4|| (.43) | NA | – | NA | – | NA | – |
| TBI (vs no TBI) | NA | −13.0¶ (.26) | NA | – | NA | −25.7¶ (.40) | NA | −26.1|| (.49) | NA | −17.1|| (.52) | NA | −17.5|| (.39) | NA | −31.5§ (.64) |
– indicates statistically nonsignificant covariate (P > .05) (percent change and ES are therefore not shown); NA, not applicable.
Referent groups are shown in parentheses. Other factors examined that were nonsignificant in the multivariate GEE regression include stem cell source, number of transplantation, BMI corresponding to assessment times and at baseline.
Percent change is calculated as [(model-based expected level of the index group – model-based expected level of the referent group)/(expected level of the referent group)] × 100. For age and BMI, expected levels corresponding to their means at the pre-HCT time point were used as referent levels. For post-HCT, the average of the 4 time points is reported. Positive percent change indicates more favorable QOL in the index group. Results are adjusted for disease type, if significant.
Effect size (ES) at a time point is computed as the absolute value of (expected level of the index group − expected level of the referent group)/observed common SD at that time point. At post-HCT, the average effect size of the 4 time points is reported.
Value of P < .0001.
Value of P < .01.
Value of P < .05.
Time varying: values concurrent to sexual function scores were used.
BMI at follow-up minus BMI at pre-HCT.
Effects shown are without chronic GVHD in the model. The effect of stem cell source is nonsignificant when chronic GVHD is included in the multivariate model.
Self-reported.