Characteristics of the arteriovenous fresh profile gene list
| Characteristic . | Number of genes . | Gene names . |
|---|---|---|
| Knockout mouse has a vascular phenotype* | 13 | COL4A1, COL4A2, CUBN, CYSLTR1, EMX2, FGL2, HEY2, KDR, MSX1, NKX2-3, NOTCH4, SEMA3C, SOX17 |
| Previously associated with cardiovascular disease or risk factors in humans† | 7 | ARL15, CNTN3, COL4A1, GRB14, MFAP5, NPR3, TOX2 |
| Coding for cell surface protein | 22 | A2M, ACE2, ADRB1, CNTN3, CYSLTR1, FAP, FAT1, FOLH1, KDR, NOTCH4, NPR3, NRCAM, PTPRR, SLC2A1, SLC2A3, SYTL2, XG, FLRT3, MPP7, NOS1, TMEM200A, TMEM200C |
| Coding for secreted protein | 14 | CCDC3, COL4A1, COL4A2, FAM19A5, FGL2, FREM1, LAMA2, MFAP5, ODAM, SEMA3C, SEMA3G, TFPI2, OLFML3, PAPLN |
| Coding for intracellular protein | 27 | AFF3, APO, CUBN, EMX2, FAM176A, GALNTL4, GLIPR2, GRB14, HECW2, HEY2, KLHL6, LMCD1, MAP9, MSX1, NAV1, NKX2-3, PDE4D, PRDM16, PSMAL, RGC-32, RYR3, SOX17, TOX2, CMBL, MGST1, SCARA3, SNTB2 |
| Coding for TF | 9 | AFF3, EMX2, HEY2, MSX1, NKX2-3, PRDM16, SOX17, TOX2, NR3C2 |
| Documented expression in aECs and/or vECs | 16 | APO, CCDC3, COL4A1, COL4A2, CYSLTR1, GLIPR2, HEY2, KDR, MFAP5, MSX1, NKX2-3, NOTCH4, RGC-32, SEMA3G, SOX17, NR3C2 |
| Previously associated with arteriovenous specification | 4 | HEY2, KDR, NOTCH4, S0X17 |
| Previously linked with the Notch pathway† | 10 | CNTN3, EMX2, HECW2, HEY2, KDR, MFAP5, MSX1, NKX2-3, NOTCH4, PRDM16 |
| Characteristic . | Number of genes . | Gene names . |
|---|---|---|
| Knockout mouse has a vascular phenotype* | 13 | COL4A1, COL4A2, CUBN, CYSLTR1, EMX2, FGL2, HEY2, KDR, MSX1, NKX2-3, NOTCH4, SEMA3C, SOX17 |
| Previously associated with cardiovascular disease or risk factors in humans† | 7 | ARL15, CNTN3, COL4A1, GRB14, MFAP5, NPR3, TOX2 |
| Coding for cell surface protein | 22 | A2M, ACE2, ADRB1, CNTN3, CYSLTR1, FAP, FAT1, FOLH1, KDR, NOTCH4, NPR3, NRCAM, PTPRR, SLC2A1, SLC2A3, SYTL2, XG, FLRT3, MPP7, NOS1, TMEM200A, TMEM200C |
| Coding for secreted protein | 14 | CCDC3, COL4A1, COL4A2, FAM19A5, FGL2, FREM1, LAMA2, MFAP5, ODAM, SEMA3C, SEMA3G, TFPI2, OLFML3, PAPLN |
| Coding for intracellular protein | 27 | AFF3, APO, CUBN, EMX2, FAM176A, GALNTL4, GLIPR2, GRB14, HECW2, HEY2, KLHL6, LMCD1, MAP9, MSX1, NAV1, NKX2-3, PDE4D, PRDM16, PSMAL, RGC-32, RYR3, SOX17, TOX2, CMBL, MGST1, SCARA3, SNTB2 |
| Coding for TF | 9 | AFF3, EMX2, HEY2, MSX1, NKX2-3, PRDM16, SOX17, TOX2, NR3C2 |
| Documented expression in aECs and/or vECs | 16 | APO, CCDC3, COL4A1, COL4A2, CYSLTR1, GLIPR2, HEY2, KDR, MFAP5, MSX1, NKX2-3, NOTCH4, RGC-32, SEMA3G, SOX17, NR3C2 |
| Previously associated with arteriovenous specification | 4 | HEY2, KDR, NOTCH4, S0X17 |
| Previously linked with the Notch pathway† | 10 | CNTN3, EMX2, HECW2, HEY2, KDR, MFAP5, MSX1, NKX2-3, NOTCH4, PRDM16 |