In vitro cytokine production by CAR T cells following 24-hour coculture with various target lines
| . | IFN-γ (pg/mL) . | TNF-α (pg/mL) . | IL-2 (pg/mL) . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LCL-OKT3 . | LCL . | K562 . | KG1a . | LCL-OKT3 . | LCL . | K562 . | KG1a . | LCL-OKT3 . | LCL . | K562 . | KG1a . | |
| Mock | 3749.2 | 324.7 | 168.5 | 86.0 | 1826.3 | 57.5 | 45.5 | 45.3 | 806.0 | 134.3 | 134.3 | 134.7 |
| CD19R | 4568.5 | 3850.5 | 116.5 | 129.7 | 1716.3 | 1107.3 | 44.3 | 65.8 | 327.3 | 240.0 | 126.7 | 140.5 |
| 26292 | 3464.8 | 1994.2 | 870.3 | 1978.3 | 1003.0 | 443.3 | 115.8 | 635.8 | 184.0 | 115.7 | 96.0 | 134.3 |
| 32716 | 1860.0 | 654.0 | 106.3 | 2031.2 | 666.2 | 242.2 | 48.5 | 800.2 | 198.3 | 137 | 120.3 | 317.7 |
| . | IFN-γ (pg/mL) . | TNF-α (pg/mL) . | IL-2 (pg/mL) . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LCL-OKT3 . | LCL . | K562 . | KG1a . | LCL-OKT3 . | LCL . | K562 . | KG1a . | LCL-OKT3 . | LCL . | K562 . | KG1a . | |
| Mock | 3749.2 | 324.7 | 168.5 | 86.0 | 1826.3 | 57.5 | 45.5 | 45.3 | 806.0 | 134.3 | 134.3 | 134.7 |
| CD19R | 4568.5 | 3850.5 | 116.5 | 129.7 | 1716.3 | 1107.3 | 44.3 | 65.8 | 327.3 | 240.0 | 126.7 | 140.5 |
| 26292 | 3464.8 | 1994.2 | 870.3 | 1978.3 | 1003.0 | 443.3 | 115.8 | 635.8 | 184.0 | 115.7 | 96.0 | 134.3 |
| 32716 | 1860.0 | 654.0 | 106.3 | 2031.2 | 666.2 | 242.2 | 48.5 | 800.2 | 198.3 | 137 | 120.3 | 317.7 |