Cox regression hazard ratios of event-free survivorship for rs3824662 (10p14) genotype
| . | Event-free survival . | Relapse . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | Unadjusted . | TEL-AML adjusted . | MRD adjusted . | . | ||||||||
| Genotype . | HR . | 95% CI . | P value . | HR . | 95% CI . | P value . | HR . | 95% CI . | P value . | HR . | 95% CI . | P value . |
| GG | 1.0 (ref) | — | — | 1.0 (ref) | — | — | 1.0 (ref) | — | — | 1.0 (ref) | — | — |
| TG | 1.40 | (1.10-1.77) | .005 | 1.45 | (1.14-1.86) | .003 | 1.23 | (0.96-1.58) | .10 | 1.29 | (0.98-1.70) | .06 |
| TT | 2.84 | (2.02-3.99) | 1.9 × 10−9 | 3.16 | (2.18-4.59) | 1.4 × 10−9 | 2.18 | (1.52-3.13) | 1.4 × 10−3 | 2.0 | (1.71-3.66) | 2.3 × 10−6 |
| . | Event-free survival . | Relapse . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | Unadjusted . | TEL-AML adjusted . | MRD adjusted . | . | ||||||||
| Genotype . | HR . | 95% CI . | P value . | HR . | 95% CI . | P value . | HR . | 95% CI . | P value . | HR . | 95% CI . | P value . |
| GG | 1.0 (ref) | — | — | 1.0 (ref) | — | — | 1.0 (ref) | — | — | 1.0 (ref) | — | — |
| TG | 1.40 | (1.10-1.77) | .005 | 1.45 | (1.14-1.86) | .003 | 1.23 | (0.96-1.58) | .10 | 1.29 | (0.98-1.70) | .06 |
| TT | 2.84 | (2.02-3.99) | 1.9 × 10−9 | 3.16 | (2.18-4.59) | 1.4 × 10−9 | 2.18 | (1.52-3.13) | 1.4 × 10−3 | 2.0 | (1.71-3.66) | 2.3 × 10−6 |
CI, confidence interval; HR, hazard ratios; MRD, mimimal residual disease; (ref), reference group Web site links as follows:
The R suite can be found at http://www.r-project.org.
Detailed information on the tag SNP panel can be found at http://www.illumina.com.
The dbSNP can be found at http://www.ncbi.nlm.nih.gov.
HapMap can be found at http://www.hapmap.org.
1000genomes can be found at http://www.1000genomes.org.
KBioscience can be found at http://kbioscience.co.uk.
SNAP can be found at http://www.broadinstitute.org/mpg/snap.
IMPUTE can be found at https://mathgen.stats.ox.ac.uk.
EIGENSTRAT can be found at http://genetics.med.harvard.edu/reich/Reich_Lab/Software.html.
Wellcome Trust Case Control Consortium can be found at www.wtccc.org.uk.
Mendelian Inheritance In Man can be found at http://www.ncbi.nlm.nih.gov/omim.
1958 Birth Cohort can be found at http://www.cls.ioe.ac.uk/page.aspx?&sitesectionid=724&sitesectiontitle=Welcome+to+the+1958+National+Child+Development+Study.
Medical Research Council ALL 97 (Protocol 97PRT/14) can be found at http://www.thelancet.com/protocol-reviews/97PRT-14.
United Kingdom Childhood Cancer Study can be found at http://www.ukccs.org.
UCSC genome browser can be found at http://genome.ucsc.edu.
Surveillance, Epidemiology and End Results can be found at seer.cancer.gov/.
RegulomeDB can be found at http://regulome.stanford.edu/.
HaploREG can be found at http://www.broadinstitute.org/mammals/haploreg/haploreg.php.