Table 1

Relationship between rs10828317 and rs3824662 genotype and age at diagnosis and sex

SNPUK GWASGerman GWASReplication
TTTCCCTTTCCCTTTCCC
rs10828317 (10p12.2) (PIP4K2A)          
 ALL          
  Median age 4 4 5 4 4 4 4 4 4 
  Mean age (SD) 5.2 (3.5) 5.5 (3.6) 5.9 (4.0) 5.9 (4.1) 5.6 (4.3) 6.0 (4.4) 5.8 (4.3) 5.9 (4.3) 5.5 (4.0) 
  F:M 0.41/0.59 0.46/0.54 0.53/0.47 0.46/0.54 0.49/0.51 0.39/0.61 0.46/0.54 0.43/0.57 0.58/0.42 
 Hyperdiploid          
  Median age 4 4 3 3 3 3 4 4 4 
  Mean age (SD) 4.8 (3.1) 5.0 (3.2) 4.4 (3.6) 4.7 (3.7) 4.7 (3.2) 4.6 (2.5) 5.1 (3.9) 4.8 (3.6) 6.0 (4.9) 
  F:M 0.38/0.62 0.45/0.56 0.63/0.37 0.43/0.57 0.49/0.51 0.36/0.64 0.52/0.4 0.36/0.64 0.58/0.42 
 TEL-AML          
  Median age 4.5 4 5 4 4 7 4 4 4 
  Mean age (SD) 4.9 (2.7) 4.6 (2.1) 4.6 (1.6) 4.4 (2.7) 4.6 (2.7) 6.4 (3.1) 4.6 (2.9) 4.9 (2.9) 4.7 (2.6) 
  F:M 0.40/0.60 0.47/0.53 0.18/0.82 0.50/0.50 0.31/0.69 0.56/0.44 0.46/0.54 0.46/0.54 0.56/0.44 
 Non–HD/TEL-AML          
  Median 4 5 6 6 4 4.5 6 6 3 
  Mean age (SD) 5.7 (4.0) 6.2 (4.1) 6.8 (4.4) 6.7 (4.3) 5.9 (4.8) 6.7 (5.0) 6.9 (4.8) 7.1 (4.8) 6.1 (5.5) 
  F:M 0.43/0.57
 		0.46/0.54
 		0.59/0.41
 		0.46/0.54
 		0.50/0.50
 		0.32/0.68
 		0.46/0.54
 		0.46/0.54
 		0.62/0.38
 
 TT
 		TG
 		GG
 		TT
 		TG
 		GG
 		TT
 		TG
 		GG
 
rs3824662 (10p14) (GATA3)          
 ALL          
  Median age 5 4.5 4* 7 4 4† 6 4 4‡ 
  Mean age (SD) 6.1 (3.8) 5.8 (3.9) 5.1 (3.3) 7.0 (4.3) 6.1(4.3) 5.5 (4.2) 6.8 (4.5) 6.0 (4.4) 5.6 (4.1) 
  F:M 0.48/0.52 0.42/0.58 0.45/0.55 0.51/0.49 0.46/0.54 0.46/0.54 0.39/0.61 0.45/0.55 0.10/0.90 
 Hyperdiploid          
  Median age 5 3 4 3 3 4§ 6 3 4 
  Mean age (SD) 6.0 (3.6) 4.6 (3.3) 4.8 (3.0) 2.8 (1.2) 4.1 (3.0) 5.1 (3.7) 6.5 (4.7) 4.6 (3.8) 5.1 (3.8) 
  F:M 0.43/0.57 0.45/0.55 0.42/0.58 0.44/0.56 0.52/0.48 0.41/0.59 0.46/0.54 0.49/0.51 0.37/0.63 
 TEL-AML          
  Median age 6 5 4 3 4 4 4 4 4 
  Mean age (SD) 6.0 (2.8) 5.2 (2.3) 4.5 (2.3) 3.7 (2.2) 4.8 (2.5) 4.9 (3.0) 4.1 (2.0) 4.7 (2.5) 4.8 (3.1) 
  F:M 0.0/1.0 0.33/0.67 0.44/0.56 0.50/0.50 0.40/0.60 0.44/0.56 0.21/0.79 0.43/0.57 0.30/0.70 
 Non–HD/TEL-AML          
  Median age 5.5 6 4 8 7 4|| 7.5 7 5 
  Mean age (SD) 6.2 (4.2) 6.8 (4.4) 5.6 (3.9) 8.0 (4.6) 7.2 (4.5) 5.7 (4.4) 8.3 (5.0) 7.4 (5.0) 6.4 (4.6) 
  F:M 0.56/0.44 0.44/0.56 0.48/0.52 0.48/0.52 0.44/0.56 0.30/0.70 0.31/0.69 0.46/0.54 0.27/0.73 
SNPUK GWASGerman GWASReplication
TTTCCCTTTCCCTTTCCC
rs10828317 (10p12.2) (PIP4K2A)          
 ALL          
  Median age 4 4 5 4 4 4 4 4 4 
  Mean age (SD) 5.2 (3.5) 5.5 (3.6) 5.9 (4.0) 5.9 (4.1) 5.6 (4.3) 6.0 (4.4) 5.8 (4.3) 5.9 (4.3) 5.5 (4.0) 
  F:M 0.41/0.59 0.46/0.54 0.53/0.47 0.46/0.54 0.49/0.51 0.39/0.61 0.46/0.54 0.43/0.57 0.58/0.42 
 Hyperdiploid          
  Median age 4 4 3 3 3 3 4 4 4 
  Mean age (SD) 4.8 (3.1) 5.0 (3.2) 4.4 (3.6) 4.7 (3.7) 4.7 (3.2) 4.6 (2.5) 5.1 (3.9) 4.8 (3.6) 6.0 (4.9) 
  F:M 0.38/0.62 0.45/0.56 0.63/0.37 0.43/0.57 0.49/0.51 0.36/0.64 0.52/0.4 0.36/0.64 0.58/0.42 
 TEL-AML          
  Median age 4.5 4 5 4 4 7 4 4 4 
  Mean age (SD) 4.9 (2.7) 4.6 (2.1) 4.6 (1.6) 4.4 (2.7) 4.6 (2.7) 6.4 (3.1) 4.6 (2.9) 4.9 (2.9) 4.7 (2.6) 
  F:M 0.40/0.60 0.47/0.53 0.18/0.82 0.50/0.50 0.31/0.69 0.56/0.44 0.46/0.54 0.46/0.54 0.56/0.44 
 Non–HD/TEL-AML          
  Median 4 5 6 6 4 4.5 6 6 3 
  Mean age (SD) 5.7 (4.0) 6.2 (4.1) 6.8 (4.4) 6.7 (4.3) 5.9 (4.8) 6.7 (5.0) 6.9 (4.8) 7.1 (4.8) 6.1 (5.5) 
  F:M 0.43/0.57
 		0.46/0.54
 		0.59/0.41
 		0.46/0.54
 		0.50/0.50
 		0.32/0.68
 		0.46/0.54
 		0.46/0.54
 		0.62/0.38
 
 TT
 		TG
 		GG
 		TT
 		TG
 		GG
 		TT
 		TG
 		GG
 
rs3824662 (10p14) (GATA3)          
 ALL          
  Median age 5 4.5 4* 7 4 4† 6 4 4‡ 
  Mean age (SD) 6.1 (3.8) 5.8 (3.9) 5.1 (3.3) 7.0 (4.3) 6.1(4.3) 5.5 (4.2) 6.8 (4.5) 6.0 (4.4) 5.6 (4.1) 
  F:M 0.48/0.52 0.42/0.58 0.45/0.55 0.51/0.49 0.46/0.54 0.46/0.54 0.39/0.61 0.45/0.55 0.10/0.90 
 Hyperdiploid          
  Median age 5 3 4 3 3 4§ 6 3 4 
  Mean age (SD) 6.0 (3.6) 4.6 (3.3) 4.8 (3.0) 2.8 (1.2) 4.1 (3.0) 5.1 (3.7) 6.5 (4.7) 4.6 (3.8) 5.1 (3.8) 
  F:M 0.43/0.57 0.45/0.55 0.42/0.58 0.44/0.56 0.52/0.48 0.41/0.59 0.46/0.54 0.49/0.51 0.37/0.63 
 TEL-AML          
  Median age 6 5 4 3 4 4 4 4 4 
  Mean age (SD) 6.0 (2.8) 5.2 (2.3) 4.5 (2.3) 3.7 (2.2) 4.8 (2.5) 4.9 (3.0) 4.1 (2.0) 4.7 (2.5) 4.8 (3.1) 
  F:M 0.0/1.0 0.33/0.67 0.44/0.56 0.50/0.50 0.40/0.60 0.44/0.56 0.21/0.79 0.43/0.57 0.30/0.70 
 Non–HD/TEL-AML          
  Median age 5.5 6 4 8 7 4|| 7.5 7 5 
  Mean age (SD) 6.2 (4.2) 6.8 (4.4) 5.6 (3.9) 8.0 (4.6) 7.2 (4.5) 5.7 (4.4) 8.3 (5.0) 7.4 (5.0) 6.4 (4.6) 
  F:M 0.56/0.44 0.44/0.56 0.48/0.52 0.48/0.52 0.44/0.56 0.30/0.70 0.31/0.69 0.46/0.54 0.27/0.73 

F, female; HD/TEL-AML, hyperdiploid TEL-AML; M, male; SD, standard deviation.

*

P = .04.

†

P = .002.

‡

P = .003.

§

P = .03.

||

P = .0003.

P = .004.

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