Morphological, immunological, and genetic features differentiating BL, BCLU, and DLBCL with MYC rearrangements
| Feature . | BL . | BCLU . | DLBCL . |
|---|---|---|---|
| Architecture | Cohesive | Often cohesive | Variable |
| Starry sky pattern | As a rule | Very often | Sometimes |
| Cell size | Medium | Medium/large | Large |
| Chromatin distribution | Coarse | Variable | Fine |
| Proliferation (Ki67) | >95% | Variable, often <95% | Variable, more often <95% |
| CD10 | Almost always | Frequent | 30% |
| BCL2 protein expression | Negative/weak | Variable | Variable |
| MYC translocation | >90% (IGH) | 35%-50% (IGL and non-IG) | 5%-14% (IGL und non-IG) |
| BCL2/BCL6 translocation in addition to MYC | No | Frequent | 50%-70% |
| Complex karyotype | No | Yes | Yes |
| Feature . | BL . | BCLU . | DLBCL . |
|---|---|---|---|
| Architecture | Cohesive | Often cohesive | Variable |
| Starry sky pattern | As a rule | Very often | Sometimes |
| Cell size | Medium | Medium/large | Large |
| Chromatin distribution | Coarse | Variable | Fine |
| Proliferation (Ki67) | >95% | Variable, often <95% | Variable, more often <95% |
| CD10 | Almost always | Frequent | 30% |
| BCL2 protein expression | Negative/weak | Variable | Variable |
| MYC translocation | >90% (IGH) | 35%-50% (IGL and non-IG) | 5%-14% (IGL und non-IG) |
| BCL2/BCL6 translocation in addition to MYC | No | Frequent | 50%-70% |
| Complex karyotype | No | Yes | Yes |