MYC activation and cooperating mechanisms in aggressive B-cell lymphomas
| Lymphoma . | Normal cell counterpart . | MYC inhibitory physiological mechanism . | MYC oncogenic activation . | MYC cooperating mechanism* . |
|---|---|---|---|---|
| BL | DZ GC cell | BCL6 | MYC translocation | TCF3/ID3/CCND3 mutations |
| GCB-DLBCL | LZ GC cell | BCL6 | MYC translocation/? | BCL2 translocation |
| ABC-DLBCL | LZ GC cell | BCL6 | BCR/MYD88 activation | BCL2 overexpression (18q amplifications) |
| PBL | Plasmablast | BLIMP1 | MYC translocation | ER stress response? |
| ALK-positive large B-cell lymphoma | Plasmablast | BLIMP1 | ALK-STAT3 activation? | ER stress response? |
| Lymphoma . | Normal cell counterpart . | MYC inhibitory physiological mechanism . | MYC oncogenic activation . | MYC cooperating mechanism* . |
|---|---|---|---|---|
| BL | DZ GC cell | BCL6 | MYC translocation | TCF3/ID3/CCND3 mutations |
| GCB-DLBCL | LZ GC cell | BCL6 | MYC translocation/? | BCL2 translocation |
| ABC-DLBCL | LZ GC cell | BCL6 | BCR/MYD88 activation | BCL2 overexpression (18q amplifications) |
| PBL | Plasmablast | BLIMP1 | MYC translocation | ER stress response? |
| ALK-positive large B-cell lymphoma | Plasmablast | BLIMP1 | ALK-STAT3 activation? | ER stress response? |
DZ indicates dark zone; and LZ, light zone.
TP53 and MYC mutations present in all types of lymphomas may help the tumor cells to escape the apoptotic effect of MYC.20,38