Clinical and hematologic data of neonates recruited to the OIDSC Study
| . | Number of neonates with DS . | |||
|---|---|---|---|---|
| TAM (n = 17) . | DS without TAM (n = 183) . | P . | Normal range* . | |
| Clinical characteristics | ||||
| Gender | 9:8 | 96:87 | 1.0000 | — |
| M:F | (1·1:1) | (1.1:1) | ||
| Gestation at birth, wk (range) | 37·0 (34·4-39·6) | 38·0 (30.9-42.6) | .1717 | — |
| Preterm (<37 wk) | 5 (29.4%) | 39 (21.3%) | .5408 | — |
| Small for gestational age† | 2 (11.8%) | 10 (5.5%) | .2749 | — |
| Hepato(spleno)megaly | 7 (41.2%) | 6 (3.3%) | <.0001 | — |
| Jaundice | 13 (76.4%) | 78 (42.9%) | .0098 | — |
| Rash | 3 (17.6%) | 1 (0.6%) | .0020 | — |
| Pleural/pericardial effusion/ ascites | 1 (5.9%) | 3 (1.6%) | .3010 | — |
| Congenital heart disease | 8 (47.1%) | 90 (49.2%) | 1.0000 | — |
| Other congenital anomalies‡ | 2 (11.8%) | 20 (10.9%) | 1.0000 | — |
| Hematologic characteristics | ||||
| Median Hb g/dL (range) | 18.4 (11.7-22.2) | 20·5 (7.7-28.0) | .0011 | 16.6 (12.7-20.3) |
| Median hematocrit (range) | 0·562 (0.357-0.647) | 0.599 (0.243-0.822) | .0122 | 0.503 (0.408-0·610) |
| Anemia | 1 (5.9%) | 3 (1.6%) | .3010 | Hct >0.400 |
| Median MCV (fL) | 108 (93.3-133) | 108 (88.7-123.8) | .2104 | 103·5 (89.6-117.7) |
| Nucleated red cells/100 WBC | 8 (1-122) | 5 (0-186) | .0187 | 1 (0-29) |
| Median platelets ×109/L§ | 117 (36-446) | 148.5 (9-432) | .9014 | 253 (150-388) |
| MPV (fL)§ | 9·75 (7.4-13.5) | 10.6 (7.3-12.8) | .6448 | 10.4 (8.1-12.5) |
| Thrombocytopenia | 10 (54.6%) | 91 (50.6%) | .6152 | Platelets <150 × 109/L |
| WBC ×109/L | 25.8 (19.7-73.2) | 14.1 (4.6-51.72) | <.0001 | 11.6 (4.9-26.7) |
| Blasts (%) | 35 (15-77) | 4 (0-15) | <.0001 | 0 (0-4) |
| Neutrophils ×109/L | 13·80 (7.0-31.0) | 9.57 (0.12-38.1) | .0372 | 6.2 (1.36-20.1) |
| Metamyelocytes ×109/L | 0.79 (0-5.66) | 0.35 (0-5.18) | .2986 | N/A |
| Myelocytes ×109/L | 0.25 (0-3.96) | 0 (0-1.94) | <.0001 | N/A |
| Monocytes ×109/L | 1.41 (0.3-6.7) | 1.11 (0.08-6.96) | .3082 | 0.78 (0-2.67) |
| Basophils ×109/L | 0·37 (0-2.0) | 0.17 (0-2·3) | <.0001 | 0 (0-0.15) |
| Eosinophils ×109/L | 0·24 (0-1.12) | 0.22 (0-1·18) | .9543 | 0·20 (0-1.87) |
| Lymphocytes ×109/L | 6.0 (0.23-19.2) | 2.94 (0.4-8.5) | <.0001 | 3.8 (0.86-9.7) |
| . | Number of neonates with DS . | |||
|---|---|---|---|---|
| TAM (n = 17) . | DS without TAM (n = 183) . | P . | Normal range* . | |
| Clinical characteristics | ||||
| Gender | 9:8 | 96:87 | 1.0000 | — |
| M:F | (1·1:1) | (1.1:1) | ||
| Gestation at birth, wk (range) | 37·0 (34·4-39·6) | 38·0 (30.9-42.6) | .1717 | — |
| Preterm (<37 wk) | 5 (29.4%) | 39 (21.3%) | .5408 | — |
| Small for gestational age† | 2 (11.8%) | 10 (5.5%) | .2749 | — |
| Hepato(spleno)megaly | 7 (41.2%) | 6 (3.3%) | <.0001 | — |
| Jaundice | 13 (76.4%) | 78 (42.9%) | .0098 | — |
| Rash | 3 (17.6%) | 1 (0.6%) | .0020 | — |
| Pleural/pericardial effusion/ ascites | 1 (5.9%) | 3 (1.6%) | .3010 | — |
| Congenital heart disease | 8 (47.1%) | 90 (49.2%) | 1.0000 | — |
| Other congenital anomalies‡ | 2 (11.8%) | 20 (10.9%) | 1.0000 | — |
| Hematologic characteristics | ||||
| Median Hb g/dL (range) | 18.4 (11.7-22.2) | 20·5 (7.7-28.0) | .0011 | 16.6 (12.7-20.3) |
| Median hematocrit (range) | 0·562 (0.357-0.647) | 0.599 (0.243-0.822) | .0122 | 0.503 (0.408-0·610) |
| Anemia | 1 (5.9%) | 3 (1.6%) | .3010 | Hct >0.400 |
| Median MCV (fL) | 108 (93.3-133) | 108 (88.7-123.8) | .2104 | 103·5 (89.6-117.7) |
| Nucleated red cells/100 WBC | 8 (1-122) | 5 (0-186) | .0187 | 1 (0-29) |
| Median platelets ×109/L§ | 117 (36-446) | 148.5 (9-432) | .9014 | 253 (150-388) |
| MPV (fL)§ | 9·75 (7.4-13.5) | 10.6 (7.3-12.8) | .6448 | 10.4 (8.1-12.5) |
| Thrombocytopenia | 10 (54.6%) | 91 (50.6%) | .6152 | Platelets <150 × 109/L |
| WBC ×109/L | 25.8 (19.7-73.2) | 14.1 (4.6-51.72) | <.0001 | 11.6 (4.9-26.7) |
| Blasts (%) | 35 (15-77) | 4 (0-15) | <.0001 | 0 (0-4) |
| Neutrophils ×109/L | 13·80 (7.0-31.0) | 9.57 (0.12-38.1) | .0372 | 6.2 (1.36-20.1) |
| Metamyelocytes ×109/L | 0.79 (0-5.66) | 0.35 (0-5.18) | .2986 | N/A |
| Myelocytes ×109/L | 0.25 (0-3.96) | 0 (0-1.94) | <.0001 | N/A |
| Monocytes ×109/L | 1.41 (0.3-6.7) | 1.11 (0.08-6.96) | .3082 | 0.78 (0-2.67) |
| Basophils ×109/L | 0·37 (0-2.0) | 0.17 (0-2·3) | <.0001 | 0 (0-0.15) |
| Eosinophils ×109/L | 0·24 (0-1.12) | 0.22 (0-1·18) | .9543 | 0·20 (0-1.87) |
| Lymphocytes ×109/L | 6.0 (0.23-19.2) | 2.94 (0.4-8.5) | <.0001 | 3.8 (0.86-9.7) |
N/A, not applicable; WBC, white blood cells.
Derived from anonymized data from 80 normal healthy term (37-42 wk) and 43 preterm (31-36 wk) neonates (see supplemental Methods).
Defined as birthweight <10th percentile for gestational age.
Duodenal atresia, esophageal atresia, tracheo-esophageal fistula, imperforate anus, Hirschsprung's, renal anomalies
Platelet count not available in 3 neonates due to platelet clumping and automated MPV measurable for 6 of 17 neonates with TAM, 59 of 183 DS neonates without TAM, and 122 neonates without DS.