Risks of TRM, relapse, treatment failure, and overall mortality
| Variable . | Hazard ratio (95% confidence interval) . | P . |
|---|---|---|
| TRM* | ||
| Double UCB vs single UCB | 0.91 (0.65-1.27) | .56 |
| Relapse | ||
| Double UCB vs single UCB | 0.93 (0.55-1.56) | .78 |
| Disease status at transplantation | ||
| Second/third vs first CR | 1.33 (1.01-1.76) | .05 |
| Relapse vs first CR | 3.56 (2.69-4.72) | < .0001 |
| Age, y | ||
| 21-40 vs 16-20 | 2.73 (1.51-4.92) | .001 |
| > 40 vs 16-20 | 2.59 (1.32-5.12) | .006 |
| Conditioning regimen | ||
| Non-TBI MAC vs TBI MAC | 2.69 (1.68-4.32) | < .0001 |
| Non-TBI RIC vs TBI MAC | 1.79 (1.06-3.03) | .03 |
| TBI RIC vs TBI MAC | 3.14 (2.13-4.63) | < .0001 |
| Treatment failure (inverse of LFS) | ||
| Double UCB vs single UCB | 0.97 (0.77-1.22) | .80 |
| Disease status at transplantation | ||
| Second/third vs first CR | 1.27 (1.04-1.55) | .02 |
| Relapse vs first CR | 2.22 (1.78-2.76) | < .0001 |
| Overall mortality | ||
| Double UCB vs single UCB | 0.93 (0.65-1.33) | .67 |
| Disease status at transplantation | ||
| Second/third vs first CR | 1.34 (1.05-1.70) | .02 |
| Relapse vs first CR | 2.28 (1.83-2.86) | < .0001 |
| Variable . | Hazard ratio (95% confidence interval) . | P . |
|---|---|---|
| TRM* | ||
| Double UCB vs single UCB | 0.91 (0.65-1.27) | .56 |
| Relapse | ||
| Double UCB vs single UCB | 0.93 (0.55-1.56) | .78 |
| Disease status at transplantation | ||
| Second/third vs first CR | 1.33 (1.01-1.76) | .05 |
| Relapse vs first CR | 3.56 (2.69-4.72) | < .0001 |
| Age, y | ||
| 21-40 vs 16-20 | 2.73 (1.51-4.92) | .001 |
| > 40 vs 16-20 | 2.59 (1.32-5.12) | .006 |
| Conditioning regimen | ||
| Non-TBI MAC vs TBI MAC | 2.69 (1.68-4.32) | < .0001 |
| Non-TBI RIC vs TBI MAC | 1.79 (1.06-3.03) | .03 |
| TBI RIC vs TBI MAC | 3.14 (2.13-4.63) | < .0001 |
| Treatment failure (inverse of LFS) | ||
| Double UCB vs single UCB | 0.97 (0.77-1.22) | .80 |
| Disease status at transplantation | ||
| Second/third vs first CR | 1.27 (1.04-1.55) | .02 |
| Relapse vs first CR | 2.22 (1.78-2.76) | < .0001 |
| Overall mortality | ||
| Double UCB vs single UCB | 0.93 (0.65-1.33) | .67 |
| Disease status at transplantation | ||
| Second/third vs first CR | 1.34 (1.05-1.70) | .02 |
| Relapse vs first CR | 2.28 (1.83-2.86) | < .0001 |
CR indicates complete remission; LFS, leukemia-free survival; MAC, myleoablative conditioning; RIC, reduced-intensity conditioning; TBI, total body irradiation; TRM, transplantation-related mortality; and UCB, umbilical cord blood.
Stratified for transplantation-conditioning regimen and GVHD prophylaxis.