SNPs associated with log CD34+ after adjustment for age and sex
| Candidate gene(s) . | Loci . | SNP . | Position, bp . | Location relative to gene . | MAF . | A1-A2 . | Estimated regression coefficient (SE)* . | P . |
|---|---|---|---|---|---|---|---|---|
| OR4C12 | 11p11.1 | rs2183383 | 50194788 | Downstream | 0.20 | C-T | −0.22 (0.04) | 6.67 × 10−7 |
| ENO1, RERE | 1p36 | rs11121242 | 8828888 | Intergenic | 0.48 | G-A | −0.19 (0.04) | 8.81 × 10−7 |
| rs6577536 | 8832697 | Intergenic | 0.47 | G-A | −0.18 (0.04) | 9.78 × 10−7 | ||
| rs11121245 | 8838811 | Downstream | 0.49 | C-T | −0.17 (0.04) | 3.10 × 10−6 | ||
| rs11590606 | 8840256 | Downstream | 0.49 | T-C | −0.17 (0.04) | 3.17 × 10−6 | ||
| rs10864368 | 8840900 | Downsteram | 0.49 | C-T | −0.17 (0.04) | 3.18 × 10−6 | ||
| DGKB | 7p21 | rs976760 | 14240178 | Intronic | 0.26 | C-T | 0.25 (0.05) | 2.86 × 10−6 |
| DSC3 | 18q12 | rs1943535 | 26620710 | Intergenic | −0.25 | G-T | −0.25 (0.05) | 4.61 × 10−6 |
| rs2591120 | 26621355 | Intergenic | −0.25 | A-T | −0.25 (0.05) | 4.62 × 10−6 | ||
| rs2591119 | 26621746 | Intergenic | −0.25 | A-G | −0.25 (0.05) | 4.65 × 10−6 | ||
| rs2591118 | 26621891 | Intergenic | −0.25 | T-C | −0.25 (0.05) | 4.65 × 10−6 | ||
| rs2733151 | 26624082 | Intergenic | −0.23 | T-A | −0.23 (0.05) | 4.89 × 10−6 | ||
| rs2733150 | 26624049 | Intergenic | −0.23 | C-G | −0.23 (0.05) | 4.90 × 10−6 | ||
| rs2591117 | 26624221 | Intergenic | −0.23 | A-T | −0.23 (0.05) | 4.93 × 10−6 | ||
| rs2591116 | 26624582 | Intergenic | −0.23 | A-T | −0.23 (0.05) | 4.94 × 10−6 | ||
| rs2105759 | 26626223 | Intergenic | −0.23 | A-T | −0.23 (0.05) | 4.99 × 10−6 | ||
| rs2733152 | 26627615 | Intergenic | −0.23 | A-G | −0.23 (0.05) | 4.99 × 10−6 |
| Candidate gene(s) . | Loci . | SNP . | Position, bp . | Location relative to gene . | MAF . | A1-A2 . | Estimated regression coefficient (SE)* . | P . |
|---|---|---|---|---|---|---|---|---|
| OR4C12 | 11p11.1 | rs2183383 | 50194788 | Downstream | 0.20 | C-T | −0.22 (0.04) | 6.67 × 10−7 |
| ENO1, RERE | 1p36 | rs11121242 | 8828888 | Intergenic | 0.48 | G-A | −0.19 (0.04) | 8.81 × 10−7 |
| rs6577536 | 8832697 | Intergenic | 0.47 | G-A | −0.18 (0.04) | 9.78 × 10−7 | ||
| rs11121245 | 8838811 | Downstream | 0.49 | C-T | −0.17 (0.04) | 3.10 × 10−6 | ||
| rs11590606 | 8840256 | Downstream | 0.49 | T-C | −0.17 (0.04) | 3.17 × 10−6 | ||
| rs10864368 | 8840900 | Downsteram | 0.49 | C-T | −0.17 (0.04) | 3.18 × 10−6 | ||
| DGKB | 7p21 | rs976760 | 14240178 | Intronic | 0.26 | C-T | 0.25 (0.05) | 2.86 × 10−6 |
| DSC3 | 18q12 | rs1943535 | 26620710 | Intergenic | −0.25 | G-T | −0.25 (0.05) | 4.61 × 10−6 |
| rs2591120 | 26621355 | Intergenic | −0.25 | A-T | −0.25 (0.05) | 4.62 × 10−6 | ||
| rs2591119 | 26621746 | Intergenic | −0.25 | A-G | −0.25 (0.05) | 4.65 × 10−6 | ||
| rs2591118 | 26621891 | Intergenic | −0.25 | T-C | −0.25 (0.05) | 4.65 × 10−6 | ||
| rs2733151 | 26624082 | Intergenic | −0.23 | T-A | −0.23 (0.05) | 4.89 × 10−6 | ||
| rs2733150 | 26624049 | Intergenic | −0.23 | C-G | −0.23 (0.05) | 4.90 × 10−6 | ||
| rs2591117 | 26624221 | Intergenic | −0.23 | A-T | −0.23 (0.05) | 4.93 × 10−6 | ||
| rs2591116 | 26624582 | Intergenic | −0.23 | A-T | −0.23 (0.05) | 4.94 × 10−6 | ||
| rs2105759 | 26626223 | Intergenic | −0.23 | A-T | −0.23 (0.05) | 4.99 × 10−6 | ||
| rs2733152 | 26627615 | Intergenic | −0.23 | A-G | −0.23 (0.05) | 4.99 × 10−6 |
MAF indicates minor allele frequency; A1, major allele; and A2, minor allele.
The regression coefficients shown can be used to estimate the magnitude of association between the SNP and CD34+ frequency. For example, the presence of the OR4C12 polymorphism is associated with an e(−0.22) = 0.80, or 20% lower CD34+ frequency. Therefore, for a subject with the median value of CD34+ frequency (ie, 0.076% or 7.6 × 10−4), the presence of this polymorphism would be associated with a 1.5 × 10−4 lower CD34+ frequency.