Warfarin binding interfaces on hVKORC1
| Warfarin binding interface . | Corresponding hVKORC1 residues . | Mutations associated with binding interface . |
|---|---|---|
| I | Leu22-Val29 | Ala26Thr, Ala26Pro, Leu27Val, His28Gln, Val29Leu |
| II | Ser52-Phe55 | Ser52Leu, Ser52Trp, Val54Leu, Asp36Gly, Asp36Tyr, Val45Ala, Ser56Phe, Arg58Gly Trp59Arg, Trp59Cys, Trp59Leu |
| III | Phe131-Thr137 | Leu128Arg, Ile123Asn, Tyr139His |
| Membrane embedded loop segment | Gly62-Ser79 | Val66Gly, Val66Met, Gly71Ala, Asn77Ser, Asn77Tyr |
| Warfarin binding interface . | Corresponding hVKORC1 residues . | Mutations associated with binding interface . |
|---|---|---|
| I | Leu22-Val29 | Ala26Thr, Ala26Pro, Leu27Val, His28Gln, Val29Leu |
| II | Ser52-Phe55 | Ser52Leu, Ser52Trp, Val54Leu, Asp36Gly, Asp36Tyr, Val45Ala, Ser56Phe, Arg58Gly Trp59Arg, Trp59Cys, Trp59Leu |
| III | Phe131-Thr137 | Leu128Arg, Ile123Asn, Tyr139His |
| Membrane embedded loop segment | Gly62-Ser79 | Val66Gly, Val66Met, Gly71Ala, Asn77Ser, Asn77Tyr |
The 3 predicted interfaces for warfarin binding in VKORC1 (called interface I, II, and III) are listed here along with the residues/reported mutations that are located close to each of these interfaces and the 5 mutations that are distant to the 3 interfaces.