Frequency of new prognostic features in subtypes of pediatric ALL
| Subgroup . | BCR-ABL1-like . | . | IKZF1-deleted . | CRLF2-high . | |||
|---|---|---|---|---|---|---|---|
| n . | % . | Subtype . | n . | % . | n . | % . | |
| Hyperdiploid | 0/130 | 0 | 32/208 | 15 | 25/130 | 19 | |
| ETV6-RUNX1 positive | 0/162 | 0 | 7/225 | 3 | 0/162 | 0 | |
| TCF3 rearranged | 0/19 | 0 | 1/19 | 5 | 0/19 | 0 | |
| MLL rearranged | 0/12 | 0 | 2/27 | 7 | 1/12 | 8 | |
| B-other* | 94/176 | 53 | BCR-ABL1-like† | 37/92 | 40 | 15/94 | 16 |
| Remaining B-other | 16/80 | 20 | 10/82 | 12 | |||
| BCR-ABL1 positive | 0/24 | 0 | 16/23 | 70 | 0/24 | 0 | |
| Unknown BCP-ALL‡ | 0/49 | 0 | 43/233 | 18 | 5/49 | 10 | |
| Total BCP-ALL | 94/572 | 16 | 154/907 | 17 | 56/572 | 10 | |
| T-ALL | 0/80 | 0 | 5/157 | 3 | 1/80 | 1 | |
| Subgroup . | BCR-ABL1-like . | . | IKZF1-deleted . | CRLF2-high . | |||
|---|---|---|---|---|---|---|---|
| n . | % . | Subtype . | n . | % . | n . | % . | |
| Hyperdiploid | 0/130 | 0 | 32/208 | 15 | 25/130 | 19 | |
| ETV6-RUNX1 positive | 0/162 | 0 | 7/225 | 3 | 0/162 | 0 | |
| TCF3 rearranged | 0/19 | 0 | 1/19 | 5 | 0/19 | 0 | |
| MLL rearranged | 0/12 | 0 | 2/27 | 7 | 1/12 | 8 | |
| B-other* | 94/176 | 53 | BCR-ABL1-like† | 37/92 | 40 | 15/94 | 16 |
| Remaining B-other | 16/80 | 20 | 10/82 | 12 | |||
| BCR-ABL1 positive | 0/24 | 0 | 16/23 | 70 | 0/24 | 0 | |
| Unknown BCP-ALL‡ | 0/49 | 0 | 43/233 | 18 | 5/49 | 10 | |
| Total BCP-ALL | 94/572 | 16 | 154/907 | 17 | 56/572 | 10 | |
| T-ALL | 0/80 | 0 | 5/157 | 3 | 1/80 | 1 | |
B-other cases are negative for hyperdiploidy, ETV6-RUNX1, TCF3 rearrangement, MLL rearrangement, and BCR-ABL1 translocation.
BCR-ABL1-like cases are negatively tested for BCR-ABL1 translocation; BCR-ABL1–positive cases are allocated to the BCR-ABL1–positive group.
Unknown BCP-ALL cases are negative for BCR-ABL1 translocation, MLL rearrangement, and BCR-ABL1-like signature, but other cytogenetic lesions were not determined.