Significant regions affected by DNA gains and losses in the RS genome, as estimated using the GISTIC algorithm
| Lesion . | Cytoband . | Frequency, % . | Start* . | Size, Kb* . | q value . | Residual q value . | Candidate genes . |
|---|---|---|---|---|---|---|---|
| Gains | |||||||
| 13q31.3 | 12 | 9.02E+07 | 2.40E+06 | 0.13392 | 0.13392 | MIR17HG | |
| Losses | |||||||
| 13q14.2-q14.3 | 29 | 5.07E+07 | 6.16E+05 | 7.17E-15 | 9.14E-15 | DLEU2/MIR15A/MIR16 | |
| 9p21.3 | 22 | 2.16E+07 | 8.94E+05 | 3.13E-05 | 3.13E-05 | CDKN2A | |
| 14q24.2-q32.33 | 16 | 7.11E+07 | 3.53E+07 | 7.71E-05 | 0.0013523 | TRAF3 | |
| 7q32.3-q36.2 | 12 | 1.31E+08 | 2.24E+07 | 0.0025523 | 0.0025523 | ||
| 1q42.12-q43 | 14 | 2.26E+08 | 1.11E+07 | 0.014836 | 0.014836 | ||
| 15q14-q15.1 | 9 | 3.89E+07 | 3.70E+06 | 0.026537 | 0.041218 | MGA | |
| 4q34.1-q35.2 | 10 | 1.74E+08 | 1.67E+07 | 0.11945 | 0.11556 | ||
| 9q33.3 | 16 | 1.28E+08 | 6.22E+05 | 0.12385 | 0.12385 | ||
| 15q11.2-q14 | 9 | 2.24E+07 | 1.24E+07 | 0.057148 | 0.12387 | ||
| 1p36.33-p34.2 | 14 | 1.00E+00 | 4.12E+07 | 0.13304 | 0.13304 | TNFRSF14 | |
| 11q21-q23.3 | 12 | 9.57E+07 | 2.16E+07 | 0.13304 | 0.13304 | ATM, BIRC3, MIR34B, MIR34C | |
| 7q11.1-q11.23 | 9 | 5.55E+07 | 2.17E+07 | 0.14934 | 0.14934 | ||
| 20q11.21-q11.22 | 5 | 2.96E+07 | 4.20E+06 | 0.14804 | 0.14934 | ||
| 20q13.13 | 7 | 4.89E+07 | 2.79E+05 | 0.17164 | 0.16885 | ||
| 11q24.2-q25.3 | 5 | 1.25E+08 | 9.52E+06 | 0.20946 | 0.19129 |
| Lesion . | Cytoband . | Frequency, % . | Start* . | Size, Kb* . | q value . | Residual q value . | Candidate genes . |
|---|---|---|---|---|---|---|---|
| Gains | |||||||
| 13q31.3 | 12 | 9.02E+07 | 2.40E+06 | 0.13392 | 0.13392 | MIR17HG | |
| Losses | |||||||
| 13q14.2-q14.3 | 29 | 5.07E+07 | 6.16E+05 | 7.17E-15 | 9.14E-15 | DLEU2/MIR15A/MIR16 | |
| 9p21.3 | 22 | 2.16E+07 | 8.94E+05 | 3.13E-05 | 3.13E-05 | CDKN2A | |
| 14q24.2-q32.33 | 16 | 7.11E+07 | 3.53E+07 | 7.71E-05 | 0.0013523 | TRAF3 | |
| 7q32.3-q36.2 | 12 | 1.31E+08 | 2.24E+07 | 0.0025523 | 0.0025523 | ||
| 1q42.12-q43 | 14 | 2.26E+08 | 1.11E+07 | 0.014836 | 0.014836 | ||
| 15q14-q15.1 | 9 | 3.89E+07 | 3.70E+06 | 0.026537 | 0.041218 | MGA | |
| 4q34.1-q35.2 | 10 | 1.74E+08 | 1.67E+07 | 0.11945 | 0.11556 | ||
| 9q33.3 | 16 | 1.28E+08 | 6.22E+05 | 0.12385 | 0.12385 | ||
| 15q11.2-q14 | 9 | 2.24E+07 | 1.24E+07 | 0.057148 | 0.12387 | ||
| 1p36.33-p34.2 | 14 | 1.00E+00 | 4.12E+07 | 0.13304 | 0.13304 | TNFRSF14 | |
| 11q21-q23.3 | 12 | 9.57E+07 | 2.16E+07 | 0.13304 | 0.13304 | ATM, BIRC3, MIR34B, MIR34C | |
| 7q11.1-q11.23 | 9 | 5.55E+07 | 2.17E+07 | 0.14934 | 0.14934 | ||
| 20q11.21-q11.22 | 5 | 2.96E+07 | 4.20E+06 | 0.14804 | 0.14934 | ||
| 20q13.13 | 7 | 4.89E+07 | 2.79E+05 | 0.17164 | 0.16885 | ||
| 11q24.2-q25.3 | 5 | 1.25E+08 | 9.52E+06 | 0.20946 | 0.19129 |
Numbering according to Genome Reference Consortium Human Build 37 (GRCh37) (hg19).