Clinical characteristics of the MM patients
| MM patient no. . | Age, y . | Patient stage . | BM plasma cells, % . | State of disease . |
|---|---|---|---|---|
| 1 | 80 | II | 85 | Diagnosis |
| 2 | 59 | III | 65 | Diagnosis |
| 3 | 67 | III | 60 | Diagnosis |
| 4 | 73 | III | 98 | Relapse |
| 5 | 73 | III | 60 | Relapse |
| MM patient no. . | Age, y . | Patient stage . | BM plasma cells, % . | State of disease . |
|---|---|---|---|---|
| 1 | 80 | II | 85 | Diagnosis |
| 2 | 59 | III | 65 | Diagnosis |
| 3 | 67 | III | 60 | Diagnosis |
| 4 | 73 | III | 98 | Relapse |
| 5 | 73 | III | 60 | Relapse |
Primary CD138+ MM cells were isolated from BM aspiration of MM patients at the diagnosis or relapse and were treated in vitro with MK-0457 (0.4 μM) or PHA-680632 (0.8 μM) and TRAIL (9.6 ng/mL) for 24 hours.