Table 1

Literature-cited clinical use of haptoglobin in Japan

Clinical conditionSubjects/controlsHaptoglobin dosePrimary finding (intention of treatment)Reference
Cardiopulmonary bypass surgery 16/21 6 g Prevention of acute renal failure Hashimoto et al87  
14/0 4 g Tanaka et al88  
Coronary artery bypass grafting in a patient with β-thalassemia and severe hemolysis Single case report  Horai et al89  
Peripheral blood stem cell transplantation Single case report 3 g Prevention of acute renal failure Tsuda et al90  
Hemolytic transfusion reaction Single case report 6 g Prevention of acute renal failure Homann et al91  
Massive transfusion 16/34 6 g Undetermined benefit Gando et al92  
Extracorporeal circulation 10/10 6 g Prevention of acute renal failure Kanamori et al93  
HELLP syndrome 17/17 3 g Prevention of acute renal failure Yamamoto et al94  
ABO-incompatible BM transplantation Two patient case reports 11 g Prevention of acute renal failure Ito et al95  
Thermal injury Single case report (repeated, large-dose therapy) > 20 g Improved outcome Imaizumi et al96  
Prevention of hemoglobinuria and acute renal failure Yoshioka et al97  
Glucose-6-phosphate dehydrogenase deficiency Single patient case report (24-mo-old boy) 8.5 g Prevention of hemoglobinuria Ohga et al98  
Adult patent ductus arteriosus, coil embolization Single patient case report 45 g Prevention of hemoglobinuria Eda et al99  
Clinical conditionSubjects/controlsHaptoglobin dosePrimary finding (intention of treatment)Reference
Cardiopulmonary bypass surgery 16/21 6 g Prevention of acute renal failure Hashimoto et al87  
14/0 4 g Tanaka et al88  
Coronary artery bypass grafting in a patient with β-thalassemia and severe hemolysis Single case report  Horai et al89  
Peripheral blood stem cell transplantation Single case report 3 g Prevention of acute renal failure Tsuda et al90  
Hemolytic transfusion reaction Single case report 6 g Prevention of acute renal failure Homann et al91  
Massive transfusion 16/34 6 g Undetermined benefit Gando et al92  
Extracorporeal circulation 10/10 6 g Prevention of acute renal failure Kanamori et al93  
HELLP syndrome 17/17 3 g Prevention of acute renal failure Yamamoto et al94  
ABO-incompatible BM transplantation Two patient case reports 11 g Prevention of acute renal failure Ito et al95  
Thermal injury Single case report (repeated, large-dose therapy) > 20 g Improved outcome Imaizumi et al96  
Prevention of hemoglobinuria and acute renal failure Yoshioka et al97  
Glucose-6-phosphate dehydrogenase deficiency Single patient case report (24-mo-old boy) 8.5 g Prevention of hemoglobinuria Ohga et al98  
Adult patent ductus arteriosus, coil embolization Single patient case report 45 g Prevention of hemoglobinuria Eda et al99  

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