Table 4

Univariate analyses of novel and known prognostic factors

Prognostic factorNEvent-free survival
Overall survival
HR95% CIPHR95% CIP
Response group        
    RR 81 1   1   
    SS 15 0.24 0.07-0.77 .016 No convergence†   
    SR 28 0.83 0.47-1.48 .530 0.89 0.48-1.75 .785 
    RS 7 1.37 0.55-3.45 .501 2.16 0.85-5.52 .107 
Cytogenetics risk        
    Not low* 62 1   1   
    Low* 30 0.64 0.36-1.17 .148 0.69 0.34-1.36 .281 
FLT3/ITD        
    Negative 113 1   1   
    Positive 15 2.27 1.21-4.23 .010 3.11 1.63-5.92 < .001 
CEBPα        
    Wild type 124 No convergence‡ No convergence‡     
    Mutated 4       
NPM1        
    Wild type 93 1   1   
    Mutated 9 0.71 0.26-1.95 .502 0.67 0.21-2.18 .510 
WBC        
    < 100 000 110 1   1   
    ≥ 100 000 29 1.67 1.00-2.80 .049 1.85 1.05-3.27 .034 
Prognostic factorNEvent-free survival
Overall survival
HR95% CIPHR95% CIP
Response group        
    RR 81 1   1   
    SS 15 0.24 0.07-0.77 .016 No convergence†   
    SR 28 0.83 0.47-1.48 .530 0.89 0.48-1.75 .785 
    RS 7 1.37 0.55-3.45 .501 2.16 0.85-5.52 .107 
Cytogenetics risk        
    Not low* 62 1   1   
    Low* 30 0.64 0.36-1.17 .148 0.69 0.34-1.36 .281 
FLT3/ITD        
    Negative 113 1   1   
    Positive 15 2.27 1.21-4.23 .010 3.11 1.63-5.92 < .001 
CEBPα        
    Wild type 124 No convergence‡ No convergence‡     
    Mutated 4       
NPM1        
    Wild type 93 1   1   
    Mutated 9 0.71 0.26-1.95 .502 0.67 0.21-2.18 .510 
WBC        
    < 100 000 110 1   1   
    ≥ 100 000 29 1.67 1.00-2.80 .049 1.85 1.05-3.27 .034 

HR indicates hazard ratio; and CI, confidence interval.

*

Low-risk cytogenetics: t(8;21) and inv(16).

†

SS group has 100% survival; therefore, RR, SR, RS groups are compared.

‡

CEBPα mutated group has 100% event-free and overall survival.

View Large
Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal