Table 2 Basal Stat3 and Stat5 signaling... | American Society of Hematology

Table 2

Basal Stat3 and Stat5 signaling parameters in AML samples and normal bone marrow

Parameter	AML			NBM			P*
Parameter	N	Median	Range	N	Median	Range	P*
Constitutive pY-Stat3, % positive	139	37.19	0.11-91.84	9	40.51	7.69-50.57	.490
Constitutive pS-Stat3, % positive	136	3.60	0.12-78.17	9	1.42	0.53-4.42	.01
Constitutive pY-Stat5, % positive	123	16.78	0.5-86.54	7	11.94	3.79-24.22	.21
Constitutive pY-Src, % positive	139	4.15	0.11-40.6	9	1.61	0.23-12.46	.058
Total Stat3, % positive	139	84.3	12.6-99.63	9	64.39	46.51-78.65	.002
G-CSF receptor, % positive	139	58.38	5.8-96.18	9	50.77	45.62-57.34	.208
gp130, IL-6 receptor; % positive	139	26.56	1.72-99.9	9	43.58	9.5-61.47	.432
SOCS3, relative densitometry	98	0.096	ND 1.79	10	0.038	ND 0.35	.527
SHP1, relative densitometry	98	6.61	ND 87.18	10	0.75	0.04-6.14	.001

Parameter	AML			NBM			P*
Parameter	N	Median	Range	N	Median	Range	P*
Constitutive pY-Stat3, % positive	139	37.19	0.11-91.84	9	40.51	7.69-50.57	.490
Constitutive pS-Stat3, % positive	136	3.60	0.12-78.17	9	1.42	0.53-4.42	.01
Constitutive pY-Stat5, % positive	123	16.78	0.5-86.54	7	11.94	3.79-24.22	.21
Constitutive pY-Src, % positive	139	4.15	0.11-40.6	9	1.61	0.23-12.46	.058
Total Stat3, % positive	139	84.3	12.6-99.63	9	64.39	46.51-78.65	.002
G-CSF receptor, % positive	139	58.38	5.8-96.18	9	50.77	45.62-57.34	.208
gp130, IL-6 receptor; % positive	139	26.56	1.72-99.9	9	43.58	9.5-61.47	.432
SOCS3, relative densitometry	98	0.096	ND 1.79	10	0.038	ND 0.35	.527
SHP1, relative densitometry	98	6.61	ND 87.18	10	0.75	0.04-6.14	.001

AML indicates acute myeloid leukemia; NBM, normal bone marrow; and ND, not detected.

Mann-Whitney U test. P values < .05 are shown in bold.