Univariate Cox regression models for impact of MRDpos status, entire study cohort (n = 253)
| . | CR1 (n = 183) . | CR2 (n = 70) . | All (n = 253) . |
|---|---|---|---|
| OS | |||
| MRDneg | 1 (reference) | 1 (reference) | 1 (reference) |
| MRDpos | 3.35 (2.02-5.55), P < .001 | 2.68 (1.25-5.74), P = .011 | 3.13 (2.06-4.76); P < .001 |
| MRD <0.1% | 2.91 (1.44-5.89);P = .003 | ||
| MRD 0.1%-1% | 2.79 (1.58-4.92); P < .001 | ||
| MRD >1% | 3.98 (2.13-7.46); P < .001 | ||
| DFS | |||
| MRDneg | 1 (reference) | 1 (reference) | 1 (reference) |
| MRDpos | 4.76 (2.97-7.65); P < .001 | 3.34 (1.65-6.77); P = .001 | 4.15 (2.81-6.13); P < .001 |
| MRD <0.1% | 3.93 (2.06-7.48); P < .001 | ||
| MRD 0.1%-1% | 3.22 (1.89-5.50); P < .001 | ||
| MRD >1% | 6.83 (3.84-12.13); P < .001 | ||
| Relapse | |||
| MRDneg | 1 (reference) | 1 (reference) | 1 (reference) |
| MRDpos | 5.60 (3.16-9.94); P < .001 | 4.84 (2.11-11.06); P < .001 | 5.19 (3.26-8.27); P < .001 |
| MRD <0.1% | 5.22 (2.52-10.81); P < .001 | ||
| MRD 0.1%-1% | 4.03 (2.16-7.53); P < .001 | ||
| MRD >1% | 8.13 (4.11-16.07); P < .001 | ||
| NRM | |||
| MRDneg | 1 (reference) | 1 (reference) | 1 (reference) |
| MRDpos | 3.41 (1.46-7.99); P = .005 | 1.14 (0.23-5.53); P = NS | 2.48 (1.18-5.21); P = .017 |
| MRD <0.1% | 1.85 (0.43-7.86); P = NS | ||
| MRD 0.1%-1% | 1.93 (0.67-5.57), P=NS | ||
| MRD >1% | 4.69 (1.59-13.84), P = .005 |
| . | CR1 (n = 183) . | CR2 (n = 70) . | All (n = 253) . |
|---|---|---|---|
| OS | |||
| MRDneg | 1 (reference) | 1 (reference) | 1 (reference) |
| MRDpos | 3.35 (2.02-5.55), P < .001 | 2.68 (1.25-5.74), P = .011 | 3.13 (2.06-4.76); P < .001 |
| MRD <0.1% | 2.91 (1.44-5.89);P = .003 | ||
| MRD 0.1%-1% | 2.79 (1.58-4.92); P < .001 | ||
| MRD >1% | 3.98 (2.13-7.46); P < .001 | ||
| DFS | |||
| MRDneg | 1 (reference) | 1 (reference) | 1 (reference) |
| MRDpos | 4.76 (2.97-7.65); P < .001 | 3.34 (1.65-6.77); P = .001 | 4.15 (2.81-6.13); P < .001 |
| MRD <0.1% | 3.93 (2.06-7.48); P < .001 | ||
| MRD 0.1%-1% | 3.22 (1.89-5.50); P < .001 | ||
| MRD >1% | 6.83 (3.84-12.13); P < .001 | ||
| Relapse | |||
| MRDneg | 1 (reference) | 1 (reference) | 1 (reference) |
| MRDpos | 5.60 (3.16-9.94); P < .001 | 4.84 (2.11-11.06); P < .001 | 5.19 (3.26-8.27); P < .001 |
| MRD <0.1% | 5.22 (2.52-10.81); P < .001 | ||
| MRD 0.1%-1% | 4.03 (2.16-7.53); P < .001 | ||
| MRD >1% | 8.13 (4.11-16.07); P < .001 | ||
| NRM | |||
| MRDneg | 1 (reference) | 1 (reference) | 1 (reference) |
| MRDpos | 3.41 (1.46-7.99); P = .005 | 1.14 (0.23-5.53); P = NS | 2.48 (1.18-5.21); P = .017 |
| MRD <0.1% | 1.85 (0.43-7.86); P = NS | ||
| MRD 0.1%-1% | 1.93 (0.67-5.57), P=NS | ||
| MRD >1% | 4.69 (1.59-13.84), P = .005 |
Values are given as hazard ratio (95% confidence interval [CI]), P value.
NS, not significant.