Genes selected for validation experiments
| Expression . | No. . | Gene symbol . | Protein function . |
|---|---|---|---|
| Down-regulated in patients of group ha | 1 | CDKN2C | Cyclin-dependent kinase 4 inhibitor C; member of the INK4 family of cyclin-dependent kinase inhibitors; interacts with CDK4 or CDK6; prevents the activation of the CDK kinases; functions as a cell growth regulator; controls cell-cycle G1 progression |
| 2 | RNF26 | Contains a C3HC5 type of RING finger involved in protein-DNA and protein-protein interactions | |
| 3 | UQCRH | Mitochondrial Hinge protein | |
| Up-regulated in patients of group hb | 4 | LRDD | Contains a leucine-rich repeat and a death domain; interacts with Fas and MAPK activating death domain-containing protein MADD; functions as an adaptor protein in signaling processes |
| 5 | HLA-DRB4 | HLA-DRB4 belongs to the HLA class II beta-chain paralogs | |
| 6 | ADCK2 | Uncharacterized aarF domain-containing protein kinase 2 | |
| 7 | C18orf8 | Uncharacterized protein C18orf8 of 657 aa | |
| 8 | HIAT1 | Putative tetracycline transporter-like protein | |
| Down-regulated in patients of group hb | 9 | GIMAP1 | Belongs to the GTP-binding immuno-associated nucleotide subfamily of nucleotide-binding proteins; is involved in the differentiation of Th cells; is critical for the development of mature B and T lymphocytes |
| 10 | DCAKD | Dephospho-CoA kinase domain-containing protein | |
| 11 | FKBP5 | Member of the immunophilin protein family; plays a role in immunoregulation and basic cellular processes | |
| 12 | GTPBP2 | GTP-binding protein member of superfamily capable of binding GTP or GDP | |
| 13 | FLJ20366 | Syntabulin is a microtubule-associated protein implicated in syntaxin transport | |
| Down-regulated in patients of group hc | 14 | ETV3 | Transcriptional repressor; contributes to growth arrest during terminal macrophage differentiation by repressing target genes |
| 15 | KIF5C | Microtubule-associated force-producing protein; may play a role in organelle transport | |
| 16 | RPS27 | Ribosomal protein | |
| 17 | PDE4B | Involved in many signal transduction pathways; may play an important role in platelet aggregation, hormone secretion, and immune cell activation | |
| 18 | DOCK4 | Membrane-associated cytoplasmic protein; functions as a guanine nucleotide exchange factor; is involved in the regulation of adherens junctions between cells | |
| 19 | RFX7 | Ribosomal protein that is a component of the 40S subunit | |
| 20 | KIAA1128 | Hypothetical protein of 588 aa | |
| Up-regulated in patients of group ha | 21 | MTHFD1L | Involved in the synthesis of tetrahydrofolate in the mitochondrion |
| Expression . | No. . | Gene symbol . | Protein function . |
|---|---|---|---|
| Down-regulated in patients of group ha | 1 | CDKN2C | Cyclin-dependent kinase 4 inhibitor C; member of the INK4 family of cyclin-dependent kinase inhibitors; interacts with CDK4 or CDK6; prevents the activation of the CDK kinases; functions as a cell growth regulator; controls cell-cycle G1 progression |
| 2 | RNF26 | Contains a C3HC5 type of RING finger involved in protein-DNA and protein-protein interactions | |
| 3 | UQCRH | Mitochondrial Hinge protein | |
| Up-regulated in patients of group hb | 4 | LRDD | Contains a leucine-rich repeat and a death domain; interacts with Fas and MAPK activating death domain-containing protein MADD; functions as an adaptor protein in signaling processes |
| 5 | HLA-DRB4 | HLA-DRB4 belongs to the HLA class II beta-chain paralogs | |
| 6 | ADCK2 | Uncharacterized aarF domain-containing protein kinase 2 | |
| 7 | C18orf8 | Uncharacterized protein C18orf8 of 657 aa | |
| 8 | HIAT1 | Putative tetracycline transporter-like protein | |
| Down-regulated in patients of group hb | 9 | GIMAP1 | Belongs to the GTP-binding immuno-associated nucleotide subfamily of nucleotide-binding proteins; is involved in the differentiation of Th cells; is critical for the development of mature B and T lymphocytes |
| 10 | DCAKD | Dephospho-CoA kinase domain-containing protein | |
| 11 | FKBP5 | Member of the immunophilin protein family; plays a role in immunoregulation and basic cellular processes | |
| 12 | GTPBP2 | GTP-binding protein member of superfamily capable of binding GTP or GDP | |
| 13 | FLJ20366 | Syntabulin is a microtubule-associated protein implicated in syntaxin transport | |
| Down-regulated in patients of group hc | 14 | ETV3 | Transcriptional repressor; contributes to growth arrest during terminal macrophage differentiation by repressing target genes |
| 15 | KIF5C | Microtubule-associated force-producing protein; may play a role in organelle transport | |
| 16 | RPS27 | Ribosomal protein | |
| 17 | PDE4B | Involved in many signal transduction pathways; may play an important role in platelet aggregation, hormone secretion, and immune cell activation | |
| 18 | DOCK4 | Membrane-associated cytoplasmic protein; functions as a guanine nucleotide exchange factor; is involved in the regulation of adherens junctions between cells | |
| 19 | RFX7 | Ribosomal protein that is a component of the 40S subunit | |
| 20 | KIAA1128 | Hypothetical protein of 588 aa | |
| Up-regulated in patients of group ha | 21 | MTHFD1L | Involved in the synthesis of tetrahydrofolate in the mitochondrion |