Table 6

Hematologic variables in adult mice according to genotype

PIT1+/+PIT1neo/neoPIT1lox/loxMx1-Cre-PIT1lox/lox
RBCs, 106/mm3 11.1 ± 0.5 8.7 ± 1.2** 9.1 ± 0.3 7.6 ± 0.2** 
Hemoglobin, g/dL 18.1 ± 1.2 14.6 ± 1.8** 18.7 ± 0.7 18.9 ± 0.7 
Mean corpuscular hemoglobin, pg 16.4 ± 0.6 16.8 ± 0.3 24.9 ± 0.9 20.6 ± 0.9* 
Mean corpuscular volume, μm 56.2 ± 1.3 59.8 ± 2.4* 51.4 ± 2.4 55.7 ± 4.5 
WBCs, 103/mm3 9.3 ± 1.8 10.2 ± 5.2 6.2 ± 1.9 9.1 ± 1.1* 
Platelets, 103/mm3 676 ± 271 814 ± 462 461 ± 91 331 ± 101 
Reticulocytes, % 5.2 ± 0.8 13.2 ± 1.4** 2.3 ± 0.3 4.1 ± 0.3* 
PIT1+/+PIT1neo/neoPIT1lox/loxMx1-Cre-PIT1lox/lox
RBCs, 106/mm3 11.1 ± 0.5 8.7 ± 1.2** 9.1 ± 0.3 7.6 ± 0.2** 
Hemoglobin, g/dL 18.1 ± 1.2 14.6 ± 1.8** 18.7 ± 0.7 18.9 ± 0.7 
Mean corpuscular hemoglobin, pg 16.4 ± 0.6 16.8 ± 0.3 24.9 ± 0.9 20.6 ± 0.9* 
Mean corpuscular volume, μm 56.2 ± 1.3 59.8 ± 2.4* 51.4 ± 2.4 55.7 ± 4.5 
WBCs, 103/mm3 9.3 ± 1.8 10.2 ± 5.2 6.2 ± 1.9 9.1 ± 1.1* 
Platelets, 103/mm3 676 ± 271 814 ± 462 461 ± 91 331 ± 101 
Reticulocytes, % 5.2 ± 0.8 13.2 ± 1.4** 2.3 ± 0.3 4.1 ± 0.3* 

The circulating blood of 3-month-old PIT1+/+, PIT1neo/neo, PIT1lox/lox, and Mx1-Cre;PIT1lox/lox mice was analyzed on a Vet ABC counter (SCIL). The data shown were obtained from a group of 5 mice. Values are means ± SEM.

*

P < .05 and **P < .01 for significant differences between PIT1neo/neo and PIT1+/+ mice and between Mx1-Cre;PIT1lox/lox mice and PIT1lox/lox controls.

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