Pre-CAR–T-cell infusion factors and association with infection density within 28 days after CAR–T-cell infusion using Poisson regression
| Pre-CAR–T-cell infusion variables . | Ratio of infection densities (95% CI) . | P . | Adjusted ratio of infection densities (95% CI) . | P . |
|---|---|---|---|---|
| Age | 1.00 (0.97-1.02) | .69 | ||
| Sex | 0.93 (0.47-1.85) | .83 | ||
| Disease type | ||||
| ALL vs CLL | 1.36 (0.60-0.37) | .46 | 2.68 (1.16-6.19) | .021 |
| ALL vs NHL | 2.01 (1.02-3.95) | .043 | 4.44 (2.06, 9.55) | <.001 |
| Prior autologous or allogeneic HCT | 0.70 (0.38-1.28) | .25 | ||
| Prior antitumor treatment regimens | ||||
| ≥4 vs <4 | 2.24 (1.10-4.54) | .017 | 3.53 (1.76-7.10) | <.001 |
| IgG <400 mg/dL prelymphodepletion | 1.01 (0.52-1.96) | .98 | ||
| ALC <200 cells per mm3 prelymphodepletion | 0.75 (0.38-1.48) | .42 | ||
| ANC <500 cells per mm3 prelymphodepletion | 1.84 (0.88-3.84) | .10 | ||
| ANC <500 cells per mm3 pre-CAR-T | 2.02 (1.08-3.78) | .024 | ||
| Lymphodepletion regimen | ||||
| Cy/Flu vs Cy/other | 0.64 (0.34-1.23) | .20 | ||
| CAR–T-cell dose, cells per kg | ||||
| 2 × 107 vs 2 × 105 | 3.06 (1.36-6.90) | <.001 | 7.86 (3.15-19.60) | <.001 |
| 2 × 107 vs 2 × 106 | 4.41 (2.13-9.17) | <.001 | 7.25 (3.51-14.99) | <.001 |
| Pre-CAR–T-cell infusion variables . | Ratio of infection densities (95% CI) . | P . | Adjusted ratio of infection densities (95% CI) . | P . |
|---|---|---|---|---|
| Age | 1.00 (0.97-1.02) | .69 | ||
| Sex | 0.93 (0.47-1.85) | .83 | ||
| Disease type | ||||
| ALL vs CLL | 1.36 (0.60-0.37) | .46 | 2.68 (1.16-6.19) | .021 |
| ALL vs NHL | 2.01 (1.02-3.95) | .043 | 4.44 (2.06, 9.55) | <.001 |
| Prior autologous or allogeneic HCT | 0.70 (0.38-1.28) | .25 | ||
| Prior antitumor treatment regimens | ||||
| ≥4 vs <4 | 2.24 (1.10-4.54) | .017 | 3.53 (1.76-7.10) | <.001 |
| IgG <400 mg/dL prelymphodepletion | 1.01 (0.52-1.96) | .98 | ||
| ALC <200 cells per mm3 prelymphodepletion | 0.75 (0.38-1.48) | .42 | ||
| ANC <500 cells per mm3 prelymphodepletion | 1.84 (0.88-3.84) | .10 | ||
| ANC <500 cells per mm3 pre-CAR-T | 2.02 (1.08-3.78) | .024 | ||
| Lymphodepletion regimen | ||||
| Cy/Flu vs Cy/other | 0.64 (0.34-1.23) | .20 | ||
| CAR–T-cell dose, cells per kg | ||||
| 2 × 107 vs 2 × 105 | 3.06 (1.36-6.90) | <.001 | 7.86 (3.15-19.60) | <.001 |
| 2 × 107 vs 2 × 106 | 4.41 (2.13-9.17) | <.001 | 7.25 (3.51-14.99) | <.001 |