Top 100 genes overexpressed in plasmablasts relative to memory B cells and proposed B-1 cells
ranking according to overexpression . | Plasmablast vs memory . | Plasmablast vs B1 . |
---|---|---|
1 | PRDM1 | FNDC3B |
2 | SLAMF7 | SLC7A11 |
3 | MKi-67 | PSAT1 |
4 | TNFRSF17 | HRASLS2 |
5 | SEMA4A | APOBEC3B |
6 | HIST1H3B | ALDH1L2 |
7 | BUB1 | AQP3 |
8 | APOBEC3B | DENND2C |
9 | DCAF12 | DCAF12 |
10 | TYMS | IGKV6-21 |
11 | IGKV6-21 | GLDC |
12 | IGKV2-40 | SLAMF7 |
13 | KIAA0101 | NUCB2 |
14 | TRIB1 | ITGA6 |
15 | FNDC3B | SLC1A4 |
16 | CD38 | FKBP11 |
17 | HPGD | HPGD |
18 | AQP3 | PRDM1 |
19 | SLC1A4 | TNFRSF17 |
20 | NUCB2 | NT5DC2 |
21 | SLC7A11 | MKI-67 |
22 | NT5DC2 | CDC6 |
23 | CCNB2 | TYMS |
24 | HRASLS2 | BMP8B |
25 | SLCO3A1 | BUB1 |
26 | DLGAP5 | SLC41A2 |
27 | XBP1 | DLGAP5 |
28 | SPN | SLCO3A1 |
29 | ASPM | CCNB2 |
30 | GLDC | KIAA0101 |
31 | V3-3 | ELL2 |
32 | TOP2A | TRIB1 |
33 | RRM2 | ESCO2 |
34 | PSAT1 | RRM2 |
35 | HIST1H2BB | PDIA5 |
36 | TP63 | TNFRSF17 |
37 | ELL2 | SLC44A1 |
38 | ALDH1L2 | AMPD1 |
39 | GPRC5D | SEC11C |
40 | GAB1 | ASPM |
41 | ESCO2 | VDR |
42 | MGC29506 | CDC20 |
43 | MANEA | IGLV7-46 |
44 | MYBL2 | DTL |
45 | DTL | C14orf145 |
46 | MAN1A1 | GPRIN3 |
47 | ITGA6 | HIST1H2AJ |
48 | TPX2 | SEMA4A |
49 | DENND2C | ELL2 |
50 | SKA3 | MANEA |
51 | CDC6 | CDKN3 |
52 | HIST1H1B | GPR155 |
53 | BMP8B | SEC24D |
54 | GPRIN3 | IGKV2-40 |
55 | FKBP11 | XBP1 |
56 | IGLV6-57 | SPN |
57 | VDR | IGLV6-57 |
58 | SLC44A1 | MGC29506 |
59 | PDIA4 | GPRC5D |
60 | GRCh37:15 | SEPT10 |
61 | ELL2 | LMAN1 |
62 | TNFRSF17 | HSPA13 |
63 | CDK1 | WIPI1 |
64 | LEF1 | CNKSR1 |
65 | WARS | CHAC2 |
66 | SEC11C | TSHR |
67 | IGKV2-24 | TP63 |
68 | PDIA5 | FAM172B |
69 | κ constant | C17orf28 |
70 | SLC4A12 | BHLHA15 |
71 | CDC20 | IL6ST |
72 | HSPA13 | SLC7A5 |
73 | SEC24D | RCC1 |
74 | NCAPG | FKBP14 |
75 | RCC1 | SELS |
76 | GRCH37:2 | GRCH37:15 |
77 | GPR155 | WARS |
78 | NCRNA00152 | PDIA4 |
79 | C14orf145 | HIST1H3B |
80 | CDKN3 | IL2RB |
81 | CASP3 | EIF4E3 |
82 | WIPI1 | CDK1 |
83 | MGC:178074 | HYOU1 |
84 | HIST1H3F | HIST1H2BB |
85 | HIST1H2AJ | SPATS2 |
86 | SELS | CASP3 |
87 | BHLA15 | CAV1 |
88 | LDLR | GRCh37e:3 |
89 | CENPF | DERL3 |
90 | PLK1 | GRCH37:14 |
91 | NUSAP1 | TXNDC11 |
92 | RUNX2 | LARP1B |
93 | SELPLG | GGH |
94 | HIST1H3J | CCR10 |
95 | CAV1 | CCNA2 |
96 | NCRNA00152 | PERP |
97 | C17orf28 | NCAPG |
98 | KIF23 | TOP2A |
99 | CNKSR1 | IGKV2OR22-4 |
100 | IL2RB | ADA |
ranking according to overexpression . | Plasmablast vs memory . | Plasmablast vs B1 . |
---|---|---|
1 | PRDM1 | FNDC3B |
2 | SLAMF7 | SLC7A11 |
3 | MKi-67 | PSAT1 |
4 | TNFRSF17 | HRASLS2 |
5 | SEMA4A | APOBEC3B |
6 | HIST1H3B | ALDH1L2 |
7 | BUB1 | AQP3 |
8 | APOBEC3B | DENND2C |
9 | DCAF12 | DCAF12 |
10 | TYMS | IGKV6-21 |
11 | IGKV6-21 | GLDC |
12 | IGKV2-40 | SLAMF7 |
13 | KIAA0101 | NUCB2 |
14 | TRIB1 | ITGA6 |
15 | FNDC3B | SLC1A4 |
16 | CD38 | FKBP11 |
17 | HPGD | HPGD |
18 | AQP3 | PRDM1 |
19 | SLC1A4 | TNFRSF17 |
20 | NUCB2 | NT5DC2 |
21 | SLC7A11 | MKI-67 |
22 | NT5DC2 | CDC6 |
23 | CCNB2 | TYMS |
24 | HRASLS2 | BMP8B |
25 | SLCO3A1 | BUB1 |
26 | DLGAP5 | SLC41A2 |
27 | XBP1 | DLGAP5 |
28 | SPN | SLCO3A1 |
29 | ASPM | CCNB2 |
30 | GLDC | KIAA0101 |
31 | V3-3 | ELL2 |
32 | TOP2A | TRIB1 |
33 | RRM2 | ESCO2 |
34 | PSAT1 | RRM2 |
35 | HIST1H2BB | PDIA5 |
36 | TP63 | TNFRSF17 |
37 | ELL2 | SLC44A1 |
38 | ALDH1L2 | AMPD1 |
39 | GPRC5D | SEC11C |
40 | GAB1 | ASPM |
41 | ESCO2 | VDR |
42 | MGC29506 | CDC20 |
43 | MANEA | IGLV7-46 |
44 | MYBL2 | DTL |
45 | DTL | C14orf145 |
46 | MAN1A1 | GPRIN3 |
47 | ITGA6 | HIST1H2AJ |
48 | TPX2 | SEMA4A |
49 | DENND2C | ELL2 |
50 | SKA3 | MANEA |
51 | CDC6 | CDKN3 |
52 | HIST1H1B | GPR155 |
53 | BMP8B | SEC24D |
54 | GPRIN3 | IGKV2-40 |
55 | FKBP11 | XBP1 |
56 | IGLV6-57 | SPN |
57 | VDR | IGLV6-57 |
58 | SLC44A1 | MGC29506 |
59 | PDIA4 | GPRC5D |
60 | GRCh37:15 | SEPT10 |
61 | ELL2 | LMAN1 |
62 | TNFRSF17 | HSPA13 |
63 | CDK1 | WIPI1 |
64 | LEF1 | CNKSR1 |
65 | WARS | CHAC2 |
66 | SEC11C | TSHR |
67 | IGKV2-24 | TP63 |
68 | PDIA5 | FAM172B |
69 | κ constant | C17orf28 |
70 | SLC4A12 | BHLHA15 |
71 | CDC20 | IL6ST |
72 | HSPA13 | SLC7A5 |
73 | SEC24D | RCC1 |
74 | NCAPG | FKBP14 |
75 | RCC1 | SELS |
76 | GRCH37:2 | GRCH37:15 |
77 | GPR155 | WARS |
78 | NCRNA00152 | PDIA4 |
79 | C14orf145 | HIST1H3B |
80 | CDKN3 | IL2RB |
81 | CASP3 | EIF4E3 |
82 | WIPI1 | CDK1 |
83 | MGC:178074 | HYOU1 |
84 | HIST1H3F | HIST1H2BB |
85 | HIST1H2AJ | SPATS2 |
86 | SELS | CASP3 |
87 | BHLA15 | CAV1 |
88 | LDLR | GRCh37e:3 |
89 | CENPF | DERL3 |
90 | PLK1 | GRCH37:14 |
91 | NUSAP1 | TXNDC11 |
92 | RUNX2 | LARP1B |
93 | SELPLG | GGH |
94 | HIST1H3J | CCR10 |
95 | CAV1 | CCNA2 |
96 | NCRNA00152 | PERP |
97 | C17orf28 | NCAPG |
98 | KIF23 | TOP2A |
99 | CNKSR1 | IGKV2OR22-4 |
100 | IL2RB | ADA |
Different B cell subsets were sorted and gene expression analysis was performed on sorted populations. The top 100 genes that were overexpressed in plasmablasts compared with memory B cells (left column) and in plasmablasts compared with proposed B-1 cells (right column) are listed, ranked in descending order of difference in expression. Genes depicted in bold have been associated with plasma cell differentiation23-25 or have been associated with a plasma cell–specific biological network, as defined by Jourdan et al, 2009.25