MRD class stratification and postinduction therapy assignment
| MRD class . | MRD day 33 (TP1) . | MRD day 79 (TP2) . | HR criteria* . | Postinduction treatment arm . |
|---|---|---|---|---|
| MRD-SR | Negative | Negative | No | SR protocol |
| MRD-MR | Positive | Negative | No | IR protocol |
| Positive, low MRD level (<10−3) | Positive, low MRD level (<10−3) | No | ||
| MRD-SER | Positive, high MRD level (≥10−3) | Positive, low MRD level (<10−3) | No | |
| −/− | MRD not available | MRD not available | No | |
| MRD-HR | Positive | Positive, high MRD level (≥10−3) | No | HR protocol |
| Variable | Negative or positive or not available | Negative or positive or not available | Yes |
| MRD class . | MRD day 33 (TP1) . | MRD day 79 (TP2) . | HR criteria* . | Postinduction treatment arm . |
|---|---|---|---|---|
| MRD-SR | Negative | Negative | No | SR protocol |
| MRD-MR | Positive | Negative | No | IR protocol |
| Positive, low MRD level (<10−3) | Positive, low MRD level (<10−3) | No | ||
| MRD-SER | Positive, high MRD level (≥10−3) | Positive, low MRD level (<10−3) | No | |
| −/− | MRD not available | MRD not available | No | |
| MRD-HR | Positive | Positive, high MRD level (≥10−3) | No | HR protocol |
| Variable | Negative or positive or not available | Negative or positive or not available | Yes |
HR, high risk; IR, intermediate risk.
HR criteria: prednisone poor response (≥1000 leukemic blasts per microliter in the peripheral blood on day 8), or failure to achieve remission (ie, with >5% leukemic blasts in the BM on day 33, or persistent extramedullary disease) after induction phase IA (induction failure), or positivity for MLL/AF4 fusion transcript.