Multivariate analysis summary: comparison with 8/8 matches and comparison among 7/8 groups
| Outcome . | 8/8 matched . | 7/8 HVG HR (95% CI), P value . | 7/8 GVH HR (95% CI), P value . | 7/8 bidirectional HR (95% CI), P value . | 7/8 groups only P value* . |
|---|---|---|---|---|---|
| Overall survival | 1.00 | 1.37 (1.04-1.81), .03 (NS) | 1.67 (1.27-2.18), .0002 | 1.29 (1.15-1.46), <.0001 | .17 (NS) |
| Disease-free survival | 1.00 | 1.38 (1.07-1.78), .013 (NS) | 1.53 (1.19-1.96), .001 | 1.35 (1.20-1.50), <.0001 | .60 (NS) |
| TRM | 1.00 | 1.44 (1.05-1.97), .025 (NS) | 1.82 (1.37-2.42), <.0001 | 1.56 (1.36-1.79), <.0001 | .46 (NS) |
| Relapse | 1.00 | 1.38 (0.97-1.95), .07 (NS) | 1.11 (0.76-1.63), .60 (NS) | 0.98 (0.84-1.16), .83 (NS) | .15 (NS) |
| Acute GVHD III-IV | 1.00 | 0.83 (0.55-1.27), .39 (NS) | 1.92 (1.40-2.62), <.0001 | 1.61 (1.38-1.88), <.0001 | .003 |
| Chronic GVHD | 1.00 | 0.82 (0.57-1.19), .30 (NS) | 0.98 (0.69-1.39), .90 (NS) | 1.02 (0.89-1.18), .77 (NS) | .51 (NS) |
| Neutrophil engraftment | 1.00 | 0.86 (0.67-1.10), .23 (NS) | 1.11 (0.87-1.40), .40 (NS) | 0.99 (0.89-1.09), .78 (NS) | .31 (NS) |
| Graft failure | 1.00 | 1.21 (0.43-3.40), .71 (NS) | 1.97 (0.88-4.41), .10 (NS) | 1.66 (1.12-2.45), .011 (NS) | .74 (NS) |
| Outcome . | 8/8 matched . | 7/8 HVG HR (95% CI), P value . | 7/8 GVH HR (95% CI), P value . | 7/8 bidirectional HR (95% CI), P value . | 7/8 groups only P value* . |
|---|---|---|---|---|---|
| Overall survival | 1.00 | 1.37 (1.04-1.81), .03 (NS) | 1.67 (1.27-2.18), .0002 | 1.29 (1.15-1.46), <.0001 | .17 (NS) |
| Disease-free survival | 1.00 | 1.38 (1.07-1.78), .013 (NS) | 1.53 (1.19-1.96), .001 | 1.35 (1.20-1.50), <.0001 | .60 (NS) |
| TRM | 1.00 | 1.44 (1.05-1.97), .025 (NS) | 1.82 (1.37-2.42), <.0001 | 1.56 (1.36-1.79), <.0001 | .46 (NS) |
| Relapse | 1.00 | 1.38 (0.97-1.95), .07 (NS) | 1.11 (0.76-1.63), .60 (NS) | 0.98 (0.84-1.16), .83 (NS) | .15 (NS) |
| Acute GVHD III-IV | 1.00 | 0.83 (0.55-1.27), .39 (NS) | 1.92 (1.40-2.62), <.0001 | 1.61 (1.38-1.88), <.0001 | .003 |
| Chronic GVHD | 1.00 | 0.82 (0.57-1.19), .30 (NS) | 0.98 (0.69-1.39), .90 (NS) | 1.02 (0.89-1.18), .77 (NS) | .51 (NS) |
| Neutrophil engraftment | 1.00 | 0.86 (0.67-1.10), .23 (NS) | 1.11 (0.87-1.40), .40 (NS) | 0.99 (0.89-1.09), .78 (NS) | .31 (NS) |
| Graft failure | 1.00 | 1.21 (0.43-3.40), .71 (NS) | 1.97 (0.88-4.41), .10 (NS) | 1.66 (1.12-2.45), .011 (NS) | .74 (NS) |
The “7/8 groups only” column represents the overall P value (2 df test) for the comparison of the 7/8 HVG MM, 7/8 GVH MM, and 7/8 bidirectional groups. The 7/8 groups are not considered significantly different if P > .01. All P values not meeting the P < .01 threshold for statistical significance are labeled “NS.”