Table 1

Examples of HLA histocompatibility groups in study

Donor (graft)*Recipient (host)*Match category† (A, B, C, DRB1)Vector of mismatchGuideline for 7/8 matching
A*02:01, A*02:01 A*02:01, A*02:01 8/8 match   
Homozygous Homozygous 
A*02:01, A*03:01 A*02:01, A*02:01 7/8 mismatch HVG Less risk of GVHD compared with bidirectional mismatch 
Heterozygous Homozygous 
A*02:01, A*02:01 A*02:01, A*03:01 7/8 mismatch GVH Same risks as bidirectional mismatch 
Homozygous Heterozygous 
A*01:01, A*02:01 A*03:01, A*02:01 7/8 mismatch Bidirectional (HVG and GVH)  
Heterozygous Heterozygous 
Donor (graft)*Recipient (host)*Match category† (A, B, C, DRB1)Vector of mismatchGuideline for 7/8 matching
A*02:01, A*02:01 A*02:01, A*02:01 8/8 match   
Homozygous Homozygous 
A*02:01, A*03:01 A*02:01, A*02:01 7/8 mismatch HVG Less risk of GVHD compared with bidirectional mismatch 
Heterozygous Homozygous 
A*02:01, A*02:01 A*02:01, A*03:01 7/8 mismatch GVH Same risks as bidirectional mismatch 
Homozygous Heterozygous 
A*01:01, A*02:01 A*03:01, A*02:01 7/8 mismatch Bidirectional (HVG and GVH)  
Heterozygous Heterozygous 
*

Examples only; mismatches at all 4 loci, HLA-A, HLA-B, HLA-C, and HLA-DRB1, were included in study. Mismatched alleles are highlighted in bold text.

†

Match category assumes that alleles at all other loci (B, C, DRB1) are matched in these examples.

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