Table 1

Cox regression modeling of time to any MDS-CA, persistent MDS-CA, and clinical MDS/AL from various landmarks

Time to MDS-CATime to persistent MDS-CATime to clinical MDS/AL
Variablen/N (%)HR (95% CI)P valueHR (95% CI)P valueHR (95% CI)P value
From baseline         
 Univariate         
 Age ≥ 65 y 246/1080 (23) 1.87 (1.27, 2.75) .002 2.16 (1.13, 4.13) .020 1.53 (0.72, 3.26) .272 
 Male 655/1080 (61) 2.26 (1.48, 3.44) <.001 2.36 (1.12, 4.94) .023 1.83 (0.89, 3.78) .103 
 B2M > 5.5 mg/L 223/1077 (21) 1.96 (1.30, 2.97) .001 1.45 (0.67, 3.14) .347 1.67 (0.76, 3.66) .202 
 TT2-Thal 316/1080 (29) 0.59 (0.39, 0.90) .015 0.41 (0.18, 0.93) .034 0.41 (0.18, 0.94) .035 
 TT2+Thal 300/1080 (28) 0.72 (0.48, 1.07) .102 0.61 (0.30, 1.23) .165 0.87 (0.43, 1.73) .685 
 TT3a 296/1080 (27) 1.32 (0.88, 1.98) .180 1.72 (0.87, 3.37) .116 2.34 (1.10, 5.00) .028 
 TT3b 168/1080 (16) 4.14 (2.46, 6.96) <.001 6.29 (2.58, 15.37) <.001 2.62 (0.83, 8.24) .099 
 Multivariate         
 Age ≥ 65 y 245/1077 (23) 1.77 (1.19, 2.63) .005 2.13 (1.11, 4.10) .024   
 Male 652/1077 (61) 2.33 (1.52, 3.56) <.001 2.32 (1.10, 4.88) .026   
 B2M > 5.5 mg/L 223/1077 (21) 1.81 (1.19, 2.77) .006 1.28 (0.58, 2.81) .541   
 TT3b 165/1077 (15) 3.71 (2.18, 6.30) <.001 6.02 (2.46, 14.72) <.001   
With time-dependent variable    
 Univariate         
 Age ≥65 y 246/1080 (23) 1.87 (1.27, 2.75) .002 2.16 (1.13, 4.13) .020 1.53 (0.72, 3.26) .272 
 Male 655/1080 (61) 2.26 (1.48, 3.44) <.001 2.36 (1.12, 4.94) .023 1.83 (0.89, 3.78) .103 
 B2M >5.5 mg/L 223/1077 (21) 1.96 (1.30, 2.97) .001 1.45 (0.67, 3.14) .347 1.67 (0.76, 3.66) .202 
 TT2-Thal 316/1080 (29) 0.59 (0.39, 0.90) .015 0.41 (0.18, 0.93) .034 0.41 (0.18, 0.94) .035 
 TT2+Thal 300/1080 (28) 0.72 (0.48, 1.07) .102 0.61 (0.30, 1.23) .165 0.87 (0.43, 1.73) .685 
 TT3a 296/1080 (27) 1.32 (0.88, 1.98) .180 1.72 (0.87, 3.37) .116 2.34 (1.10, 5.00) .028 
 TT3b 168/1080 (16) 4.14 (2.46, 6.96) <.001 6.29 (2.58, 15.37) <.001 2.62 (0.83, 8.24) .099 
 Relapse before last cytogenetic test*** N = 1080 1.66 (1.17, 2.37) .005 0.89 (0.48, 1.68) .725 1.76 (0.92, 3.35) .087 
 Multivariate         
 Age ≥ 65 y 245/1077 (23) 1.89 (1.27, 2.81) .002 2.14 (1.11, 4.13) .023   
 Male 652/1077 (61) 2.23 (1.46, 3.41) <.001 2.31 (1.10, 4.87) .027   
 B2M > 5.5 mg/L 223/1077 (21) 1.67 (1.09, 2.57) .018 1.27 (0.58, 2.80) .553   
 TT3b 165/1077 (15) 4.46 (2.60, 7.67) <.001 6.12 (2.46, 15.23) <.001   
 Relapse before last cytogenetic test*** N = 1077 1.90 (1.31, 2.75) <.001 1.06 (0.55, 2.03) .863   
From first transplant    
 Univariate         
 Age ≥65 y 211/981 (22) 2.00 (1.35, 2.97) <.001 2.29 (1.20, 4.38) .012 1.72 (0.80, 3.69) .162 
 Male 602/981 (61) 2.24 (1.46, 3.45) <.001 2.32 (1.11, 4.86) .026 2.05 (0.96, 4.37) .062 
 B2M > 5.5 mg/L 187/979 (19) 1.88 (1.22, 2.89) .004 1.54 (0.71, 3.33) .276 1.55 (0.68, 3.53) .302 
 TT2-Thal 283/981 (29) 0.61 (0.40, 0.93) .022 0.40 (0.18, 0.91) .030 0.43 (0.19, 0.99) .049 
 TT2+Thal 268/981 (27) 0.73 (0.49, 1.09) .124 0.62 (0.31, 1.25) .179 0.91 (0.45, 1.82) .786 
 TT3a 275/981 (28) 1.29 (0.85, 1.95) .236 1.73 (0.88, 3.39) .112 2.05 (0.95, 4.45) .068 
 TT3b 155/981 (16) 4.13 (2.43, 7.04) <.001 6.35 (2.59, 15.55) <.001 2.72 (0.86, 8.64) .090 
 Multivariate         
 Age ≥65 y 210/970 (22) 1.89 (1.26, 2.82) .002 2.03 (1.05, 3.90) .034   
 Male 598/970 (62) 2.24 (1.45, 3.45) <.001 2.22 (1.05, 4.66) .036   
 B2M >5.5 mg/L 184/970 (19) 1.75 (1.12, 2.73) .013 1.46 (0.66, 3.21) .345   
 TT3b 153/970 (16) 3.77 (2.19, 6.49) <.001 5.34 (2.18, 13.11) <.001   
From start of maintenance    
 Univariate         
 Age ≥65 y 130/651 (20) 2.15 (1.36, 3.40) <.001 2.96 (1.47, 5.96) .002 2.01 (0.88, 4.58) .095 
 Male 411/651 (63) 1.99 (1.23, 3.22) .005 2.07 (0.94, 4.58) .072 1.45 (0.66, 3.17) .350 
 B2M >5.5 mg/L 106/650 (16) 2.03 (1.23, 3.34) .005 1.71 (0.75, 3.94) .204 2.19 (0.94, 5.11) .070 
 TT2-Thal 155/651 (24) 0.73 (0.44, 1.21) .227 0.54 (0.22, 1.30) .168 0.56 (0.22, 1.37) .202 
 TT2+Thal 171/651 (26) 0.77 (0.48, 1.22) .265 0.69 (0.32, 1.50) .351 0.98 (0.45, 2.11) .957 
 TT3a 211/651 (32) 0.94 (0.59, 1.51) .812 1.08 (0.52, 2.26) .841 1.26 (0.54, 2.93) .589 
 TT3b 114/651 (18) 3.57 (1.98, 6.42) <.001 5.86 (2.23, 15.41) <.001 2.67 (0.82, 8.65) .102 
 Cumulative dexamethasone prior to maintenance (g) N = 651 0.71 (0.51, 0.99) .046 0.88 (0.54, 1.42) .599 0.73 (0.41, 1.30) .285 
 CD34 infused with first transplant <4 × 106/kg 83/648 (13) 1.69 (0.98, 2.90) .058 2.09 (0.94, 4.61) .069 1.63 (0.63, 4.27) .316 
 CD34 infused with second transplant <5 × 106/kg 113/595 (19) 2.14 (1.32, 3.48) .002 2.03 (0.89, 4.65) .093 2.44 (1.07, 5.60) .035 
 Multivariate         
 Age ≥65 y 98/594 (16) 1.69 (0.99, 2.90) .055 1.53 (0.61, 3.82) .365   
 Male 371/594 (62) 2.57 (1.49, 4.42) <.001 2.53 (0.99, 6.47) .052   
 B2M >5.5 mg/L 97/594 (16) 2.21 (1.29, 3.81) .004 1.82 (0.71, 4.63) .211   
 TT3b 105/594 (18) 2.06 (1.04, 4.10) .039 3.95 (1.21, 12.92) .023   
 Cumulative dexamethasone prior to maintenance (g) N = 594 0.70 (0.48, 1.04) .079 0.96 (0.57, 1.61) .871   
 CD34 infused with second transplant <5 × 106/kg 112/594 (19) 1.78 (1.03, 3.06) .039 1.69 (0.69, 4.15) .251 2.44 (1.07, 5.60) .035 
Time to MDS-CATime to persistent MDS-CATime to clinical MDS/AL
Variablen/N (%)HR (95% CI)P valueHR (95% CI)P valueHR (95% CI)P value
From baseline         
 Univariate         
 Age ≥ 65 y 246/1080 (23) 1.87 (1.27, 2.75) .002 2.16 (1.13, 4.13) .020 1.53 (0.72, 3.26) .272 
 Male 655/1080 (61) 2.26 (1.48, 3.44) <.001 2.36 (1.12, 4.94) .023 1.83 (0.89, 3.78) .103 
 B2M > 5.5 mg/L 223/1077 (21) 1.96 (1.30, 2.97) .001 1.45 (0.67, 3.14) .347 1.67 (0.76, 3.66) .202 
 TT2-Thal 316/1080 (29) 0.59 (0.39, 0.90) .015 0.41 (0.18, 0.93) .034 0.41 (0.18, 0.94) .035 
 TT2+Thal 300/1080 (28) 0.72 (0.48, 1.07) .102 0.61 (0.30, 1.23) .165 0.87 (0.43, 1.73) .685 
 TT3a 296/1080 (27) 1.32 (0.88, 1.98) .180 1.72 (0.87, 3.37) .116 2.34 (1.10, 5.00) .028 
 TT3b 168/1080 (16) 4.14 (2.46, 6.96) <.001 6.29 (2.58, 15.37) <.001 2.62 (0.83, 8.24) .099 
 Multivariate         
 Age ≥ 65 y 245/1077 (23) 1.77 (1.19, 2.63) .005 2.13 (1.11, 4.10) .024   
 Male 652/1077 (61) 2.33 (1.52, 3.56) <.001 2.32 (1.10, 4.88) .026   
 B2M > 5.5 mg/L 223/1077 (21) 1.81 (1.19, 2.77) .006 1.28 (0.58, 2.81) .541   
 TT3b 165/1077 (15) 3.71 (2.18, 6.30) <.001 6.02 (2.46, 14.72) <.001   
With time-dependent variable    
 Univariate         
 Age ≥65 y 246/1080 (23) 1.87 (1.27, 2.75) .002 2.16 (1.13, 4.13) .020 1.53 (0.72, 3.26) .272 
 Male 655/1080 (61) 2.26 (1.48, 3.44) <.001 2.36 (1.12, 4.94) .023 1.83 (0.89, 3.78) .103 
 B2M >5.5 mg/L 223/1077 (21) 1.96 (1.30, 2.97) .001 1.45 (0.67, 3.14) .347 1.67 (0.76, 3.66) .202 
 TT2-Thal 316/1080 (29) 0.59 (0.39, 0.90) .015 0.41 (0.18, 0.93) .034 0.41 (0.18, 0.94) .035 
 TT2+Thal 300/1080 (28) 0.72 (0.48, 1.07) .102 0.61 (0.30, 1.23) .165 0.87 (0.43, 1.73) .685 
 TT3a 296/1080 (27) 1.32 (0.88, 1.98) .180 1.72 (0.87, 3.37) .116 2.34 (1.10, 5.00) .028 
 TT3b 168/1080 (16) 4.14 (2.46, 6.96) <.001 6.29 (2.58, 15.37) <.001 2.62 (0.83, 8.24) .099 
 Relapse before last cytogenetic test*** N = 1080 1.66 (1.17, 2.37) .005 0.89 (0.48, 1.68) .725 1.76 (0.92, 3.35) .087 
 Multivariate         
 Age ≥ 65 y 245/1077 (23) 1.89 (1.27, 2.81) .002 2.14 (1.11, 4.13) .023   
 Male 652/1077 (61) 2.23 (1.46, 3.41) <.001 2.31 (1.10, 4.87) .027   
 B2M > 5.5 mg/L 223/1077 (21) 1.67 (1.09, 2.57) .018 1.27 (0.58, 2.80) .553   
 TT3b 165/1077 (15) 4.46 (2.60, 7.67) <.001 6.12 (2.46, 15.23) <.001   
 Relapse before last cytogenetic test*** N = 1077 1.90 (1.31, 2.75) <.001 1.06 (0.55, 2.03) .863   
From first transplant    
 Univariate         
 Age ≥65 y 211/981 (22) 2.00 (1.35, 2.97) <.001 2.29 (1.20, 4.38) .012 1.72 (0.80, 3.69) .162 
 Male 602/981 (61) 2.24 (1.46, 3.45) <.001 2.32 (1.11, 4.86) .026 2.05 (0.96, 4.37) .062 
 B2M > 5.5 mg/L 187/979 (19) 1.88 (1.22, 2.89) .004 1.54 (0.71, 3.33) .276 1.55 (0.68, 3.53) .302 
 TT2-Thal 283/981 (29) 0.61 (0.40, 0.93) .022 0.40 (0.18, 0.91) .030 0.43 (0.19, 0.99) .049 
 TT2+Thal 268/981 (27) 0.73 (0.49, 1.09) .124 0.62 (0.31, 1.25) .179 0.91 (0.45, 1.82) .786 
 TT3a 275/981 (28) 1.29 (0.85, 1.95) .236 1.73 (0.88, 3.39) .112 2.05 (0.95, 4.45) .068 
 TT3b 155/981 (16) 4.13 (2.43, 7.04) <.001 6.35 (2.59, 15.55) <.001 2.72 (0.86, 8.64) .090 
 Multivariate         
 Age ≥65 y 210/970 (22) 1.89 (1.26, 2.82) .002 2.03 (1.05, 3.90) .034   
 Male 598/970 (62) 2.24 (1.45, 3.45) <.001 2.22 (1.05, 4.66) .036   
 B2M >5.5 mg/L 184/970 (19) 1.75 (1.12, 2.73) .013 1.46 (0.66, 3.21) .345   
 TT3b 153/970 (16) 3.77 (2.19, 6.49) <.001 5.34 (2.18, 13.11) <.001   
From start of maintenance    
 Univariate         
 Age ≥65 y 130/651 (20) 2.15 (1.36, 3.40) <.001 2.96 (1.47, 5.96) .002 2.01 (0.88, 4.58) .095 
 Male 411/651 (63) 1.99 (1.23, 3.22) .005 2.07 (0.94, 4.58) .072 1.45 (0.66, 3.17) .350 
 B2M >5.5 mg/L 106/650 (16) 2.03 (1.23, 3.34) .005 1.71 (0.75, 3.94) .204 2.19 (0.94, 5.11) .070 
 TT2-Thal 155/651 (24) 0.73 (0.44, 1.21) .227 0.54 (0.22, 1.30) .168 0.56 (0.22, 1.37) .202 
 TT2+Thal 171/651 (26) 0.77 (0.48, 1.22) .265 0.69 (0.32, 1.50) .351 0.98 (0.45, 2.11) .957 
 TT3a 211/651 (32) 0.94 (0.59, 1.51) .812 1.08 (0.52, 2.26) .841 1.26 (0.54, 2.93) .589 
 TT3b 114/651 (18) 3.57 (1.98, 6.42) <.001 5.86 (2.23, 15.41) <.001 2.67 (0.82, 8.65) .102 
 Cumulative dexamethasone prior to maintenance (g) N = 651 0.71 (0.51, 0.99) .046 0.88 (0.54, 1.42) .599 0.73 (0.41, 1.30) .285 
 CD34 infused with first transplant <4 × 106/kg 83/648 (13) 1.69 (0.98, 2.90) .058 2.09 (0.94, 4.61) .069 1.63 (0.63, 4.27) .316 
 CD34 infused with second transplant <5 × 106/kg 113/595 (19) 2.14 (1.32, 3.48) .002 2.03 (0.89, 4.65) .093 2.44 (1.07, 5.60) .035 
 Multivariate         
 Age ≥65 y 98/594 (16) 1.69 (0.99, 2.90) .055 1.53 (0.61, 3.82) .365   
 Male 371/594 (62) 2.57 (1.49, 4.42) <.001 2.53 (0.99, 6.47) .052   
 B2M >5.5 mg/L 97/594 (16) 2.21 (1.29, 3.81) .004 1.82 (0.71, 4.63) .211   
 TT3b 105/594 (18) 2.06 (1.04, 4.10) .039 3.95 (1.21, 12.92) .023   
 Cumulative dexamethasone prior to maintenance (g) N = 594 0.70 (0.48, 1.04) .079 0.96 (0.57, 1.61) .871   
 CD34 infused with second transplant <5 × 106/kg 112/594 (19) 1.78 (1.03, 3.06) .039 1.69 (0.69, 4.15) .251 2.44 (1.07, 5.60) .035 

Bolding within the data ranges highlights the variables that were statistically significant. Confidence interval P value from Wald χ2 test in Cox regression. Multivariate results are not statistically significant at 0.05 level. All univariate P values are reported regardless of significance. The multivariate model uses stepwise selection with entry level 0.1; the variable remains if it meets the 0.05 level. A multivariate P value >.05 indicates the variable was forced into model, with significant variables chosen using stepwise selection.*** denotes a time-dependent variable.

CI, confidence interval; HR, hazard ratio; Thal, thalidomide.

View Large
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal