Causes of death reported in COMFORT-1 in both the ruxolitinib and placebo treatment arms at the time of primary data cutoff
| Ruxolitinib arm . | Placebo arm . | ||
|---|---|---|---|
| Cause . | Number of cases . | Cause . | Number of cases . |
| Muscular weakness and general deterioration | 1 | Staphylococcal infection | 1 |
| Subdural hematoma | 1 | Gastrointestinal hemorrhage | 1 |
| Acute myeloid leukemia | 1 | Intestinal perforation | 1 |
| Pneumonia | 2 | Pneumonia | 1 |
| Renal failure | 1 | Multiorgan failure | 1 |
| Sepsis | 2 | Sepsis | 2 |
| Metastatic non–small cell carcinoma | 1 | Disease progression | 4 |
| Total | 9 | Total | 11 |
| Ruxolitinib arm . | Placebo arm . | ||
|---|---|---|---|
| Cause . | Number of cases . | Cause . | Number of cases . |
| Muscular weakness and general deterioration | 1 | Staphylococcal infection | 1 |
| Subdural hematoma | 1 | Gastrointestinal hemorrhage | 1 |
| Acute myeloid leukemia | 1 | Intestinal perforation | 1 |
| Pneumonia | 2 | Pneumonia | 1 |
| Renal failure | 1 | Multiorgan failure | 1 |
| Sepsis | 2 | Sepsis | 2 |
| Metastatic non–small cell carcinoma | 1 | Disease progression | 4 |
| Total | 9 | Total | 11 |