Quantification of target cell killing dependent on CD20 organization
Profile of capping . | Percent of conjugates . | Conjugates with killing . |
---|---|---|
No capping | 17.6% (21/119)* | 42.9% (9/21) |
Capping | 82.4% (98/119)* | 68.4% (67/98) |
Localization of cap | ||
Capping elsewhere | 44.9% (44/98)† | 61.4% (27/44) |
Capping on contact side | 55.1% (54/98)† | 74.1% (40/54) |