Frequency of known TP53 3′UTR SNPs in DLBCL cohorts
| SNP ID . | Position† . | MAF‡ . | Heterozygous frequency . | Validation§ . | SNP occurrence* . | |
|---|---|---|---|---|---|---|
| First group (244) . | Second group (247) . | |||||
| rs8065799 | 9 A>C | N/A | N/A | — | 0 | 0 |
| rs1042526 | 37 A>T | N/A | N/A | Precious | 0 | 0 |
| rs35919705 | 105 C>T | 0.010 | 0.015 | Frequency | 0 | 0 |
| rs16956880 | 205 G>A | 0.032 | 0.024 | Cluster, Frequency, 1000Genome | 3 | 2 |
| rs79516338 | 309 G>A | N/A | 0.500 | Frequency | 0 | 0 |
| rs34486624 | 314 G>A | N/A | 0.020 | Frequency | 0 | 0 |
| rs17881366 | 328 G>A | 0.026 | 0.010 | Cluster, Frequency, 1000Genome | 0 | 0 |
| rs4968187 | 485 G>A | 0.035 | N/A | Cluster, Frequency, 1000Genome Precious | 11 | 5 |
| rs916131 | 491 G>A | N/A | N/A | Precious | 0 | 0 |
| rs916132 | 514 T>C | N/A | N/A | Precious | 0 | 0 |
| rs1811095 | 534 C>T | N/A | N/A | Cluster | 0 | 0 |
| rs35944977 | 534-535 TC>CT | N/A | N/A | — | 0 | 0 |
| rs1811096 | 535 C>T | N/A | N/A | — | 0 | 1 |
| rs17886358 | 569-570 GT>del | N/A | 0.435 | Cluster, Frequency | 0 | 0 |
| rs34607064 | 595 C>del | N/A | N/A | — | 0 | 0 |
| rs66759322 | 611 A>del | N/A | N/A | — | 0 | 0 |
| rs17879353 | 613 C>A | 0.007 | N/A | Cluster, Frequency | 1 | 1 |
| rs1042535 | 634 C>CG>G>GA | N/A | N/A | — | 0 | 0 |
| rs1794291 | 635 A>G | N/A | N/A | Cluster | 0 | 0 |
| rs34182553 | 674 C>del | N/A | N/A | — | 0 | 0 |
| rs77011241 | 773 C>T | N/A | 0.389 | Frequency, 1000Genome | 0 | 0 |
| rs35940853 | 798 T>del | N/A | N/A | — | 0 | 0 |
| rs17884306 | 826 G>A | 0.044 | N/A | Cluster, Frequency, 1000Genome, Precious | 17 | 24 |
| rs17884586 | 855 C>T | N/A | 0.012 | — | 0 | 0 |
| rs35659787 | 886 G>A | N/A | 0.10 | Frequency | 0 | 0 |
| rs55817367 | 925 C>T | 0.007 | N/A | 1000Genome | 0 | 0 |
| rs1794292 | 995 G>C | N/A | N/A | — | 0 | 0 |
| rs1794293 | 1057 C>G | N/A | N/A | — | 0 | 0 |
| rs114831472 | 1070 C>T | 0.032 | 0.065 | 1000Genome | 2 | 1 |
| rs78378222 | 1175 A>C | 0.010 | N/A | Cluster, Frequency, 1000Genome | 3 | 4 |
| SNP ID . | Position† . | MAF‡ . | Heterozygous frequency . | Validation§ . | SNP occurrence* . | |
|---|---|---|---|---|---|---|
| First group (244) . | Second group (247) . | |||||
| rs8065799 | 9 A>C | N/A | N/A | — | 0 | 0 |
| rs1042526 | 37 A>T | N/A | N/A | Precious | 0 | 0 |
| rs35919705 | 105 C>T | 0.010 | 0.015 | Frequency | 0 | 0 |
| rs16956880 | 205 G>A | 0.032 | 0.024 | Cluster, Frequency, 1000Genome | 3 | 2 |
| rs79516338 | 309 G>A | N/A | 0.500 | Frequency | 0 | 0 |
| rs34486624 | 314 G>A | N/A | 0.020 | Frequency | 0 | 0 |
| rs17881366 | 328 G>A | 0.026 | 0.010 | Cluster, Frequency, 1000Genome | 0 | 0 |
| rs4968187 | 485 G>A | 0.035 | N/A | Cluster, Frequency, 1000Genome Precious | 11 | 5 |
| rs916131 | 491 G>A | N/A | N/A | Precious | 0 | 0 |
| rs916132 | 514 T>C | N/A | N/A | Precious | 0 | 0 |
| rs1811095 | 534 C>T | N/A | N/A | Cluster | 0 | 0 |
| rs35944977 | 534-535 TC>CT | N/A | N/A | — | 0 | 0 |
| rs1811096 | 535 C>T | N/A | N/A | — | 0 | 1 |
| rs17886358 | 569-570 GT>del | N/A | 0.435 | Cluster, Frequency | 0 | 0 |
| rs34607064 | 595 C>del | N/A | N/A | — | 0 | 0 |
| rs66759322 | 611 A>del | N/A | N/A | — | 0 | 0 |
| rs17879353 | 613 C>A | 0.007 | N/A | Cluster, Frequency | 1 | 1 |
| rs1042535 | 634 C>CG>G>GA | N/A | N/A | — | 0 | 0 |
| rs1794291 | 635 A>G | N/A | N/A | Cluster | 0 | 0 |
| rs34182553 | 674 C>del | N/A | N/A | — | 0 | 0 |
| rs77011241 | 773 C>T | N/A | 0.389 | Frequency, 1000Genome | 0 | 0 |
| rs35940853 | 798 T>del | N/A | N/A | — | 0 | 0 |
| rs17884306 | 826 G>A | 0.044 | N/A | Cluster, Frequency, 1000Genome, Precious | 17 | 24 |
| rs17884586 | 855 C>T | N/A | 0.012 | — | 0 | 0 |
| rs35659787 | 886 G>A | N/A | 0.10 | Frequency | 0 | 0 |
| rs55817367 | 925 C>T | 0.007 | N/A | 1000Genome | 0 | 0 |
| rs1794292 | 995 G>C | N/A | N/A | — | 0 | 0 |
| rs1794293 | 1057 C>G | N/A | N/A | — | 0 | 0 |
| rs114831472 | 1070 C>T | 0.032 | 0.065 | 1000Genome | 2 | 1 |
| rs78378222 | 1175 A>C | 0.010 | N/A | Cluster, Frequency, 1000Genome | 3 | 4 |
Minor allele found in the initiation set (244 cases) or the validation set (247 cases). Some patients possess more than 1 SNP. Underlining in column 2 indicates SNPs found in the cohort.
Counted from first nucleotide of the TP53 3′UTR; “del,” deletion.
MAF, minor allele frequency; N/A, not available.
Validation: “Cluster,” multiple submissions mapped to the same location and clustered into 1 refSNP cluster and assigned a reference SNP ID number; “Frequency,” validated by both population frequency data and genotype data; “1000Genome,” validated by the 1000 Genomes Project; “Precious,” cited as clinically relevant in the literature and belonging to a reserved set of clinically associated SNPs in dbSNP.