Table 1

Expression of Tribbles increased in specific AML karyotypes and FAB subtypes

StudiesTrib1 (202241_at)Trib2 (202478_at)Trib3 (218145_at)
KaryotypeFABKaryotypeFABKaryotypeFAB
Valk et al* inv(16) or t(16; 16) M4 NS NS t(8;21) M2 
M5 t(15;17) M3 
Gutierrez et al10  inv(16) (p12; q13) M4Eo NS NS t(15;17)(q12;q21) M3 
Verhaak et al11  idt(16) M4 NS RAEB t(6;9) M2 
inv(16) M5 RAEB-t t(8;21) M3 
t(6;9) t(15;17) 
Haferlach et al12 * complex — complex — complex — 
t(8;21) inv(16) or t(16;16) t(15;17) 
Eppert et al13  +13 NS inv(16)(p13;q22) M4Eo NS NS 
inv(16)(p13;q22) 
StudiesTrib1 (202241_at)Trib2 (202478_at)Trib3 (218145_at)
KaryotypeFABKaryotypeFABKaryotypeFAB
Valk et al* inv(16) or t(16; 16) M4 NS NS t(8;21) M2 
M5 t(15;17) M3 
Gutierrez et al10  inv(16) (p12; q13) M4Eo NS NS t(15;17)(q12;q21) M3 
Verhaak et al11  idt(16) M4 NS RAEB t(6;9) M2 
inv(16) M5 RAEB-t t(8;21) M3 
t(6;9) t(15;17) 
Haferlach et al12 * complex — complex — complex — 
t(8;21) inv(16) or t(16;16) t(15;17) 
Eppert et al13  +13 NS inv(16)(p13;q22) M4Eo NS NS 
inv(16)(p13;q22) 

AML samples with unknown karyotype or FAB subtype were excluded from statistical analysis provided by the LGA.

NS, no statistically significant increased expression found; –,unavailable data for statistical analysis.

*

AML samples with normal karyotype were not able to be included in the statistical analysis.

Statistically significant increased expression with adjusted P < .05 in Welch’s t test.

Statistically highly significant increased expression with adjusted P < .001 in Welch’s t test.

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