Characteristics of adult patients with ETP-ALL and comparison between DNMT3A mutated and DNMT3A wild-type patients
| Characteristic . | DNMT3mut (n = 11) . | DNMT3wt (n = 57) . | P . | ||
|---|---|---|---|---|---|
| n . | % . | n . | % . | ||
| Sex | .35 | ||||
| Female | 3 | 27.3 | 10 | 17.6 | |
| Male | 8 | 72.7 | 47 | 82.4 | |
| Age, y | .02 | ||||
| Median | 63 | 37 | |||
| Range | 24-73 | 17-74 | |||
| Clinical data available | .27 | ||||
| n | 7 | 64 | 45 | 79 | |
| FLT3 | .41 | ||||
| Mutated | 3 | 27.3 | 21 | 36.8 | |
| Wild-type | 8 | 72.7 | 36 | 63.2 | |
| NOTCH1 | .68 | ||||
| Mutated | 1 | 9.1 | 9 | 15.8 | |
| Wild-type | 10 | 90.9 | 48 | 84.2 | |
| EZH2 | .52 | ||||
| Mutated | 1 | 9.1 | 3 | 5.3 | |
| Wild-type | 10 | 90.9 | 54 | 94.7 | |
| SH2B3 | .49 | ||||
| Mutated | 0 | 0 | 4 | 7 | |
| Wild-type | 11 | 100 | 53 | 93 | |
| SUZ12 | .84 | ||||
| Mutated | 0 | 0 | 1 | 1.8 | |
| Wild-type | 11 | 100 | 56 | 98.2 | |
| Characteristic . | DNMT3mut (n = 11) . | DNMT3wt (n = 57) . | P . | ||
|---|---|---|---|---|---|
| n . | % . | n . | % . | ||
| Sex | .35 | ||||
| Female | 3 | 27.3 | 10 | 17.6 | |
| Male | 8 | 72.7 | 47 | 82.4 | |
| Age, y | .02 | ||||
| Median | 63 | 37 | |||
| Range | 24-73 | 17-74 | |||
| Clinical data available | .27 | ||||
| n | 7 | 64 | 45 | 79 | |
| FLT3 | .41 | ||||
| Mutated | 3 | 27.3 | 21 | 36.8 | |
| Wild-type | 8 | 72.7 | 36 | 63.2 | |
| NOTCH1 | .68 | ||||
| Mutated | 1 | 9.1 | 9 | 15.8 | |
| Wild-type | 10 | 90.9 | 48 | 84.2 | |
| EZH2 | .52 | ||||
| Mutated | 1 | 9.1 | 3 | 5.3 | |
| Wild-type | 10 | 90.9 | 54 | 94.7 | |
| SH2B3 | .49 | ||||
| Mutated | 0 | 0 | 4 | 7 | |
| Wild-type | 11 | 100 | 53 | 93 | |
| SUZ12 | .84 | ||||
| Mutated | 0 | 0 | 1 | 1.8 | |
| Wild-type | 11 | 100 | 56 | 98.2 | |