CPSS: Variables and scores used for predicting likelihood of survival and leukemic evolution in the individual patient with CMML
| Variable . | Variable scores . | ||
|---|---|---|---|
| 0 . | 1 . | 2 . | |
| WHO subtype | CMML-1 blasts (including promonocytes) <5% in the PB and <10% in the BM | CMML-2 blasts (including promonocytes) from 5% to 19% in the PB and from 10% to 19% in the BM, or when Auer rods are present irrespective of blast count | — |
| FAB subtype | CMML-MD (WBC count <13 × 109/L) | CMML-MP (WBC count ≥13 × 109/L) | — |
| CMML-specific cytogenetic risk classification* | Low | Intermediate | High |
| RBC transfusion dependency† | No | Yes | — |
| Variable . | Variable scores . | ||
|---|---|---|---|
| 0 . | 1 . | 2 . | |
| WHO subtype | CMML-1 blasts (including promonocytes) <5% in the PB and <10% in the BM | CMML-2 blasts (including promonocytes) from 5% to 19% in the PB and from 10% to 19% in the BM, or when Auer rods are present irrespective of blast count | — |
| FAB subtype | CMML-MD (WBC count <13 × 109/L) | CMML-MP (WBC count ≥13 × 109/L) | — |
| CMML-specific cytogenetic risk classification* | Low | Intermediate | High |
| RBC transfusion dependency† | No | Yes | — |
WBC, white blood cell.
CMML-specific cytogenetic risk classification: low, normal and isolated –Y; intermediate, other abnormalities; and high, trisomy 8, complex karyotype (≥3 abnormalities), and abnormalities of chromosome 7.
RBC transfusion dependency was defined as having at least 1 RBC transfusion every 8 weeks over a period of 4 months.