Summary of top signals from a meta-analysis of cellular sensitivity to cytarabine (AUC)
| SNP . | Allele 1 . | Allele 2 . | Chrom . | Position . | Weight* . | P value . | Direction of effect† . |
|---|---|---|---|---|---|---|---|
| rs7729269 | t | c | 5 | 112748293 | 502 | 3.67E-07 | ++++++ |
| rs13189050 | t | c | 5 | 112734410 | 502 | 4.11E-07 | ++++++ |
| rs6594713 | a | c | 5 | 112743273 | 502 | 6.06E-07 | ++++++ |
| rs13181534 | t | c | 5 | 112752540 | 502 | 6.06E-07 | ++++++ |
| rs17068377 | t | g | 3 | 63327579 | 254 | 6.52E-07 | −−−??? |
| rs12638620 | c | g | 3 | 63329590 | 253 | 7.17E-07 | +++??? |
| rs17068392 | t | c | 3 | 63331024 | 253 | 7.17E-07 | +++??? |
| rs10510896 | a | g | 3 | 63330132 | 254 | 7.60E-07 | —??? |
| rs13068980 | a | g | 3 | 63325509 | 253 | 7.72E-07 | +++??? |
| rs10053341 | t | g | 5 | 112811906 | 511 | 8.18E-07 | −−−−−− |
| rs6870401 | c | g | 5 | 112766263 | 510 | 8.74E-07 | ++++++ |
| rs13171482 | a | g | 5 | 112729865 | 509 | 9.29E-07 | −−−−−− |
| rs6887482 | a | c | 5 | 112769332 | 501 | 1.02E-06 | ++++++ |
| rs12036333 | a | g | 1 | 237585689 | 175 | 1.31E-06 | −−???? |
| rs10061462 | a | t | 5 | 112754104 | 502 | 1.67E-06 | ++++++ |
| rs6550825 | a | g | 3 | 24009973 | 508 | 2.29E-06 | ++++++ |
| rs4956103 | c | g | 4 | 108619495 | 510 | 2.91E-06 | ++++++ |
| rs10758713 | a | g | 9 | 5862949 | 253 | 3.25E-06 | −−−??? |
| rs7714760 | t | c | 5 | 112763130 | 487 | 3.45E-06 | ++++++ |
| rs1567582 | a | c | 3 | 24011171 | 508 | 3.68E-06 | −−−−−− |
| rs6594714 | c | g | 5 | 112766519 | 509 | 3.91E-06 | ++++++ |
| rs2897047 | a | g | 5 | 2693123 | 492 | 4.06E-06 | ++++++ |
| rs7122539 | a | g | 11 | 66419307 | 489 | 4.19E-06 | −−−−−− |
| rs9883101 | a | c | 3 | 24019404 | 502 | 4.26E-06 | ++++++ |
| rs16873946 | a | g | 4 | 23239147 | 90 | 4.44E-06 | +????? |
| rs8037890 | t | g | 15 | 34953560 | 162 | 4.49E-06 | ?++??? |
| rs17808412 | c | g | 3 | 108622000 | 164 | 4.63E-06 | ?−−??? |
| rs1533140 | a | g | 3 | 24014384 | 508 | 4.81E-06 | ++++++ |
| rs6078860 | t | c | 20 | 12914738 | 164 | 4.99E-06 | ?−−??? |
| rs6550826 | c | g | 3 | 24009992 | 508 | 5.40E-06 | ++++++ |
| rs12498793 | t | c | 4 | 108617636 | 509 | 5.49E-06 | ++++++ |
| rs13174075 | a | t | 5 | 112823251 | 510 | 6.18E-06 | ++++++ |
| rs4073360 | a | g | 12 | 37161419 | 255 | 6.92E-06 | −−??−? |
| rs6883547 | a | g | 5 | 112944752 | 501 | 6.93E-06 | −−−−−− |
| rs6714052 | t | c | 2 | 6691777 | 163 | 7.30E-06 | ?−−??? |
| rs17202778 | t | c | 2 | 207943031 | 254 | 8.62E-06 | +++??? |
| rs12712936 | a | g | 2 | 45244339 | 510 | 8.93E-06 | −−−−−− |
| SNP . | Allele 1 . | Allele 2 . | Chrom . | Position . | Weight* . | P value . | Direction of effect† . |
|---|---|---|---|---|---|---|---|
| rs7729269 | t | c | 5 | 112748293 | 502 | 3.67E-07 | ++++++ |
| rs13189050 | t | c | 5 | 112734410 | 502 | 4.11E-07 | ++++++ |
| rs6594713 | a | c | 5 | 112743273 | 502 | 6.06E-07 | ++++++ |
| rs13181534 | t | c | 5 | 112752540 | 502 | 6.06E-07 | ++++++ |
| rs17068377 | t | g | 3 | 63327579 | 254 | 6.52E-07 | −−−??? |
| rs12638620 | c | g | 3 | 63329590 | 253 | 7.17E-07 | +++??? |
| rs17068392 | t | c | 3 | 63331024 | 253 | 7.17E-07 | +++??? |
| rs10510896 | a | g | 3 | 63330132 | 254 | 7.60E-07 | —??? |
| rs13068980 | a | g | 3 | 63325509 | 253 | 7.72E-07 | +++??? |
| rs10053341 | t | g | 5 | 112811906 | 511 | 8.18E-07 | −−−−−− |
| rs6870401 | c | g | 5 | 112766263 | 510 | 8.74E-07 | ++++++ |
| rs13171482 | a | g | 5 | 112729865 | 509 | 9.29E-07 | −−−−−− |
| rs6887482 | a | c | 5 | 112769332 | 501 | 1.02E-06 | ++++++ |
| rs12036333 | a | g | 1 | 237585689 | 175 | 1.31E-06 | −−???? |
| rs10061462 | a | t | 5 | 112754104 | 502 | 1.67E-06 | ++++++ |
| rs6550825 | a | g | 3 | 24009973 | 508 | 2.29E-06 | ++++++ |
| rs4956103 | c | g | 4 | 108619495 | 510 | 2.91E-06 | ++++++ |
| rs10758713 | a | g | 9 | 5862949 | 253 | 3.25E-06 | −−−??? |
| rs7714760 | t | c | 5 | 112763130 | 487 | 3.45E-06 | ++++++ |
| rs1567582 | a | c | 3 | 24011171 | 508 | 3.68E-06 | −−−−−− |
| rs6594714 | c | g | 5 | 112766519 | 509 | 3.91E-06 | ++++++ |
| rs2897047 | a | g | 5 | 2693123 | 492 | 4.06E-06 | ++++++ |
| rs7122539 | a | g | 11 | 66419307 | 489 | 4.19E-06 | −−−−−− |
| rs9883101 | a | c | 3 | 24019404 | 502 | 4.26E-06 | ++++++ |
| rs16873946 | a | g | 4 | 23239147 | 90 | 4.44E-06 | +????? |
| rs8037890 | t | g | 15 | 34953560 | 162 | 4.49E-06 | ?++??? |
| rs17808412 | c | g | 3 | 108622000 | 164 | 4.63E-06 | ?−−??? |
| rs1533140 | a | g | 3 | 24014384 | 508 | 4.81E-06 | ++++++ |
| rs6078860 | t | c | 20 | 12914738 | 164 | 4.99E-06 | ?−−??? |
| rs6550826 | c | g | 3 | 24009992 | 508 | 5.40E-06 | ++++++ |
| rs12498793 | t | c | 4 | 108617636 | 509 | 5.49E-06 | ++++++ |
| rs13174075 | a | t | 5 | 112823251 | 510 | 6.18E-06 | ++++++ |
| rs4073360 | a | g | 12 | 37161419 | 255 | 6.92E-06 | −−??−? |
| rs6883547 | a | g | 5 | 112944752 | 501 | 6.93E-06 | −−−−−− |
| rs6714052 | t | c | 2 | 6691777 | 163 | 7.30E-06 | ?−−??? |
| rs17202778 | t | c | 2 | 207943031 | 254 | 8.62E-06 | +++??? |
| rs12712936 | a | g | 2 | 45244339 | 510 | 8.93E-06 | −−−−−− |
These SNPs were evaluated in the patient population. Bold indicates SNPs associated with drug-induced cytotoxicity (P value shown) as well as drug-induced apoptosis in LCLs. Chrom, chromosome of host SNP.
Weight refers to the number of samples analyzed.
Order of populations: ASN, CEU1/2, CEU3, ASW, YRI1/2, and YRI3; the “?” means the SNP minor allele is absent in the corresponding population or the SNP has too low an MAF in that population for GWAS or the SNP did not meet a quality-control threshold (eg, imputation R2) for GWAS.