Results of subset analysis considering patient age, donor age, and donor source
| . | Grade 2-4 acute GVHD . | Grade 3-4 acute GVHD . | Chronic GVHD . | Overall mortality . | ||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Patients 50-59 y | ||||||||
| MUD <50 y (n = 550) | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| MSD ≥50 y (n = 1013) | 0.62 (0.53-0.73) | <.001 | 0.50 (0.41-0.62) | <.001 | 0.66 (0.56-0.77) | <.001 | 0.92 (0.81-1.05) | .22 |
| Patients ≥60 y | ||||||||
| MUD <50 y (n = 204) | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| MSD <67 y (n = 299) | 0.61 (0.46-0.81) | <.001 | 0.69 (0.47-0.99) | .043 | 0.73 (0.56-0.96) | .025 | 0.78 (0.63-0.97) | .028 |
| MSD ≥67 y (n = 94) | 0.67 (0.45-0.99) | .04 | 0.62 (0.36-1.06) | .08 | 0.61 (0.39-0.93) | .023 | 1.23 (0.92-1.63) | .16 |
| . | Grade 2-4 acute GVHD . | Grade 3-4 acute GVHD . | Chronic GVHD . | Overall mortality . | ||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Patients 50-59 y | ||||||||
| MUD <50 y (n = 550) | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| MSD ≥50 y (n = 1013) | 0.62 (0.53-0.73) | <.001 | 0.50 (0.41-0.62) | <.001 | 0.66 (0.56-0.77) | <.001 | 0.92 (0.81-1.05) | .22 |
| Patients ≥60 y | ||||||||
| MUD <50 y (n = 204) | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| MSD <67 y (n = 299) | 0.61 (0.46-0.81) | <.001 | 0.69 (0.47-0.99) | .043 | 0.73 (0.56-0.96) | .025 | 0.78 (0.63-0.97) | .028 |
| MSD ≥67 y (n = 94) | 0.67 (0.45-0.99) | .04 | 0.62 (0.36-1.06) | .08 | 0.61 (0.39-0.93) | .023 | 1.23 (0.92-1.63) | .16 |