Deregulated miRNAs in lymphoid neoplasms
| miRNA . | Disease . | Target Genes . | Genetic/Epigenetic deregulation . |
|---|---|---|---|
| miR-17-92 cluster (includes miR-17, miR-18a, miR-19a, miR-20a, miR-19b, and miR-92a) | DLBCL, MCL, Burkitt, FL, ALL | PTEN, BIM, CDKN1A, E2F TFs | Amplification upregulated by MLL |
| miR-155 | CLL, HD, pediatric Burkitt, DLBCL | Amplification | |
| miR-125a/miR-125b | DLBCL | TNFAIP3 | Amplification Upregulation |
| p15AS | AML, ALL | p15 | Upregulation |
| Tumor supressor miRNAs | |||
| miR-15a/miR-16-1 | CLL, NHL | BCL2, MCL-1 | Deleted Repressed by HDACs |
| miR-26a | Burkitt | EZH2 | Repressed by MYC |
| miR-29/miR-29b | CLL, MCL,DLBCL, Burkitt | CDK6,IGF-1R | Repressed by MYC |
| miR-31 | ATL | NIK | Repressed by PRC2 |
| miR-203 | MALT, ALL, CLL, MM | ABL1 | Promoter hypermethylation |
| miR-124 | ALL, NHL | CDK6 | Promoter hypermethylation |
| miRNA . | Disease . | Target Genes . | Genetic/Epigenetic deregulation . |
|---|---|---|---|
| miR-17-92 cluster (includes miR-17, miR-18a, miR-19a, miR-20a, miR-19b, and miR-92a) | DLBCL, MCL, Burkitt, FL, ALL | PTEN, BIM, CDKN1A, E2F TFs | Amplification upregulated by MLL |
| miR-155 | CLL, HD, pediatric Burkitt, DLBCL | Amplification | |
| miR-125a/miR-125b | DLBCL | TNFAIP3 | Amplification Upregulation |
| p15AS | AML, ALL | p15 | Upregulation |
| Tumor supressor miRNAs | |||
| miR-15a/miR-16-1 | CLL, NHL | BCL2, MCL-1 | Deleted Repressed by HDACs |
| miR-26a | Burkitt | EZH2 | Repressed by MYC |
| miR-29/miR-29b | CLL, MCL,DLBCL, Burkitt | CDK6,IGF-1R | Repressed by MYC |
| miR-31 | ATL | NIK | Repressed by PRC2 |
| miR-203 | MALT, ALL, CLL, MM | ABL1 | Promoter hypermethylation |
| miR-124 | ALL, NHL | CDK6 | Promoter hypermethylation |
ATL, adult T-cell leukemia.