Chromatin modifying enzymes deregulated in lymphoid neoplasms
| Genes . | Activity . | Genetic Deregulation . | Disease . | Implications . |
|---|---|---|---|---|
| EZH2 | H3K27 methyltransferase (PRC2 complex) | Mutation | FL | Increasing H3K27me3 level (FL, DLBCL, PMBL); Loss-of-function (T-ALL) |
| GCB-DLBCL | ||||
| PMBL | ||||
| T-ALL | ||||
| MLL2 | H3K4 methyltransferase | Mutation | FL | May result in reduced H3K4me3 level |
| Frame-shift | DLBCL | |||
| KDM2B | H3K36 methyltransferase | Mutation | DLBCL | Not known |
| UTX | H3K27 demethylase | Mutation | MM | Slowing of proliferation |
| MMSET | Histone methyltransferase | Activating translocation | MM | Affecting H3K27me3 and H3K36me2/3 levels |
| JMJD2C | H3K9 demethylase | Amplification | PMBL | Not known |
| HL | ||||
| MLL1 | H3K4 methyltransferase | Translocation | ALL | Not known |
| EED | PRC2 complex | Mutation | T-ALL | Loss-of-function, may result in reduced H3K27me3 |
| SUZ12 | PRC2 complex | Mutation | T-ALL | Loss-of-function, may result in reduced H3K27me3 |
| CREBBP | Histone acetyltransferase | Mutation | FL | Disrupting acetyltransferase and transcription co-activation activities |
| Deletion | DLBCL | |||
| ALL | ||||
| EP300 | Histone acetyltransferase | Mutation | FL | Disrupting acetyltransferase and transcription coactivation activities |
| Deletion | DLBCL | |||
| ARID1A | Chromatin remodeling SWI/SNF complex | Mutation | Pediatric-BL | May give malignant B-cell growth advantages |
| CLL | ||||
| CHD2 | Chromatin remodeling CHD family member | Mutation | CLL | Deregulation of histone variant H3.3 deposition |
| Genes . | Activity . | Genetic Deregulation . | Disease . | Implications . |
|---|---|---|---|---|
| EZH2 | H3K27 methyltransferase (PRC2 complex) | Mutation | FL | Increasing H3K27me3 level (FL, DLBCL, PMBL); Loss-of-function (T-ALL) |
| GCB-DLBCL | ||||
| PMBL | ||||
| T-ALL | ||||
| MLL2 | H3K4 methyltransferase | Mutation | FL | May result in reduced H3K4me3 level |
| Frame-shift | DLBCL | |||
| KDM2B | H3K36 methyltransferase | Mutation | DLBCL | Not known |
| UTX | H3K27 demethylase | Mutation | MM | Slowing of proliferation |
| MMSET | Histone methyltransferase | Activating translocation | MM | Affecting H3K27me3 and H3K36me2/3 levels |
| JMJD2C | H3K9 demethylase | Amplification | PMBL | Not known |
| HL | ||||
| MLL1 | H3K4 methyltransferase | Translocation | ALL | Not known |
| EED | PRC2 complex | Mutation | T-ALL | Loss-of-function, may result in reduced H3K27me3 |
| SUZ12 | PRC2 complex | Mutation | T-ALL | Loss-of-function, may result in reduced H3K27me3 |
| CREBBP | Histone acetyltransferase | Mutation | FL | Disrupting acetyltransferase and transcription co-activation activities |
| Deletion | DLBCL | |||
| ALL | ||||
| EP300 | Histone acetyltransferase | Mutation | FL | Disrupting acetyltransferase and transcription coactivation activities |
| Deletion | DLBCL | |||
| ARID1A | Chromatin remodeling SWI/SNF complex | Mutation | Pediatric-BL | May give malignant B-cell growth advantages |
| CLL | ||||
| CHD2 | Chromatin remodeling CHD family member | Mutation | CLL | Deregulation of histone variant H3.3 deposition |