Characteristics of AML mice caused by expression of D171N and BMI1
| Characteristics . | pMYs.IG/pMYs.IN (n = 3) . | D171N/pMYs.IN (n = 5) . | D171N/BMI1 (n = 10) . |
|---|---|---|---|
| WBCs (/μL) | 18 550 ± 1786 | 129 100 ± 68 089 | 70 838 ± 16 353 |
| Hb (g/dL) | 14.8 ± 0.4 | 7.3 ± 2.5 | 7.7 ± 2.3 |
| PLTs (×103/μL) | 291 ± 67 | 246 ± 80 | 134 ± 75 |
| MCV (fL) | 46.7 ± 0.6 | 53.6 ± 3.9 | 51.9 ± 9.3 |
| BM count (×107 cells) | 2.70 ± 0.78 | 7.05 ± 1.67 | 4.83 ± 1.14 |
| Myeloblasts in BM (%) | 1.8 ± 1.0 | 34.5 ± 16.0 | 59.6 ± 8.2 |
| Liver weight (mg) | 1668 ± 129 | 2008 ± 482 | 2015 ± 527 |
| Spleen weight (mg) | 98 ± 12 | 605 ± 242 | 531 ± 185 |
| Characteristics . | pMYs.IG/pMYs.IN (n = 3) . | D171N/pMYs.IN (n = 5) . | D171N/BMI1 (n = 10) . |
|---|---|---|---|
| WBCs (/μL) | 18 550 ± 1786 | 129 100 ± 68 089 | 70 838 ± 16 353 |
| Hb (g/dL) | 14.8 ± 0.4 | 7.3 ± 2.5 | 7.7 ± 2.3 |
| PLTs (×103/μL) | 291 ± 67 | 246 ± 80 | 134 ± 75 |
| MCV (fL) | 46.7 ± 0.6 | 53.6 ± 3.9 | 51.9 ± 9.3 |
| BM count (×107 cells) | 2.70 ± 0.78 | 7.05 ± 1.67 | 4.83 ± 1.14 |
| Myeloblasts in BM (%) | 1.8 ± 1.0 | 34.5 ± 16.0 | 59.6 ± 8.2 |
| Liver weight (mg) | 1668 ± 129 | 2008 ± 482 | 2015 ± 527 |
| Spleen weight (mg) | 98 ± 12 | 605 ± 242 | 531 ± 185 |
Averages and standard deviations are shown. BM cells were isolated from both tibias and femurs.
Hb, hemoglobin; MCV, mean corpuscular volume; PLTs, platelets.