Gender, n (%) | |
Female | 20 (45) |
Male | 24 (55) |
Age, median (range), y | 54 (35-72) |
History of celiac disease, n (%) | 25 (57) |
Disease stage at dx (Ann Arbor), n (%) | |
I | 9 (20) |
II | 14 (32) |
IV | 19 (43) |
Data missing | 2 (5) |
B-symptoms at dx, n (%) | 22 (54) |
Initial therapy | |
CHOP | 18 (43) |
CHOP/IVE/MTX | 4 (9)* |
CHOEP | 4 (9) |
ACVBP | 3 (7) |
IVE | 3 (7) |
Other/unknown | 12 (27) |
Antibody included | 2 (5) |
No. of treatment lines before ASCT, n (%) | |
1 | 19 (46) |
2 | 15 (34) |
>2 | 4 (9) |
Data missing | 4 (9) |
Time from dx to ASCT, median (range), mo | 6 (3-32)† |
Disease status at transplant, n (%) | |
CR or PR1 | 31 (70) |
More advanced | 13 (30)‡ |
High-dose regimen, n (%) | |
BEAM | 36 (82) |
TBI | 4 (9) |
Stem cell source PB, n (%) | 44 (100) |
Gender, n (%) | |
Female | 20 (45) |
Male | 24 (55) |
Age, median (range), y | 54 (35-72) |
History of celiac disease, n (%) | 25 (57) |
Disease stage at dx (Ann Arbor), n (%) | |
I | 9 (20) |
II | 14 (32) |
IV | 19 (43) |
Data missing | 2 (5) |
B-symptoms at dx, n (%) | 22 (54) |
Initial therapy | |
CHOP | 18 (43) |
CHOP/IVE/MTX | 4 (9)* |
CHOEP | 4 (9) |
ACVBP | 3 (7) |
IVE | 3 (7) |
Other/unknown | 12 (27) |
Antibody included | 2 (5) |
No. of treatment lines before ASCT, n (%) | |
1 | 19 (46) |
2 | 15 (34) |
>2 | 4 (9) |
Data missing | 4 (9) |
Time from dx to ASCT, median (range), mo | 6 (3-32)† |
Disease status at transplant, n (%) | |
CR or PR1 | 31 (70) |
More advanced | 13 (30)‡ |
High-dose regimen, n (%) | |
BEAM | 36 (82) |
TBI | 4 (9) |
Stem cell source PB, n (%) | 44 (100) |
ACVBP, doxorubicin-cyclophosphamide-vindesine-bleomycin-prednisone; BEAM, carmustine-etoposide-cytosine arabinoside-melphalan; CHOEP, cyclophosphamide-doxorubicin-vincristine-etoposide-prednisone; CHOP, cyclophosphamide-doxorubicin-vincristine-prednisone; CR, complete remission; dx, diagnosis; IVE, ifosfamide-etoposide-epirubicin; MTX, methotrexate; PB, peripheral blood; PR, partial remission; TBI, total body irradiation.
Methotrexate included in initial therapy in 8 patients.
Median time 6 months (3-14) in patients transplanted in the first CR or PR and 12 months (4-32) in patients transplanted with more advanced disease status (P = .0036).
Sensitive relapse in 3 patients, unspecified relapse in 2 patients, CR2 in 3 patients, unspecified CR in 1 patient, and PR >1 in 2 patients.